MAP3K2

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 2

  • Overview

    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.
  • Synonyms

    MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAP3K2 Related Signal Pathway

MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BDNF signaling pathwayGNB2L1;SIRPA;GRIP1;CSNK2A1P;DOK5;MAP3K2;EGR2;FRS2;CSNK2A1
EGFR1 Signaling PathwaySH3BGRL;EEF1A1;ZFP259;KRT17;ABI1B;GRB10;KLF11;RALBA;CRKL
ErbB1 downstream signalingEPS8;ABI1;CHN2;WASF2;NCKAP1;ACTR2;BAIAP2;EGR1;ARF4
Gap junctionPDGFB;GRB2A;ITPR3;CX35B;TUBB2A;TUBA1L2;TUBA1A;PDGFAB;GNAI2
GnRH signaling pathwayCALM2A;CDC42L;PLCB2;GNRHR1;CALM2;MAP3K3;CACNA1SB;MAPK7;PRKACBA
Insulin SignalingGRB14;MAP3K9;CAP1;ARHGAP33;SNAP25A;SGK2;MAP4K1;KIF5B;MAP3K2
MAPK CascadeMAP2;MBPB;MAP3K2;MBP
MAPK signaling pathwayPPP3R1;CACNA1SB;MAPK14B;FGF12A;FGF13B;MAP2K2;MAPK13;PRKACBA;CACNA2D4

MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingEPHA6;PSTK;MAP4K5;UBE2D4;LACE1;TNIKB;RBKS;MYH9A;FYNB
MAP kinase kinase kinase activitySTK4;MAP3K13;MAP3K14;ZAK;MAP3K2;MOS;MAP3K3;MAP3K6;MAP3K4
metal ion bindingPRKAA2;ZFP518A;RPE;ZBTB12.2;DGKE;ZBTB17;CISD2;ZNF100;CYP2AA7
protein bindingXBP1;AMPD2;OTUD7B;CROP;PTPLAD1;MAGEE1;PTPRD;FHIT;BFSP1
protein kinase activityNTRK3A;CCL5;KALRN;EIF2AK3;SRPK1B;EPHB4B;ACVR2AA;BMPR2B;NEK12
protein kinase bindingPRKCZ;LATS1;CD24;SPRY2;FGFR1OP;ARHGEF7;CCNE2;GRB2;SLC12A5
protein serine/threonine kinase activityADCK4;STK38;GM711;PRKCHB;ACVRL1;RPS6KA5;MELK;PHKG2;PLK2

MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

YWHAB; YWHAE; SFN; YWHAG; STUB1; saicar

Research Area

Related articles

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
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