NCOA4
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Official Full Name
nuclear receptor coactivator 4
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Overview
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. -
Synonyms
NCOA4; nuclear receptor coactivator 4; ARA70; DKFZp762E1112; ELE1; PTC3; RET activating gene ELE1; RFG; NCoA-4; ret fused; 70 kDa AR-activator; RET-activating gene ELE1; 70 kDa androgen receptor coactivator; androgen receptor-associated protein of 70 kDa;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- C
- Myc
- DDK
- His
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | NCOA4-1214H | Recombinant Human NCOA4, His-tagged | E.coli | His | N-term-400aa | |
Human | NCOA4-3940HCL | Recombinant Human NCOA4 293 Cell Lysate | HEK293 | N/A | ||
Human | NCOA4-423H | Recombinant Human NCOA4 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK | ||
Mouse | Ncoa4-4315M | Recombinant Mouse Ncoa4 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Zebrafish | NCOA4-11351Z | Recombinant Zebrafish NCOA4 | Mammalian Cell | His | ||
Chicken | NCOA4-1634C | Recombinant Chicken NCOA4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- NCOA4 Related Articles
NCOA4 involved in several pathways and played different roles in them. We selected most pathways NCOA4 participated on our site, such as Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pathways in cancer | WNT8B;FGF4;PDGFRA;PTK2;WNT11;WNT1;MAPK3;MITF;FGF11 |
Thyroid cancer | LEF1;PAX8;MAP2K1;MAP2K2;RXRG;MAPK1;KRAS;RXRB;TP53 |
NCOA4 has several biochemical functions, for example, androgen receptor binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA4 itself. We selected most functions NCOA4 had, and list some proteins which have the same functions with NCOA4. You can find most of the proteins on our site.
Function | Related Protein |
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androgen receptor binding | NCOA1;TCF21;CALR;PRPF6;NCOA4;RB1;PRKCBB;TGFB1I1;FOXH1 |
transcription coactivator activity | GTF2A2;RAP2C;ATXN7L3;CITED4;SUB1B;SUB1A;BRD7;ESR2;YAP1 |
NCOA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA4.
AR; AKT1; q81sn0_bacan; spoIVA; ATXN2; PSMD14; PSMC1; USP43; Psmd6
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