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MAP3K13

Official Full Name

mitogen-activated protein kinase kinase kinase 13
Background

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
Synonyms

MAP3K13; mitogen-activated protein kinase kinase kinase 13; leucine zipper bearing kinase; LZK; MEKK13; mixed lineage kinase; leucine zipper-bearing kinase; MLK; MGC133196;

Type:
Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Human
Mouse

Source :
E.coli
HEK293
Mammalian Cell

Tag :
GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MAP3K13-1055HCL	Recombinant Human MAP3K13 cell lysate		N/A	Inquiry
Human	MAP3K13-3713H	Recombinant Human MAP3K13 protein, GST-tagged	E.coli	GST	$319.00 / 25ug
Mouse	MAP3K13-9509M	Recombinant Mouse MAP3K13 Protein	Mammalian Cell	His	Inquiry
Mouse	MAP3K13-5330M-B	Recombinant Mouse MAP3K13 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	MAP3K13-5330M	Recombinant Mouse MAP3K13 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug

Involved Pathway
Protein Function
Interacting Protein
MAP3K13 Related Articles

MAP3K13 involved in several pathways and played different roles in them. We selected most pathways MAP3K13 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	IKBKB;NTRK2B;CACNA1BA;NTF3;MAPK8;HSPA8;PTPRR;MKNK1;CACNA1C

MAP3K13 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K13 itself. We selected most functions MAP3K13 had, and list some proteins which have the same functions with MAP3K13. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	SIK2;HSPA4;CDK4;NADKD1;PRKAA1;MAPK13;ABCA4;ACTR2;SMARCA2
MAP kinase kinase kinase activity	KIAA1804;MAP3K1;ALPK2;RAF1;MAP3K15;MAP3K4;TAOK2;TAOK1;MOS
identical protein binding	NEFL;TRP53;SYNE1;ANXA4;TYSND1;SNX33;DCTPP1;DYNLRB1;SNCAIP
metal ion binding	HEPHL1;CAR15;PPP2CA;MYBPC3;ZUFSP;ZNF565;SP2;NEK2;ACSM2
protein binding	TTYH2;FBXO2;RAB17;HIRA;LC3;PXN;ITGB3BP;NFYC;SMARCAL1
protein homodimerization activity	COQ9;GDNF;CCDC103;GRPEL1;RRAGA;DPY30;TSG101;GPD1A;BOKA
protein kinase binding	MLKL;LAX1;NR4A3;ATF2;SHC3;TNNI3;BAD;PRKAG1;CCNT2B
protein serine/threonine kinase activity	WNK2;ACVR2A;CSNK2A1;RPS6KB2;PRKCBB;CDKL5;SNRKA;PLK4;MAP2K6

MAP3K13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K13.

STAT3; HLA-DRB3; GLO1

Du, X; Li, YM; et al. Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1559-1564(2014).

Mongkhon, JM; Thach, M; et al. Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes. INFLAMMATION RESEARCH 63:691-701(2014).