myc
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  • Official Full Name
  • v-myc avian myelocytomatosis viral oncogene homolog
  • Background
  • The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitts lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MYC; v-myc avian myelocytomatosis viral oncogene homolog; MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor;
Cat.#:MYC-5787HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYC Protein, GST-tagged
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Cat.#:MYC-1028HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MYC
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Cat.#:MYC-1029HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC, His-tagged
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Cat.#:MYC-152HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC tag protein
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Cat.#:MYC-2522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC, His-tagged
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Cat.#:MYC-254HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC protein, T7/His-tagged
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Cat.#:MYC-26HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MYC protein, MYC/DDK-tagged
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Cat.#:MYC-3627HTag:11R Tag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC protein, 11R-tagged
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Cat.#:MYC-38HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC, His-tagged
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Cat.#:MYC-39HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC, Arg-tagged
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Cat.#:MYC-574HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC protein, His & GST-tagged
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Cat.#:MYC-79HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYC protein, arginine-tagged
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Cat.#:Myc-6774MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Myc protein, His & GST-tagged
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Cat.#:Myc-71MTag:Arg
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Myc, Arg-tagged
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Cat.#:MYC-3839RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYC Protein
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Cat.#:MYC-2916RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MYC Protein, His-tagged
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Cat.#:MYC-2641CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYC
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Cat.#:MYC-4039HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYC 293 Cell Lysate
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Cat.#:Kit-1785Tag:
Source (Host):Species:
Product nameMyc Reporter Kit (Myc Signaling Pathway)
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Involved Pathway

MYC involved in several pathways and played different roles in them. We selected most pathways MYC participated on our site, such as Acute myeloid leukemia, Apoptosis, Binding of TCF/LEF:CTNNB1 to target gene promoters, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Acute myeloid leukemia
FLT3; MYC; RAF1; SOS1; MAPK3; PIM2; PIK3R1; MTOR; PIK3CG; AKT3
Apoptosis
IRAK3; CASP8; ADD1; CASP9; DBNL; BAX; CYCSB; SATB1; TNFRSFA; PRKACBA
Binding of TCF/LEF:CTNNB1 to target gene promoters
MYC
Bladder cancer
MAP2K2; CDH1; RAF1; E2F1; SRC; MYC; HRAS; DAPK2; HBEGF; NRAS
C-MYB transcription factor network
MYF6; TOM1; ADA; GATA1; PRTN3; PPID; CREBBP; CDK6; CEBPB; CLTA
C-MYC pathway
RUVBL2; KAT5; HBP1; ACTL6A; MYC
CD40/CD40L signaling
MYC; TDP2; JAK3
Cell Cycle
KIF20A; TUBGCP3; KIF2B; RBL2; ACTR1A; CDH1-A; AKAP9; CENPA; ORC3L; CENPI

Protein Function

MYC has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYC itself. We selected most functions MYC had, and list some proteins which have the same functions with MYC. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ESRRGA; NKX2.1; POLG; RPAP1; ZFP553; LTF; ZNF276; ZNF326; ZBTB22; SOX1
Function E-box binding
Related Protein TWIST1; ASCL2; AHR; ZEB1; TAL1; ASCL1; LMO2; TCF3; MYC; PER1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MEIS1; MEOX1; FEZF2; SOX1; MYPOP; HOXC11; LEF1; PAXBP1; ZSCAN21; ZNF502
Function protein binding
Related Protein PROP1; PTGES3; CCDC109A; MAP1LC3C; C16orf87; GAL; TXLNG; ZNF460; CHD; HEXIM1
Function protein complex binding
Related Protein FYB; ANKRD32; PRMT5; PDZK1; ITGB1BP1; HADHA; WRN; TRAF2; NDUFA4; MTAP1B
Function protein dimerization activity
Related Protein GRIN2A; SCXA; NCOA3; NEUROG1; ABCG1; SREBF2; MSGN1; STK4; MNT; HER13
Function repressing transcription factor binding
Related Protein ARNTL; TLE4; CTBP1; TBP; TCF3; CBX5; HHEX; GMNN; SRI; MYC
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOXD4; ZNF792; IRF3; GATAD1; STAT3; SMAD6; ELF2; ZFP14; PA2G4; GPBP1
Function transcription factor binding
Related Protein E2F4; TFAP2A; CCND1; Ar; APBB1; GPX3; PRICKLE1; YWHAZ; MED1; DRG1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SOX4; MYB; CREB3L2; MYBL2; HIF1A; EGR1; NUCKS1; NEUROD1; NFATC2; PGR

Interacting Protein

MYC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYC here. Most of them are supplied by our site. Hope this information will be useful for your research of MYC.
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MYC Related Articles

Raha, Paromita; Thomas, Scott; et al. Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen resistant breast cancer models, by reversing Bcl-2 overexpression.. Breast cancer research : BCR 17:533-533(2015).
Li, Dan; Mei, Hong; et al. Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2.. Molecular cancer 14:320-320(2015).