MAP3K2

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 2

  • Overview

    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.

  • Synonyms

    MAP3K2;mitogen-activated protein kinase kinase kinase 2;MEKK2;MAP/ERK kinase kinase 2;MEKK2B;M3K2_HUMAN;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2;Mitogen activated protein kinase kinase kinase 2;OTTHUMP00000203817;OTTHUMP00000203818

Recombinant Proteins

  • Human
  • Mouse
  • Insect Cells
  • Sf9 Cells
  • HEK293
  • Mammalian Cells
  • GST
  • Non
  • Avi
  • Fc
  • His
  • Flag
  • DDK
  • Myc

    Involved Pathway

    MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway,EGFR1 Signaling Pathway,ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB1 downstream signaling EGR1,BAIAP2,WASF2,ACTR2,NCKAP1,ABI1,EPS8,ACTR3,CHN2,ARF4
    MAPK Cascade MBP,MAP2,MBPB
    BDNF signaling pathway FRS3,CSNK2A1,CSNK2A1P,CFL1,YBX1,IGF2BP1,EIF2S1,DPYSL2,CNR1,FRS2
    GnRH signaling pathway SOS1,PRKACBB,GNA11,MAPK7,PRKCB,HRASA,LHBETA1,CDC42L2,MAPK9,GNA15.4
    Insulin Signaling GRB10,STXBP1A,MAP4K1,MAP4K5,SGK2,INPP4AA,MAP3K10,STXBP4,RHOJ,STXBP3A
    MAPK signaling pathway MAP3K1,NGF,CACNG7,MAPK7,FLNC,MKNK2A,FGFR2,NF1,PRKACG,PLA2G4C
    Gap junction HRASA,PRKACBB,TUBA3E,PDGFC,PRKCG,TUBB2,ADRB3B,SRC,TUBB6,PLCB4
    EGFR1 Signaling Pathway APPL2,GRB10,PITPNAA,CEBPA,USP6NL,PITPNA,REPS2,RGS16,KLF11,TNIP1

    Protein Function

    MAP3K2 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SPS2,STK30,WEE2,RTCA,BRIP1,BCKDK,ITK,CBWD2,CDK20,ATP1A3A
    protein kinase activity GUCY2F,GRK7B,SBK1,BMPR2B,RNASEL,GM7168,CSNK1DB,EPHB4B,LIMK1,PPP1R9B
    metal ion binding CMTM2A,RFNG,ZFP2,ZNF643,GLIS3,MAT1A,PVALB2,ATP2B1A,NT5DC1,SUMF2
    protein serine/threonine kinase activity RAF1A,TRIO,AKT3,STK39,DCKL1B,TGFBR1B,STK3,TTBK1,RPS6KC1,MTOR
    protein kinase binding NPR1,MAP2K6,PLK1,CCNT2B,EPHA1,CALM1,STK11IP,Cd24a,SYN1,CCNL1
    MAP kinase kinase kinase activity YSK4,STK3,ALPK2,TAOK1,MAP3K5,TAOK2,RAF1,MAP3K4,TAOK3,MAP3K1
    protein binding ZFPM2A,MAF,NPY2R,Clec4n,STAU1,BLMH,ABCB1,NXF1,KCTD5,SMC3

    Interacting Protein

    MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

    YWHAB;YWHAE;SFN;YWHAG;STUB1;saicar

    MAP3K2 Related Signal Pathway

    Resources

    Research Area

    MAP3K
    Post-translational Modification of NFkB/IkB

    References

    • Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    • Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All MAP3K2 Products

    Required fields are marked with *

    My Review for All MAP3K2 Products

    Required fields are marked with *