MAP3K2

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 2

  • Overview

    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.
  • Synonyms

    MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K2-30191TH Recombinant Human MAP3K2 N/A
Human MAP3K2-351H Recombinant Human MAP3K2, GST-tagged, Active Sf9 Insect Cell GST
Human MAP3K2-1258H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged Insect Cell GST
Human MAP3K2-4506HCL Recombinant Human MAP3K2 293 Cell Lysate HEK293 N/A
Human MAP3K2-897H Recombinant Human MAP3K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP3K2-1358H Recombinant Human MAP3K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP3K2-1574HFL Recombinant Full Length Human MAP3K2 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP3K2-1358H-B Recombinant Human MAP3K2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Map3k2-3929M Recombinant Mouse Map3k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP3K2 Related Articles
  • MAP3K2 Related Research Area
  • MAP3K2 Related Signal Pathway

MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BDNF signaling pathwayCDK5;SIRPA;MAP3K2;EIF2S1;LINGO1;CFL1;EIF4EBP1;GRIP1;EGR1
EGFR1 Signaling PathwayTNK2;PITPNA;GRB7;KRT7;ERRFI1;RALBA;KLF11;STXBP1A;SPRY2
ErbB1 downstream signalingBAIAP2;ACTR2;ABI1;EPS8;MAP3K2;ARF4;WASF2;EGR1;NCKAP1
Gap junctionGRB2;SOS1;RAF1;TUBA1C;LPAR1;CX35B;MAP2K2B;RAF1A;PRKCG
GnRH signaling pathwayPRKACB;CAMK2B;MAP2K1;MAP2K7;MAPK8A;GNRHR;CAMK2G;PRKACBB;MAP3K3
Insulin SignalingCAP1;MAP3K9;STXBP4;SNAP25A;RHOJ;FLOT1;REG1A;MAPK6;SGK2
MAPK CascadeMAP3K2;MBPB;MAP2;MBP
MAPK signaling pathwayCD14;MAP4K3;MAPK7;MAPK14B;FGF18A;FGF2;AKT2;FGF5;NGF

MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYH4;DDX6;DYNC1H1;BMPR2;UBE2E1;KDR;NLRP3;NMRK2;APAF1
MAP kinase kinase kinase activityMAP3K5;ZAK;MAP3K3;YSK4;MAP3K12;EGFR;MAP3K8;TAOK2;MAP3K2
metal ion bindingZFP526;KITA;SMYD2B;HCCS;VEZF1B;ZBTB22;ZFP423;PPARDB;ZC3H18
protein bindingKHDRBS3;MARK4;MOB4;ARPM1;ZBTB5;FBXO4;VPS18;RAB3C;MCC
protein kinase activitySBK1;PKDCC;RIPK4;PKN2;RPS6KA3B;HIPK3A;TRIM24;MAP3K4;CDC42BPB
protein kinase bindingCCNK;PIFO;MSN;HNRNPA0;ACVRL1;POLA1;PEBP1;TRIB3;DLG1L
protein serine/threonine kinase activitySTK16;GM7168;PIK3R4;MAPK4;ROCK2A;C9orf96;RIPK2;STK25;NEK10

MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

YWHAB; YWHAE; SFN; YWHAG; STUB1; saicar

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
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