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MKRN1

Official Full Name

makorin ring finger protein 1
Overview

The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of;intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the;MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000 (PubMed 10843807)).
Synonyms

MKRN1; makorin ring finger protein 1; E3 ubiquitin-protein ligase makorin-1; RNF61; RING finger protein 61; FLJ21334;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Flag
GST
His
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MKRN1-895H	Recombinant Human MKRN1, GST-tagged	E.coli	GST	N-term-349aa	$319 / 25ug
Human	MKRN1-4300HCL	Recombinant Human MKRN1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MKRN1-022H	Recombinant Human MKRN1 Protein, Flag-tagged	HEK293	Flag		Inquiry
Human	MKRN1-6343HF	Recombinant Full Length Human MKRN1 Protein, GST-tagged	In Vitro Cell Free System	GST	482 amino acids	Inquiry
Human	MKRN1-5372H	Recombinant Human MKRN1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MKRN1-3380H	Recombinant Human MKRN1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Mkrn1-4085M	Recombinant Mouse Mkrn1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	MKRN1-9444Z	Recombinant Zebrafish MKRN1	Mammalian Cell	His		Inquiry
Chicken	MKRN1-6307C	Recombinant Chicken MKRN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MKRN1 involved in several pathways and played different roles in them. We selected most pathways MKRN1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKRN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	ASB14;KIF5B;KIF4;CD200R4;AP1S3A;TRIM9;ITGB1B.1;CYBA;Mill2
Antigen processing: Ubiquitination &amp	TRIM9;ASB13;NPEPPS;RNF182;UBR1;STUB1;SPSB2;ASB9;RNF25
Proteasome degradation	SH3RF1;FBXO3;ASB13;UBE2V2;RNF182;TRIM63;ARIH2;DTX3L;TRIM41
Class I MHC mediated antigen processing &amp	FBXO27;RBCK1;RNF111;UBE2F;UBE2V2;TPP2;TRIM41;ASB14;KLHL21
presentation	ERAP2;ASB2;CYBA;UBE2J2;FBXO27;TRIM41;SEC23A;ATG7;LRR1
Immune System	LRRC41;RNF182;ABI1A;WASF3;IFI27;HERC5;NLRC5;NLRP4;SH2D1B

MKRN1 has several biochemical functions, for example, chromatin binding, ligase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKRN1 itself. We selected most functions MKRN1 had, and list some proteins which have the same functions with MKRN1. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	LEF1;HDGFRP2;FEZF2;SSRP1;FOXC1A;REL;ZFP354B;SP140;SMARCD1
ligase activity	UBR5;MGRN1;RFWD2;MARCH5L;ACSM2;BTRC;MEX3C;UBE2I;BARD1
poly(A) RNA binding	FLYWCH2;YARS2;DQX1;DHX38;PES1;TRAP1;DSP;SUPT6H;SLBP
protein binding	AP4M1;PSMC1;CRYBB3;MT3;IFI35;KRT6C;GZMM;SEPT1;C14orf166
ubiquitin-protein transferase activity	UBA1;IRAK1;ARIH2;SKP1;TRIM36;UBR3;HECTD3;MARCH5L;BIRC3
zinc ion binding	KDM2A;RNF133;FBXO30;THRB;APOBEC3D;DPF2;PCGF6;PDLIM3A;PHC1

MKRN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKRN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKRN1.

TP53; CDKN1A; UBC; UBE2D3; ctc; X; UBE2W; EXOSC8; DUSP23