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Official Full Name myosin, light chain 7, regulatory
Background Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin bindingand potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domainthat binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interactswith cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatorymyosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It isinvolved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating acontractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and byintracellular Ca2+ concentrations.Gene Wiki entry for MYL7.
Synonyms MYL7; myosin, light chain 7, regulatory; myosin, light polypeptide 7, regulatory; myosin regulatory light chain 2, atrial isoform; MYL2A; MYLC2A; atrial isoform; MLC-2a; MLC2a; MLRA_HUMAN; Myosin light chain 2a; Myosin regulatory light chain 2; Myosin regulatory light chain 7
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MYL7-3699H Recombinant Human MYL7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Myl7-4255M Recombinant Mouse Myl7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MYL7-4021HCL Recombinant Human MYL7 293 Cell Lysate HEK293 N/A
    Human MYL7-5816H Recombinant Human MYL7 Protein, GST-tagged Wheat Germ GST
    Human MYL7-6780H Recombinant Human Myosin, Light Chain 7, Regulatory, His-tagged E.coli His
    Zebrafish MYL7-8916Z Recombinant Zebrafish MYL7 Mammalian Cell His

    myl7 involved in several pathways and played different roles in them. We selected most pathways myl7 participated on our site, such as Focal adhesion, Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with myl7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Tight junction CLDNA; TJP1; ACTB; AKT2; CLDN14; CLDNK; PARD6GA; MYLPFB; MYH11; MYH13
    Leukocyte transendothelial migration MYL7; CLDN16; RHOH; MAPK12; BCAR1; THY1; PXN; ICAM1; RAC2; MYL9
    Regulation of actin cytoskeleton RDX; ACTN3; PTK2; BRK1; MAP2K1; GNA13A; TMSB4Y; BDKRB1; SSH2; PPP1CC

    myl7 has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by myl7 itself. We selected most functions myl7 had, and list some proteins which have the same functions with myl7. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding S100A5; VSNL1; SYTL3; MYL9A; EFCAB10; KCNIP3A; TESC; SULF2B; JAG1B; DLK2
    protein binding ESRRA; HDAC1; SEPT9; EGF; AZGP1; NDRG1; ERP29; CPNE6; SPAG9; SOCS2

    myl7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with myl7 here. Most of them are supplied by our site. Hope this information will be useful for your research of myl7.


    Sheykhani, R; Shirodkar, PV; et al. The role of myosin phosphorylation in anaphase chromosome movement. EUROPEAN JOURNAL OF CELL BIOLOGY 92:175-186(2013).
    Kakei, T; Sumiyoshi, H; et al. Characteristics of light chains of Chara myosin revealed by immunological investigation. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 88:201-211(2012).

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