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Recombinant Mouse MMP24 Protein (42-575 aa), His-Myc-tagged

Cat.No. : MMP24-2455M
Product Overview : Recombinant Mouse MMP24 Protein (42-575 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Cell Biology. Protein Description: Partial.
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Description : Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.
Source : E. coli
Species : Mouse
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 66.4 kDa
Protein length : 42-575 aa
AA Sequence : AGKPAGADAPFAGQNWLKSYGYLLP YESRASALHSGKALQSAVSTMQQFY GIPVTGVLDQTTIEWMKKPRCGVPD HPHLSRRRRNKRYALTGQKWRQKHI TYSIHNYTPKVGELDTRKAIRQAFD VWQKVTPLTFEEVPYHEIKSDRKEA DIMIFFASGFHGDSSPFDGEGGFLA HAYFPGPGIGGDTHFDSDEPWTLGN ANHDGNDLFLVAVHELGHALGLEHS NDPSAIMAPFYQYMETHNFKLPQDD LQGIQKIYGPPAEPLEPTRPLPTLP VRRIHSPSERKHERHPRPPRPPLGD RPSTPGAKPNICDGNFNTVALFRGE MFVFKDRWFWRLRNNRVQEGYPMQI EQFWKGLPARIDAAYERADGRFVFF KGDKYWVFKEVTVEPGYPHSLGELG SCLPREGIDTALRWEPVGKTYFFKG ERYWRYSEERRATDPGYPKPITVWK GIPQAPQGAFISKEGYYTYFYKGRD YWKFDNQKLSVEPGYPRNILRDWMG CKQKEVERRKERRLPQDDVDIMVTI DDVPGSVNA
Purity : > 85% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Gene Name : Mmp24 matrix metallopeptidase 24 [ Mus musculus ]
Official Symbol : MMP24
Synonyms : MMP24; matrix metallopeptidase 24; MMP-21; MMP-24; MT-MMP 5; membrane type 5-MMP; MT5MMP; MTMMP5; MT5-MMP; AU040325;
Gene ID : 17391
mRNA Refseq : NM_010808
Protein Refseq : NP_034938
UniProt ID : Q9R0S2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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