Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4, GST-tagged

Cat.No. : MAP4K4-1042H
Product Overview : Recombinant human MAP4K4 (1-328) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : MAP4K4-1042H
Description : MAP4K4 is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. MAP4K4 has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by MAP4K4 can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-α signaling. MAP4K4-dependent signaling inhibits PPARγ-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport.
Applications : Kinase Assay; Western Blot
Molecular Weight : 64 kDa
Expression System : Sf9 insect cells using baculovirus.
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Specific Activity: : 54 nmol/min/mg
Purity : > 95 %
Concentration : 0.1 ug/ul
Sequences : 1-328
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Ceramide signaling pathway; Direct p53 effectors; EPHB forward signaling; Insulin Signaling; MAPK signaling pathway; TNF receptor signaling pathway
Gene Name : MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens ]
Official Symbol : MAP4K4
Synonyms : MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; HGK; NIK; FLH21957; FLJ10410; FLJ20373; FLJ90111; KIAA0687; MEKKK 4; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; EC=2.7.11.1; OTTHUMP00000207902; OTTHUMP00000207903; OTTHUMP00000207971; OTTHUMP00000207972; OTTHUMP00- 000207973; OTTHUMP00000207974
Gene ID : 9448
mRNA Refseq : NM_004834
Protein Refseq : NP_004825
MIM : 604666
UniProt ID : O95819
Chromosome Location : 2q11.2-q12
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity

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