MRPL40
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Official Full Name
mitochondrial ribosomal protein L40
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Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. -
Synonyms
MRPL40; mitochondrial ribosomal protein L40; NLVCF, nuclear localization signal deleted in velocardiofacial syndrome; 39S ribosomal protein L40, mitochondrial; MRP L22; mitochondrial; 39S ribosomal protein L40; 39S ribosomal protein L40, mitochondrial precursor; FLJ41774; L40mt; MGC9400; MRP 40; MRP-L40; MRP40; MRPL22; NLVCF; Nuclear localization signal containing protein deleted in velocardiofacial syndrome; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; RM40_HUMAN; Up-regulated in metastasis; URIM; nuclear localization signal deleted in velocardiofacial syndrome; MRP-L22;
- Involved Pathway
- Protein Function
- Interacting Protein
MRPL40 involved in several pathways and played different roles in them. We selected most pathways MRPL40 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation | MRPL46;MRPS23;MRPS22;MRPL52;MRPL38;MRPL10;GFM2;MRPS28;MRPL40 |
| Mitochondrial translation elongation | MRPL50;MRPS36;DAP3;MRPL40;MRPS23;MRPS22;MRPS28;MRPS33;MRPL46 |
| Mitochondrial translation initiation | MRPL55;MRPL50;MRPS24;DAP3;MRPL42;MRPL48;MRPS31;MRPL37;CHCHD1 |
| Mitochondrial translation termination | MRPS30;MRPL42;MRPS22;AURKAIP1;MRPL52;MRPL50;PTCD3;MRPL53;MRPL54 |
| Organelle biogenesis and maintenance | MRPL52;MRPS31;KIFAP3B;MRPL53;TTC30A;BBS10;TFB2M;IFT22;TCTN3 |
MRPL40 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL40 itself. We selected most functions MRPL40 had, and list some proteins which have the same functions with MRPL40. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | POLR2A;RBM27;MDH2;UBE2N;HTATSF1;PSMD4;ACAA2;U2AF1;TNRC6B |
| protein binding | JAM2A;HRG;GTF2F1;NPRL2;FGF3;OLFM1;CTSC;POLD4;STAM |
MRPL40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL40 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL40.
TRIM27; TFCP2; KRT31; NOTCH2NL; HLA-B; USP44; HSPB1; ssrna_ug
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