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LSM1

Official Full Name

LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Overview

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Synonyms

LSM1; LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); U6 snRNA-associated Sm-like protein LSm1; anti-LSM1; Cancer associated Sm like protein; Cancer associated Sm-like; Cancer-associated Sm-like; CASM; Lsm1 protein; LSM1_HUMAN; Small nuclear ribonuclear CaSm; U6 snRNA associated Sm-like protein LSm1; YJL124C; cancer-associated Sm-like protein;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E. coli
E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LSM1-3006H	Recombinant Human LSM1 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae), T7-tagged	E.coli	T7		Inquiry
Human	LSM1-2818H	Recombinant Human LSM1, His-tagged	E.coli	His		Inquiry
Human	LSM1-331H	Recombinant Human LSM1 protein(Met1-Tyr133), His-tagged	E. coli	N-His	Met1-Tyr133	Inquiry
Human	LSM1-4613HCL	Recombinant Human LSM1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	LSM1-6121HF	Recombinant Full Length Human LSM1 Protein, GST-tagged	In Vitro Cell Free System	GST	133 amino acids	Inquiry
Human	LSM1-4618H	Recombinant Human LSM1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	LSM1-618H	Recombinant Human LSM1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	LSM1-4202H	Recombinant Human LSM1 Protein (Met1-Tyr133), C-His tagged	E.coli	C-His	Met1-Tyr133	Inquiry
Mouse	Lsm1-3852M	Recombinant Mouse Lsm1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	LSM1-985Z	Recombinant Zebrafish LSM1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LSM1 Related Articles

LSM1 involved in several pathways and played different roles in them. We selected most pathways LSM1 participated on our site, such as Arginine and proline metabolism, Creatine metabolism, Glycine, serine and threonine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LSM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arginine and proline metabolism	SRM;CNDP1;PRODH2;DAO.2;NOS3;DHDPSL;P4HA1;ABP1;P4HA1B
Creatine metabolism	SLC6A12;CKMT2A;CKM;CKMT2;CKB;SLC6A7;CKBA;CKMT1B;CKMB
Glycine, serine and threonine metabolism	MAOA;DAO1;AGXTB;GCSHA;SRR;GCAT;PIPOX;PGAM1B;PSAT1
Metabolic pathways	ST3GAL6;GCNT1;CEPT1B;OGDHA;ctaG;RDH10A;CERS5;B4GALT7;NDUFC2-KCTD14
Metabolism	NUDT3;CYGB1;DECR1;HELZ2;APOA5;PDP2;GLS2B;GPHN;MED20
Metabolism of amino acids and derivatives	AZIN1A;DBH;SLC6A7;PPM1K;CDO1;SAT1B;CKMT1B;BCKDK;ACMSD
Metabolism of polyamines	SLC6A7;CKBA;SAT1B;PAOX;OAZ1;CKMT2;SLC6A8;LSM1;OAZ2
Urea cycle and metabolism of amino groups	LSM1;CKB;CKM

LSM1 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity, guanidinoacetate N-methyltransferase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LSM1 itself. We selected most functions LSM1 had, and list some proteins which have the same functions with LSM1. You can find most of the proteins on our site.

Function	Related Protein
S-adenosylmethionine-dependent methyltransferase activity	TPMT.1;LSM1;COQ5;ASMT2;METTL7A;C6orf211;PRMT8B;SUV39H1;PRMT7
guanidinoacetate N-methyltransferase activity	LSM1;GAMT
protein homodimerization activity	BST2;MCL1;SH3GLB1;PRDM6;HLCS;ACTN4;CHMP3;MFF;TOX3

LSM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LSM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LSM1.

LSM3; LSM4; CLIC1; NARS; HSP90AA1; PSMB8; PSMB5; LSM6; RRP1B; TMEM214; q81ky6_bacan; q81wx2_bacan; EXOSC8; FAM136A

Godfrey, AC; White, AE; et al. The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. RNA-A PUBLICATION OF THE RNA SOCIETY 15:1661-1672(2009).