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Official Full Name mediator complex subunit 7
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.
Synonyms MED7; mediator complex subunit 7; cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa , CRSP9; mediator of RNA polymerase II transcription subunit 7; CRSP33; Activator recruited cofactor 34 kDa component; ARC34; Cofactor required for Sp1 transcriptional activation subunit 9; MGC12284; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33; hMED7; OTTHUMP00000160735; CRSP complex subunit 9; activator-recruited cofactor 34 kDa component; RNA; CRSP9
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED7-1121H Recombinant Human MED7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MED7-1910H Recombinant Human MED7 Protein, GST-tagged Wheat Germ GST
    Human MED7-26939TH Recombinant Human MED7 N/A
    Human MED7-4379HCL Recombinant Human MED7 293 Cell Lysate HEK293 N/A
    Mouse MED7-9706M Recombinant Mouse MED7 Protein Mammalian Cell His
    Zebrafish MED7-10132Z Recombinant Zebrafish MED7 Mammalian Cell His

    med7 involved in several pathways and played different roles in them. We selected most pathways med7 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with med7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology EPHA10; NADL1.1; AP2A1; MYOD1; HELZ2; KLB; ARHGEF28; CDON; EPHB3A; ACTR2
    Fatty acid, triacylglycerol, and ketone body metabolism ACOT12; ACAD11; CDK19; PLIN2; CYP7A1; SREBF2; MED19; HELZ2; STIL; TIAM2
    Gene Expression ZNF221; GTF3C2; HNRNPA0B; EIF2C3; NFIA; EEF1E1; POLR3C; ZNF565; ADARB1A; CCNT2A
    Generic Transcription Pathway ZNF23; NR5A1B; ZNF566; NRBF2; ZNF726; C7orf59; ZIM2; ZNF155; ZNF573; ZNF266
    Metabolism CSPG5B; OAZ1A; CERS3B; TIAM2; B3GNT2; NFYAL; ADH8B; SLC25A14; SLC23A2; PNP5B
    Metabolism of lipids and lipoproteins CYP2N13; ACOT9.2; SACM1LB; ARSH; VAPB; CERS4A; SLC44A5B; CPTP; CYP27B1; PPM1LA
    PPARA activates gene expression CTGF; MTF1; MED26; MED29; APOA5; MED15; GLIPR1; ANKRD1; CDK19; MED21
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) CTGF; G0S2; MED18; ANKRD1; MED21; MED22; MED15; GLIPR1; MED20; MED26

    med7 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by med7 itself. We selected most functions med7 had, and list some proteins which have the same functions with med7. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity PPARGC1A; MED21; MED31; MED20; FOXH1; NKX2; CRSP7; MED13B; MED1; MED14
    protein binding CST5; CHMP6; CFH; BPIFA2; PSIP1; TGM1; NLRC5; SYT4; TTC6; HDAC10
    transcription coactivator activity CALCOCO1; TAF11; THRAP3; MED16; MED6; TAF12; MED26; GATA4; HAND1; MED7
    ubiquitin protein ligase activity RNF34; SYVN1; ANKIB1A; CDC42; RNF6; UBE2G1; MED31; RNF217; UBE2V1; UBR2

    med7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with med7 here. Most of them are supplied by our site. Hope this information will be useful for your research of med7.

    MED10; MED26; MED19; env; CDK19; MED9

    Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
    Sendler, M; Dummer, A; et al. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. GUT 62:430-439(2013).

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