• Official Full Name

    mitochondrial ribosomal protein L40

  • Background

    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.
  • Synonyms

    MRPL40; mitochondrial ribosomal protein L40; NLVCF, nuclear localization signal deleted in velocardiofacial syndrome; 39S ribosomal protein L40, mitochondrial; MRP L22; mitochondrial; 39S ribosomal protein L40; 39S ribosomal protein L40, mitochondrial precursor; FLJ41774; L40mt; MGC9400; MRP 40; MRP-L40; MRP40; MRPL22; NLVCF; Nuclear localization signal containing protein deleted in velocardiofacial syndrome; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; RM40_HUMAN; Up-regulated in metastasis; URIM; nuclear localization signal deleted in velocardiofacial syndrome; MRP-L22;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MRPL40-6419HF Recombinant Full Length Human MRPL40 Protein, GST-tagged In Vitro Cell Free System GST
    Human MRPL40-1003H Recombinant Human MRPL40, GST-tagged E.coli GST
    Human MRPL40-4169HCL Recombinant Human MRPL40 293 Cell Lysate HEK293 N/A
    Human MRPL40-146H Recombinant Human MRPL40, His-tagged HEK293 His
    Human MRPL40-5584H Recombinant Human MRPL40 Protein, GST-tagged Wheat Germ GST
    Rat MRPL40-3432R Recombinant Rat MRPL40 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat MRPL40-3773R Recombinant Rat MRPL40 Protein Mammalian Cell His
    Rat MRPL40-3432R-B Recombinant Rat MRPL40 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque MRPL40-2665R Recombinant Rhesus Macaque MRPL40 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque MRPL40-2845R Recombinant Rhesus monkey MRPL40 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque MRPL40-2665R-B Recombinant Rhesus Macaque MRPL40 Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish MRPL40-1331Z Recombinant Zebrafish MRPL40 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    MRPL40 involved in several pathways and played different roles in them. We selected most pathways MRPL40 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial translationMRPL46;MRPS23;MRPS22;MRPL52;MRPL38;MRPL10;GFM2;MRPS28;MRPL40
    Mitochondrial translation elongationMRPL50;MRPS36;DAP3;MRPL40;MRPS23;MRPS22;MRPS28;MRPS33;MRPL46
    Mitochondrial translation initiationMRPL55;MRPL50;MRPS24;DAP3;MRPL42;MRPL48;MRPS31;MRPL37;CHCHD1
    Mitochondrial translation terminationMRPS30;MRPL42;MRPS22;AURKAIP1;MRPL52;MRPL50;PTCD3;MRPL53;MRPL54
    Organelle biogenesis and maintenanceMRPL52;MRPS31;KIFAP3B;MRPL53;TTC30A;BBS10;TFB2M;IFT22;TCTN3

    MRPL40 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL40 itself. We selected most functions MRPL40 had, and list some proteins which have the same functions with MRPL40. You can find most of the proteins on our site.

    Function Related Protein
    protein bindingJAM2A;HRG;GTF2F1;NPRL2;FGF3;OLFM1;CTSC;POLD4;STAM

    MRPL40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL40 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL40.

    TRIM27; TFCP2; KRT31; NOTCH2NL; HLA-B; USP44; HSPB1; ssrna_ug

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