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MDH1

  • Official Full Name

    malate dehydrogenase 1, NAD (soluble)

  • Overview

    Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms

    MDH1; malate dehydrogenase 1, NAD (soluble); malate dehydrogenase, cytoplasmic; Cytosolic malate dehydrogenase; MDHA; MDHs; Soluble malate dehydrogenase; MOR2; MDH-s; MGC:1375;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Chicken
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MDH1-29754TH Recombinant Human MDH1, His-tagged E.coli His 334 amino acids
Human MDH1-2755H Recombinant Human MDH1, His-tagged E.coli His
Human MDH1-4409HCL Recombinant Human MDH1 293 Cell Lysate HEK293 N/A
Human MDH1-1384H Recombinant Human MDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MDH1-6102HF Recombinant Full Length Human MDH1 Protein, GST-tagged In Vitro Cell Free System GST 334 amino acids
Human MDH1-1546H Recombinant Human MDH1 protein, His & GST-tagged E.coli His/GST Ser2~Ala334 (Accession # P40925)
Human MDH1-4502H Recombinant Human MDH1 Protein, GST-tagged Wheat Germ GST
Human MDH1-1384H-B Recombinant Human MDH1 Protein Pre-coupled Magnetic Beads HEK293
Human MDH1-301623H Recombinant Human MDH1 protein, GST-tagged E.coli GST Met1-Ala334
Human MDH1-4522H Recombinant Human MDH1 Protein (Ser2-Ala334), C-His tagged E.coli C-His Ser2-Ala334
Human MDH1-1976HFL Recombinant Full Length Human MDH1 Protein, C-Flag-tagged Mammalian cells Flag
Human MDH1-4524H Recombinant Human MDH1 Protein (Ser2-Ala334), N-GST tagged E.coli N-GST Ser2-Ala334
Mouse MDH1-9662M Recombinant Mouse MDH1 Protein Mammalian Cell His
Mouse Mdh1-4002M Recombinant Mouse Mdh1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MDH1-5430M-B Recombinant Mouse MDH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse MDH1-5430M Recombinant Mouse MDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MDH1-3628R Recombinant Rat MDH1 Protein Mammalian Cell His
Rat Mdh1-2528R Recombinant Rat Mdh1 protein, His-tagged E.coli His Met4-Ala334
Rat MDH1-3284R-B Recombinant Rat MDH1 Protein Pre-coupled Magnetic Beads HEK293
Rat MDH1-3284R Recombinant Rat MDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mdh1-1770R Recombinant Rat Mdh1 Protein, His&GST-tagged E.coli N-His&GST Ser2-Ala334
Chicken MDH1-1374C Recombinant Chicken Malate Dehydrogenase 1, NAD (Soluble) Chicken N/A
Chicken MDH1-1537C Recombinant Chicken MDH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MDH1 involved in several pathways and played different roles in them. We selected most pathways MDH1 participated on our site, such as Citrate cycle (TCA cycle), Cysteine and methionine metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)SDHD;CS;ACO2;PC;SDHA;DLST;DLD;ACLYA;PDHA1
Cysteine and methionine metabolismCTH;LDHAL6A;MRI1;CDO1;CBSA;IL4I1;DNMT3AB;GOT1;GOT2A
Pyruvate metabolismPDHA1;ACSS1;PDPR;GRHPRA;LDHC;PCXB;ALDH3A2A;ACAT1;ackA
Glyoxylate and dicarboxylate metabolismMDH1;AMT;GLULC;MUT;HYI;MCEE;PCCA;GLYCTK;SHMT2
Metabolic pathwaysEXTL1;PIP5KL1;DOLK;FUT2;ATP6V1BA;DLDH;SAT2B;CNDP2;GCNT1
Carbon metabolismFBP1;HK1;CS;ACO2;GPI1;HADHAB;DLST;GLDC;RPIA
Proximal tubule bicarbonate reclamationATP1B1;GLS;PCK1;ATP1B4;SLC4A4;GLUD2;AQP1;ATP1A1;ATP1A3

MDH1 has several biochemical functions, for example, L-malate dehydrogenase activity, NAD binding, diiodophenylpyruvate reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDH1 itself. We selected most functions MDH1 had, and list some proteins which have the same functions with MDH1. You can find most of the proteins on our site.

Function Related Protein
L-malate dehydrogenase activityMDH1AA;MDH1;MDH2
NAD bindingNDUFS2;GRHPRA;ME3;HIBADHA;IDH1;IDH3A;GPD1B;IDH2;ADH4
diiodophenylpyruvate reductase activity
malic enzyme activityMDH1;ME1;ME3;ME2
protein bindingZNF276;C4BPB;IRS2;BCCIP;LTBR;BBS13;PI4K2A;NASP;PARP2

MDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDH1.

TERF1; EGFR; FUS; MPP3; TERF2IP; HSP90AB1; IQCB1; ATG5

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