MAP3K2

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 2

  • Overview

    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.

  • Synonyms

    MAP3K2;mitogen-activated protein kinase kinase kinase 2;MEKK2;MAP/ERK kinase kinase 2;MEKK2B;M3K2_HUMAN;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2;Mitogen activated protein kinase kinase kinase 2;OTTHUMP00000203817;OTTHUMP00000203818

Recombinant Proteins

  • Human
  • Mouse
  • Insect Cells
  • Sf9 Cells
  • HEK293
  • Mammalian Cells
  • GST
  • Non
  • Avi
  • Fc
  • His
  • Flag
  • DDK
  • Myc

    Involved Pathway

    MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway,EGFR1 Signaling Pathway,ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gap junction MAP2K5,ADCY2B,TUBB,PRKCA,PRKCBA,PRKG1,GNA11,HRASA,PRKACAB,PRKCG
    MAPK Cascade MBP,MAP2,MBPB
    ErbB1 downstream signaling EPS8,ARF4,CHN2,ABI1,NCKAP1,WASF2,ACTR3,EGR1,BAIAP2,ACTR2
    GnRH signaling pathway LHBETA1,MAP2K6,GRB2A,CALM2,PLA2G4C,SOS1,GNRH2,ITPR3,CALM1,GNA11A
    Insulin Signaling RHOJ,SNAP25A,MAP4K5,ARHGAP33,MYO1C,STXBP3,FLOT1,KIF5B,MAP4K1,STXBP1A
    MAPK signaling pathway CD14,PPP3CCA,AKT2,PPM1AB,FGF13,FGF12A,MAP2K1,FGF9,MAPK7,MAPKAPK2A
    EGFR1 Signaling Pathway GRB10,ERRFI1,DNM1,APPL2,PITPNA,AP2A1,RGS16,REPS2,EPS8,KLF11
    BDNF signaling pathway GRIP1,GNB2L1,KCNN2,SYN1,FRS2,YBX1,CDKL5,CSNK2A1P,EIF4EBP1,JAK2

    Protein Function

    MAP3K2 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MARCH2,NEBL,GMIP,SLX4IP,MPP2,TSKS,EIF3H,HMGB3,MAGEA9,SNX12
    metal ion binding PCK2,NR1H5,KAT8,OTUD7A,ITPK1A,ITGA8,ETFDH,RBM26,CYP2AA9,THAP7
    ATP binding DDX39AA,MAP3K6,KIF7,POMK,FGR,FIGNL2,OASL2,DCLK1,PFKFB2,Ckmm
    protein kinase binding DBF4B,ARHGEF7,NME2,ATF2,PRKAG1,BCL10,KIF14,PTPRR,FBXO5,HDAC7A
    protein serine/threonine kinase activity SLKA,TRIOA,DMPK,MAP4K6,SLC14A2,SLK,NIM1,NEK8,STK4,cka1
    MAP kinase kinase kinase activity BRAF,TAOK1,MAP3K15,MAP3K12,ALPK2,MAP3K8,MAP3K3,RAF1,STK3,YSK4
    protein kinase activity TBCK,EEF2K,PAK2,INSRA,ARAF,CDK8,CAMK1DB,CDK14,DCLK2,CDK7

    Interacting Protein

    MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

    YWHAB;YWHAE;SFN;YWHAG;STUB1;saicar

    MAP3K2 Related Signal Pathway

    Resources

    Research Area

    MAP3K
    Post-translational Modification of NFkB/IkB

    References

    • Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    • Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).

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