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MAP4K4

Official Full Name

mitogen-activated protein kinase kinase kinase kinase 4
Overview

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; hepatocyte progenitor kinase like/germinal center kinase like kinase; HGK; HPK/GCK like kinase; NIK; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; Ste20 group protein kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; MEKKK4; FLJ10410; FLJ20373; FLJ90111; KIAA0687;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP4K4-27603TH	Recombinant Human MAP4K4	Insect Cell	Non	328 amino acids	Inquiry
Human	MAP4K4-1042H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	MAP4K4-4500HCL	Recombinant Human MAP4K4 293 Cell Lysate	HEK293	Non		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MAP4K4 Related Signal Pathway

MAP4K4 involved in several pathways and played different roles in them. We selected most pathways MAP4K4 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	NLK1;FGFR2;GADD45BB;HSPA1L;PLA2G4C;MAP4K4;RPS6KA1;MAP3K13;TAOK2

MAP4K4 has several biochemical functions, for example, ATP binding, NOT MAP kinase kinase kinase kinase activity, creatine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K4 itself. We selected most functions MAP4K4 had, and list some proteins which have the same functions with MAP4K4. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TBCK;SMC3;ABCC10;FIGNL1;ACTR3B;CDKL3;ABCA13;MAPK10;DDX54
NOT MAP kinase kinase kinase kinase activity	TNIK;MINK1;MAP4K4;NRK;TNIKB;TNIKA
creatine kinase activity	CKMT1A;MAP4K4;CKMT1;CKBB;CKB;CKM;CKMT2;Ckmm;CKMT1B
protein binding	UBE4A;EGF;AP4M1;TRAPPC3;CHRNA5;KPNA6;APLP2;SF3B3;CTGF
protein serine/threonine kinase activity	EIF2AK3;SRPK2;CAMK2D1;PRKG1A;RIPK4;STK30;BCR;ADCK2;ZNF143B

MAP4K4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K4.

GBP3; abl-tide; HSP90AB1; PPARG; MDM2; MINK1; ZRANB1; SLC9A1; PPP1CC; PPP1CA; PRKCE; KIF5A; HIST2H2BE; KIF26B; q81xy5_bacan; thiC; NME7