MAPRE1
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Official Full Name
microtubule-associated protein, RP/EB family, member 1 -
Overview
End binding protein 1 and may play a part in regulation of microtubule dynamics in the mammalian cells. EB1 could also play a role in the regulation of microtubule assembly and stability. EB1 is essential for proper cilia assembly in fibroblasts. EB1 has been shown to excite spontaneous nucleation and microtubule growth. APC gene mutation and the loss of negatively regulating WNT signaling is thought to play a role in the proliferation changes of cancer. The loss of association with EB1 could contribute to the development of certain cancers. -
Synonyms
MAPRE1;microtubule-associated protein, RP/EB family, member 1;microtubule-associated protein RP/EB family member 1;adenomatous polyposis coli binding protein EB1;EB1;end-binding protein 1;APC-binding protein EB1;adenomatous polyposis coli-binding protein EB1;MGC117374;MGC129946
Recombinant Proteins
- Chicken
- Rhesus macaque
- Human
- Rat
- Mouse
- Mammalian Cells
- E.coli
- Sf9 Cells
- HEK293
- His
- Flag
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
MAPRE1 involved in several pathways and played different roles in them. We selected most pathways MAPRE1 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPRE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G2/M Transition | DYNC1H1,TCTN2,TUBGCP5,CEP164,TSGA14,ODF2B,DCTN1A,CEP152,OFD1,DCTN3 |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | PCM1,CLASP1A,CEP135,DCTN1A,CP110,SDCCAG8,ODF2B,CEP164,CEP76,CCP110 |
| Centrosome maturation | CLASP1,CKAP5,NUMA1,NEDD1,DCTN3,TUBB4A,TUBGCP3,NINL,CEP290,TUBB4B |
| Cell Cycle, Mitotic | ERCC6L,ENSAA,PLK4,CDK6,NDEL1B,TUBGCP2,AHCTF1,E2F3,BORA,CENPN |
| Cell cycle | PDS5B,YWHAG,RAD9A,ORC4L,LMNB1,CENPE,SPO11,TINF2,SPC25,CCND2 |
| Assembly of the primary cilium | TUBB4A,IFT46,KIFAP3,WDR35,MARK4,PKD1,CCDC123,CCT3,KIF3C,TCP1 |
| Anchoring of the basal body to the plasma membrane | CSNK1E,B9D1,FGFR1OP,NINL,HAUS2,SDCCAG8,AKAP9,PCM1,CEP63,TMEM216 |
| Loss of Nlp from mitotic centrosomes | PLK4,ODF2B,CKAP5,NINL,MAPRE1A,CEP135,CEP70,DCTN1A,TSGA14,CEP63 |
Protein Function
MAPRE1 has several biochemical functions, for example, microtubule plus-end binding,poly(A) RNA binding,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPRE1 itself. We selected most functions MAPRE1 had, and list some proteins which have the same functions with MAPRE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | RAD51,NPAT,TJP2,MED12,XRCC5,ID1,CEP120,TNNI3K,PQBP1,LCK |
| poly(A) RNA binding | SREK1,DHX16,FASN,RBFOX2,RPS2,RRP36,DNM1,PTPN1,UCHL5,RPL37A |
| protein binding | SPTBN1,CLIC2,FZD3,GYG1,HSPA8,FLT4,PGAP2,OSR2,SUGP1,IRAK1BP1 |
| microtubule plus-end binding | STIM1,APC,KIF18A,CLASP1A,CLASP1,CLIP2,CLIP1,KIF2C,DST |
Interacting Protein
MAPRE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPRE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPRE1.
APC;KIF2C;DST;TERF1;DSP
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