Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4, GST-tagged

Cat.No. : MAP4K4-1042H
Product Overview : Recombinant human MAP4K4 (1-328) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : MAP4K4-1042H
Description : MAP4K4 is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. MAP4K4 has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by MAP4K4 can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-α signaling. MAP4K4-dependent signaling inhibits PPARγ-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport.
Applications : Kinase Assay; Western Blot
Molecular Weight : 64 kDa
Expression System : Sf9 insect cells using baculovirus.
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Specific Activity: : 54 nmol/min/mg
Purity : > 95 %
Concentration : 0.1 ug/ul
Sequences : 1-328
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Ceramide signaling pathway; Direct p53 effectors; EPHB forward signaling; Insulin Signaling; MAPK signaling pathway; TNF receptor signaling pathway
Gene Name : MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens ]
Official Symbol : MAP4K4
Synonyms : MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; HGK; NIK; FLH21957; FLJ10410; FLJ20373; FLJ90111; KIAA0687; MEKKK 4; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; EC=; OTTHUMP00000207902; OTTHUMP00000207903; OTTHUMP00000207971; OTTHUMP00000207972; OTTHUMP00- 000207973; OTTHUMP00000207974
Gene ID : 9448
mRNA Refseq : NM_004834
Protein Refseq : NP_004825
MIM : 604666
UniProt ID : O95819
Chromosome Location : 2q11.2-q12
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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