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MYLK

  • Official Full Name

    myosin light chain kinase

  • Overview

    This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3 region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
  • Synonyms

    MYLK; myosin light chain kinase; myosin, light polypeptide kinase; myosin light chain kinase, smooth muscle; MLCK; MLCK1; MYLK1; smMLCK; smooth muscle myosin light chain kinase; telokin; kinase-related protein; KRP; AAT7; MLCK108; MLCK210; MSTP083; FLJ122;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His|GST
  • His|T7
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYLK-1509H Recombinant Human MYLK protein, His & GST-tagged E.coli His/GST Phe1661~Asp1877 (Accession # Q15746)
Human MYLK-696H Recombinant Human Myosin Light Chain Kinase, GST-tagged Insect Cell GST
Human MYLK-27838TH Recombinant Human MYLK N/A
Human MYLK-355H Recombinant Human Myosin Light Chain Kinase, GST-tagged, Active Sf9 Insect Cell GST
Human MYLK-4017HCL Recombinant Human MYLK 293 Cell Lysate HEK293 N/A
Human MYLK-4858H Recombinant Human MYLK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MYLK-5820H Recombinant Human MYLK Protein, GST-tagged Wheat Germ GST
Human MYLK-5954H Recombinant Human MYLK protein, His-tagged E.coli His 1464-1719aa
Human MYLK-6768HF Recombinant Full Length Human MYLK Protein, GST-tagged In Vitro Cell Free System GST 992 amino acids
Human MYLK-4651H Recombinant Human MYLK Protein (Thr1748-Glu1914), N-His tagged E.coli N-His Thr1748-Glu1914
Mouse Mylk-1510M Recombinant Mouse Mylk protein, His & T7-tagged E.coli His/T7 Met1684~Asp1884 (Accession # Q6PDN3)
Mouse Mylk-335M Recombinant Mouse Mylk Protein, MYC/DDK-tagged HEK293T MYC/DDK
Chicken MYLK-7009C Recombinant Chicken MYLK Mammalian Cell His
Chicken Mylk-3878C Recombinant Chicken Mylk protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 1435-1722aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MYLK involved in several pathways and played different roles in them. We selected most pathways MYLK participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayCALML3;TRHR;CHRM3;F2R;ADCY2B;AGTR1;HTR2CL1;PLCD3A;SLC8A2B
cGMP-PKG signaling pathwayNOS3;IRS2;ATP1A2;PPP3CA;VDAC3;ATP1B2;ATP1B3;LOC100328615;NPPB
Vascular smooth muscle contractionPPP1CB;PPP1R14AB;CALML5;GNA11B;MYL6;PRKCDA;CALD1;PRKCBB;PRKCD
Focal adhesionTHBS3;PIK3CB;ACTN4;MET;RHOAC;ACTB;RAP1AA;TNK2;SRMS
Platelet activationGP1BB;PRKACA;VWF;GNAI1;PLA2G4A;FCER1G;GP9;GNAQ;ARHGEF12
Regulation of actin cytoskeletonCHRM5A;CHRM2A;RAF1A;ITGA9;PIK3R3B;GNA13A;PIK3CD;MSN;ROCK2B
Oxytocin signaling pathwayMYL6;ELK1;GUCY1B3;EEF2K;PRKAB1;PPP1CA;PLA2G4A;RHOA;CACNA2D2
Gastric acid secretionAdcy4;SLC26A7;MYLK3;PLCB1;PLCB4;KCNJ2;MYLK;CAMK2B;ATP1A3

MYLK has several biochemical functions, for example, ATP binding, actin binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK itself. We selected most functions MYLK had, and list some proteins which have the same functions with MYLK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSARS;DCLK1;CHD1L;LCK;WARS;SGK2B;MAP2K7;ABCB3L1;PRPF4BB
actin bindingLMOD1;PARVB;EZR;MYH1;DSTN;DMTN;Fert2;BAIAP2L1;PARVAB
calmodulin bindingNDUFAF4;MYO5C;MYH1E;SRY;SPHK1;SNTA1;MAPKAPK2A;SLC8A2;TRPV6
metal ion bindingPLEKHF1;ZNF404;FTR67;SCD5;POLA1;ARSJ;CFI;SCRT2;ITGB2
myosin light chain kinase activityMYLK;MYLK3;MYLK2
protein bindingRALGDS;LRRC29;ANGPT1;HRK;HMMR;ZFYVE20;SFRP4;F11;FCER1G

MYLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK.

GOPC; MYL12A; NCK1; PIK3R1; GRB2; CTTN; HSPB1; q7ard3_yerpe; q7cje7_yerpe; ahpC; exuR; tbpA1; q8d0g3_yerpe; npm_alk

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