MAP3K2

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MAP3K2

Official Full Name mitogen-activated protein kinase kinase kinase 2
Background The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.
Synonyms MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K2-1258H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged Insect Cell GST
    Human MAP3K2-30191TH Recombinant Human MAP3K2 N/A
    Human MAP3K2-351H Recombinant Human MAP3K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP3K2-4506HCL Recombinant Human MAP3K2 293 Cell Lysate HEK293 N/A
    Human MAP3K2-897H Recombinant Human MAP3K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Map3k2-3929M Recombinant Mouse Map3k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BDNF signaling pathway FRS3; SYN1; EIF4E; DOK5; EGR1; CFL1; LINGO1; GNB2L1; EIF4EBP1; CSNK2A1P
    EGFR1 Signaling Pathway KRT8; RALBA; REPS2; WNK1; MAP3K2; CEBPB; CEBPA; REPS1; SH2D3C; EPPK1
    ErbB1 downstream signaling CHN2; ABI1; MAP3K2; NCKAP1; WASF2; ACTR2; ACTR3; BAIAP2; ARF4; EGR1
    Gap junction DRD2A; TUBA4L; Pdgfa&Pdgfb; DRD1B; HRAS; SOS1; TUBA8L2; PRKCBA; TUBB2B; HRASB
    GnRH signaling pathway CALML5; PRKACAB; MMP14; CAMK2B; CDC42L; GNRH3; FSHB; GNRHR2; CAMK2D1; CAMK2G1
    Insulin Signaling GRB14; ARHGAP33; STXBP1A; REG1A; GRB10; MAP3K9; RRAD; KIF5B; FLOT1; MAP3K10
    MAPK Cascade MAP3K2; MBP; MBPB; MAP2
    MAPK signaling pathway MAPK8B; PRKACB; PPP3CCB; CACNB2A; FGF9; C11orf52; PPM1BB; GADD45BA; RELB; PRKACAA

    MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding HCK; UBE2B; PRPF4BB; ADCY7; TGFBR2; TNIK; CAMK2D2; LACE1; FIGNL2; KIFC2
    MAP kinase kinase kinase activity MAP3K15; MAP3K5; TAOK3; ZAK; MAP3K4; MAP3K1; STK3; ALPK2; KIAA1804; MAP3K8
    metal ion binding ZNF697; SALL2; KLF2; CYP8B1; KARS; GLIS3; LIG1; ZFP750; NIM1; ZNFL1
    protein binding WDR61; NDUFA9; F11R; MPPE1; C10orf96; SPTSSA; TOMM34; SUGT1; IFT20; OIP5
    protein kinase activity PRKDC; MYO3A; PLK1; MAP2K4B; LMTK3; NAT1; RIPK1; cka1; FYNA; BMPR1BA
    protein kinase binding IKBKB; MAP2K6; SPRED1; STAP1; NSF; NME2; RAD9A; ERRFI1; FOXM1; TTN
    protein serine/threonine kinase activity TSSK5; BCKDK; CAMK2D; OBSCN; BMPR1B; MAPK12A; STK38L; HUNK; TLK1B; STK32C

    MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

    YWHAB; YWHAE; SFN; YWHAG; STUB1; saicar

    Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).

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