MAP3K2 Protein


Home / Products / MAP3K2


Official Full Name mitogen-activated protein kinase kinase kinase 2
Background The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.
Synonyms MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B; M3K2_HUMAN; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mitogen activated protein kinase kinase kinase 2; OTTHUMP00000203817; OTTHUMP00000203818
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K2-1258H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged Insect Cell GST
    Human MAP3K2-30191TH Recombinant Human MAP3K2 N/A
    Human MAP3K2-351H Recombinant Human MAP3K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP3K2-4506HCL Recombinant Human MAP3K2 293 Cell Lysate HEK293 N/A
    Human MAP3K2-897H Recombinant Human MAP3K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Map3k2-3929M Recombinant Mouse Map3k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BDNF signaling pathway BCL2L11; CNR1; FRS3; EIF2S1; CFL1; CSNK2A1P; MAP3K2; DOK5; EIF4EBP1; SIRPA
    EGFR1 Signaling Pathway RBB4L; KRT17; TNK2; RGS16; MTA2; ERRFI1; SH2D3C; KRT8; RALBP1; ZFP259
    ErbB1 downstream signaling CHN2; MAP3K2; BAIAP2; EGR1; WASF2; ACTR3; ABI1; ARF4; NCKAP1; EPS8
    Gap junction GNA11B; HTR2B; GJA1; ITPR3; RAF1B; GRB2; TUBA8; TUBA8L3; PRKG1A; PRKACAA
    GnRH signaling pathway CDC42; GNRHR2; MAP2K2B; PLCB3; GNA11A; CALM3A; MMP14; MAP3K3; CAMK2B1; MAP2K4B
    Insulin Signaling CAP1; RRAD; STXBP4; FLOT1; MAP3K2; MAPK4; MAPK6; MYO1C; KIF5B; GRB14
    MAPK Cascade MAP3K2; MAP2; MBP; MBPB
    MAPK signaling pathway SOS1; CACNG6A; CACNB2; FGF18A; MINK1; JIP1; MAP3K11; FGF6A; MAPKAPK2; MAP2K5

    MAP3K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP4K1; OXSR1; KIF19; ZAP70; CAMKK1B; HUNK; PIK3C2G; UBE1Y1; PIP4K2C; LONP1
    MAP kinase kinase kinase activity MAP3K1; TAOK2; YSK4; TAOK3; ALPK2; MAP3K4; ZAK; TAOK1; MAP3K8; MAP3K13
    metal ion binding CA15C; ZBED5; KLF6A; ELAC1; PDE7B; ATP2B1A; NRP1; RNF11B; PDE4D; NT5C2
    protein binding SH3BP1; CCS; BCOR; MFN1; CKS1B; NUF2; CLINT1; NAT10; TRAF4; SOSTDC1B
    protein kinase activity PRKAG1; HIPK3B; AKT3; CSNK1DB; MAPK8B; MAK; SRPK1A; ACVR2AA; RAF1A; CDK9
    protein kinase binding PTPRR; VRK1; TMEM173; APC; PTPRJ; CAV1; CDK5RAP2; CDK5RAP3; RICTOR; AKAP5
    protein serine/threonine kinase activity ACVR1L; RIOK3; VRK3; MARK4; RIPK1; MAPK8; CAMK2D2; RPS6KC1; SLC14A2; SIK3

    MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.


    Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).

    Q&As (0)

    Ask a Question for All BRAF Products

    Required fields are marked with *

    • Verification Code

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2023 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy