Recombinant Human MAP4K4

Cat.No. : MAP4K4-27603TH
Product Overview : Recombinant fragment corresponding to amino acids 1-328 of Human MAP4K4 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, MWt 64kDa.
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Description : The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein length : 328 amino acids
Molecular Weight : 64.000kDa inclusive of tags
Source : Baculovirus
Biological activity : The specific activity of MAP4K4-27603TH was determined to be 54 nmol/min/mg.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens ]
Official Symbol : MAP4K4
Synonyms : MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; hepatocyte progenitor kinase like/germinal center kinase like kinase; HGK; HPK/GCK like kinase; NIK;
Gene ID : 9448
mRNA Refseq : NM_001242559
Protein Refseq : NP_001229488
MIM : 604666
Uniprot ID : O95819
Chromosome Location : 2q11.2-q12
Pathway : Ceramide signaling pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; EPHB forward signaling, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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