Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4, GST-tagged
| Cat.No. : | MAP4K4-1042H |
| Product Overview : | Recombinant human MAP4K4 (1-328) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
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| Cat. No. : | MAP4K4-1042H |
| Description : | MAP4K4 is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. MAP4K4 has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by MAP4K4 can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-α signaling. MAP4K4-dependent signaling inhibits PPARγ-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport. |
| Applications : | Kinase Assay; Western Blot |
| Molecular Weight : | 64 kDa |
| Expression System : | Sf9 insect cells using baculovirus. |
| Species : | Human |
| Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Specific Activity: : | 54 nmol/min/mg |
| Purity : | > 95 % |
| Concentration : | 0.1 ug/ul |
| Sequences : | 1-328 |
| Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : | Ceramide signaling pathway; Direct p53 effectors; EPHB forward signaling; Insulin Signaling; MAPK signaling pathway; TNF receptor signaling pathway |
| Gene Name : | MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens ] |
| Official Symbol : | MAP4K4 |
| Synonyms : | MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; HGK; NIK; FLH21957; FLJ10410; FLJ20373; FLJ90111; KIAA0687; MEKKK 4; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; EC=2.7.11.1; OTTHUMP00000207902; OTTHUMP00000207903; OTTHUMP00000207971; OTTHUMP00000207972; OTTHUMP00- 000207973; OTTHUMP00000207974 |
| Gene ID : | 9448 |
| mRNA Refseq : | NM_004834 |
| Protein Refseq : | NP_004825 |
| MIM : | 604666 |
| UniProt ID : | O95819 |
| Chromosome Location : | 2q11.2-q12 |
| Function : | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity |
Products Types
| ◆ Recombinant Protein | ||
| MAP4K4-27603TH | Recombinant Human MAP4K4 | +Inquiry |
| ◆ Lysates | ||
| MAP4K4-4500HCL | Recombinant Human MAP4K4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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