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MAP3K2

Official Full Name

mitogen-activated protein kinase kinase kinase 2
Overview

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.
Synonyms

MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Mouse

Source

HEK293
HEK293T
Insect Cell
Mammalian cells
Sf21
Sf9 Insect Cell

Tag

Flag
GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP3K2-108HFL	Active Recombinant Full Length Human MAP3K2 Protein, N-His-tagged	Sf21	His	Full Length	Inquiry
Human	MAP3K2-351H	Recombinant Human MAP3K2, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	MAP3K2-30191TH	Recombinant Human MAP3K2		N/A		Inquiry
Human	MAP3K2-1258H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged	Insect Cell	GST		Inquiry
Human	MAP3K2-4506HCL	Recombinant Human MAP3K2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MAP3K2-1574HFL	Recombinant Full Length Human MAP3K2 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	MAP3K2-1358H	Recombinant Human MAP3K2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	MAP3K2-897H	Recombinant Human MAP3K2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MAP3K2-1358H-B	Recombinant Human MAP3K2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Map3k2-3929M	Recombinant Mouse Map3k2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
MAP3K2 Related Signal Pathway

MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
BDNF signaling pathway	GNB2L1;SIRPA;GRIP1;CSNK2A1P;DOK5;MAP3K2;EGR2;FRS2;CSNK2A1
EGFR1 Signaling Pathway	SH3BGRL;EEF1A1;ZFP259;KRT17;ABI1B;GRB10;KLF11;RALBA;CRKL
ErbB1 downstream signaling	EPS8;ABI1;CHN2;WASF2;NCKAP1;ACTR2;BAIAP2;EGR1;ARF4
Gap junction	PDGFB;GRB2A;ITPR3;CX35B;TUBB2A;TUBA1L2;TUBA1A;PDGFAB;GNAI2
GnRH signaling pathway	CALM2A;CDC42L;PLCB2;GNRHR1;CALM2;MAP3K3;CACNA1SB;MAPK7;PRKACBA
Insulin Signaling	GRB14;MAP3K9;CAP1;ARHGAP33;SNAP25A;SGK2;MAP4K1;KIF5B;MAP3K2
MAPK Cascade	MAP2;MBPB;MAP3K2;MBP
MAPK signaling pathway	PPP3R1;CACNA1SB;MAPK14B;FGF12A;FGF13B;MAP2K2;MAPK13;PRKACBA;CACNA2D4

MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	EPHA6;PSTK;MAP4K5;UBE2D4;LACE1;TNIKB;RBKS;MYH9A;FYNB
MAP kinase kinase kinase activity	STK4;MAP3K13;MAP3K14;ZAK;MAP3K2;MOS;MAP3K3;MAP3K6;MAP3K4
metal ion binding	PRKAA2;ZFP518A;RPE;ZBTB12.2;DGKE;ZBTB17;CISD2;ZNF100;CYP2AA7
protein binding	XBP1;AMPD2;OTUD7B;CROP;PTPLAD1;MAGEE1;PTPRD;FHIT;BFSP1
protein kinase activity	NTRK3A;CCL5;KALRN;EIF2AK3;SRPK1B;EPHB4B;ACVR2AA;BMPR2B;NEK12
protein kinase binding	PRKCZ;LATS1;CD24;SPRY2;FGFR1OP;ARHGEF7;CCNE2;GRB2;SLC12A5
protein serine/threonine kinase activity	ADCK4;STK38;GM711;PRKCHB;ACVRL1;RPS6KA5;MELK;PHKG2;PLK2

MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

YWHAB; YWHAE; SFN; YWHAG; STUB1; saicar

Research Area

Post-translational Modification of NFkB/IkB

MAP3K

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).

Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).