|Official Full Name||mitogen-activated protein kinase kinase kinase 2|
|Background||The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.|
|Synonyms||MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|BDNF signaling pathway||BCL2L11; CNR1; FRS3; EIF2S1; CFL1; CSNK2A1P; MAP3K2; DOK5; EIF4EBP1; SIRPA|
|EGFR1 Signaling Pathway||RBB4L; KRT17; TNK2; RGS16; MTA2; ERRFI1; SH2D3C; KRT8; RALBP1; ZFP259|
|ErbB1 downstream signaling||CHN2; MAP3K2; BAIAP2; EGR1; WASF2; ACTR3; ABI1; ARF4; NCKAP1; EPS8|
|Gap junction||GNA11B; HTR2B; GJA1; ITPR3; RAF1B; GRB2; TUBA8; TUBA8L3; PRKG1A; PRKACAA|
|GnRH signaling pathway||CDC42; GNRHR2; MAP2K2B; PLCB3; GNA11A; CALM3A; MMP14; MAP3K3; CAMK2B1; MAP2K4B|
|Insulin Signaling||CAP1; RRAD; STXBP4; FLOT1; MAP3K2; MAPK4; MAPK6; MYO1C; KIF5B; GRB14|
|MAPK Cascade||MAP3K2; MAP2; MBP; MBPB|
|MAPK signaling pathway||SOS1; CACNG6A; CACNB2; FGF18A; MINK1; JIP1; MAP3K11; FGF6A; MAPKAPK2; MAP2K5|
MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.
|ATP binding||MAP4K1; OXSR1; KIF19; ZAP70; CAMKK1B; HUNK; PIK3C2G; UBE1Y1; PIP4K2C; LONP1|
|MAP kinase kinase kinase activity||MAP3K1; TAOK2; YSK4; TAOK3; ALPK2; MAP3K4; ZAK; TAOK1; MAP3K8; MAP3K13|
|metal ion binding||CA15C; ZBED5; KLF6A; ELAC1; PDE7B; ATP2B1A; NRP1; RNF11B; PDE4D; NT5C2|
|protein binding||SH3BP1; CCS; BCOR; MFN1; CKS1B; NUF2; CLINT1; NAT10; TRAF4; SOSTDC1B|
|protein kinase activity||PRKAG1; HIPK3B; AKT3; CSNK1DB; MAPK8B; MAK; SRPK1A; ACVR2AA; RAF1A; CDK9|
|protein kinase binding||PTPRR; VRK1; TMEM173; APC; PTPRJ; CAV1; CDK5RAP2; CDK5RAP3; RICTOR; AKAP5|
|protein serine/threonine kinase activity||ACVR1L; RIOK3; VRK3; MARK4; RIPK1; MAPK8; CAMK2D2; RPS6KC1; SLC14A2; SIK3|
MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.
YWHAB; YWHAE; SFN; YWHAG; STUB1; saicar