MGAT1 Protein


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Official Full Name mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Background There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.
Synonyms MGAT1; mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; GLYT1, MGAT; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; GLCNAC TI; GNT 1; glcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosam;
    • Species :
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Oryctolagus cuniculus (Rabbit)
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.coli expression system
    • E.Coli or Yeast
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • N/A
    • N-6×His, GFP
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MGAT1-1703H Recombinant Human MGAT1 Protein, His-tagged E.coli His Inquiry
    Human MGAT1-29206TH Recombinant Human MGAT1 Wheat Germ N/A Inquiry
    Mouse Mgat1-3294M Recombinant Mouse Mgat1, His-tagged E.Coli or Yeast His Inquiry
    Mouse MGAT1-9807M Recombinant Mouse MGAT1 Protein Mammalian Cell His Inquiry
    Rat MGAT1-3668R Recombinant Rat MGAT1 Protein Mammalian Cell His Inquiry
    Rhesus Macaque MGAT1-2759R Recombinant Rhesus monkey MGAT1 Protein, His-tagged Mammalian Cell His Inquiry
    Human MGAT1-4343HCL Recombinant Human MGAT1 293 Cell Lysate HEK293 N/A Inquiry
    Human MGAT1-09H Recombinant Human MGAT1 Protein (AA 30-445), N-6×His/GFP tagged HEK293 N-6×His, GFP Inquiry
    Rhesus Macaque MGAT1-2580R Recombinant Rhesus Macaque MGAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rat MGAT1-3324R Recombinant Rat MGAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MGAT1-3472H Recombinant Human MGAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Mouse MGAT1-5532M Recombinant Mouse MGAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MGAT1-6205HF Recombinant Full Length Human MGAT1 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Homo sapiens (Human) RFL15188HF Recombinant Full Length Human Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase(Mgat1) Protein, His-Tagged E.coli expression system His Inquiry
    Mus musculus (Mouse) RFL16686MF Recombinant Full Length Mouse Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase(Mgat1) Protein, His-Tagged E.coli expression system His Inquiry
    Oryctolagus cuniculus (Rabbit) RFL23098OF Recombinant Full Length Rabbit Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase(Mgat1) Protein, His-Tagged E.coli expression system His Inquiry
    Human MGAT1-1704H Recombinant MGAT1 Protein, His-tagged Mammalian cells His Inquiry
    Human MGAT1-4371H Recombinant Human MGAT1 Protein, GST-tagged Wheat Germ GST Inquiry

    MGAT1 involved in several pathways and played different roles in them. We selected most pathways MGAT1 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    N-Glycan biosynthesis MGAT1; DOLK; B4GALT3; DPM1; MAN1A; ST6GAL1; ALG11; ALG3; MGAT2; FUT8
    Metabolic pathways UCK2; AMT; HYKK; FUT1; MTHFD2L; GALNTL6; INPP5A; FUT4; PPAP2D; DLAT

    MGAT1 has several biochemical functions, for example, acetylglucosaminyltransferase activity, alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT1 itself. We selected most functions MGAT1 had, and list some proteins which have the same functions with MGAT1. You can find most of the proteins on our site.

    Function Related Protein
    acetylglucosaminyltransferase activity B3GNT9-PS; POC1BL; C3orf39; GTDC2; GLT8D1; B3GALNT2; XYLT2; A4GNT; B3GNT8; DPY19L4
    alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity MGAT1
    metal ion binding NEK5; ZSCAN4F; SP3A; CDKAL1; PDE5A; WBSCR17; GNAT3; ZFP36L2; WBP4; PPP1R10

    MGAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT1.

    SMAD9; MAPK6; Anapc13; Mus81; Mad2l1

    Sealover, NR; Davis, AM; et al. Engineering Chinese Hamster Ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1). JOURNAL OF BIOTECHNOLOGY 167:24-32(2013).
    Williams, SA; Stanley, P; et al. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo. GLYCOCONJUGATE JOURNAL 26:335-347(2009).

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