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Official Full Name nicastrin
Background This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Synonyms NCSTN; nicastrin; ATAG1874; anterior pharynx-defective 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Rabbit
    • Tag :
    • Fc
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11585RH Rabbit Monoclonal Antibody to Human Nicastrin Rabbit N/A
    Human NCSTN-1217H Recombinant Human NCSTN, His-tagged E.coli His
    Human NCSTN-2316H Recombinant Human NCSTN, His tagged Human Cell His
    Human NCSTN-2528HCL Recombinant Human NCSTN cell lysate Human Cell N/A
    Human NCSTN-469H Recombinant Human NCSTN Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse NCSTN-1380MCL Recombinant Mouse NCSTN cell lysate Human Cell N/A
    Mouse Ncstn-4319M Recombinant Mouse Ncstn Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Ncstn-7406M Recombinant Mouse Ncstn, His tagged Human Cell His
    Mouse Ncstn-8687M Recombinant Mouse Ncstn, Fc tagged Human Cell Fc
    Rat NCSTN-3925R Recombinant Rat NCSTN Protein Mammalian Cell His
    Rat Ncstn-7993R Recombinant Rat Ncstn protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque NCSTN-2962R Recombinant Rhesus monkey NCSTN Protein, His-tagged Mammalian Cell His
    Chicken NCSTN-1231C Recombinant Chicken NCSTN Mammalian Cell His
    Zebrafish NCSTN-1946Z Recombinant Zebrafish NCSTN Mammalian Cell His

    ncstn involved in several pathways and played different roles in them. We selected most pathways ncstn participated on our site, such as Notch signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ncstn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway RBPJA; APH1B; RBPJB; HER6; DLB; DTX1; HDAC2; KAT2A; HES1; LNX1
    Alzheimers disease CDK5R1; CDK5; ATP5G3; PLCB2; ATP5J; UQCRH; CASP8; GNAQ; NDUFC2; NDUFS3

    ncstn has several biochemical functions, for example, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ncstn itself. We selected most functions ncstn had, and list some proteins which have the same functions with ncstn. You can find most of the proteins on our site.

    Function Related Protein
    endopeptidase activity MME; KLK1B5; PARL; KLK1B24; SENP3; PSEN2; PSMA5; FURIN; PSMA2; SENP3A
    protein binding CSPP1; FAM72A; STXBP3; NOS2; CALM2; OGN; PLEKHG2; GCET2; TBX15; ANKFY1

    ncstn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ncstn here. Most of them are supplied by our site. Hope this information will be useful for your research of ncstn.


    Filipovic, A; Lombardo, Y; et al. Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells. BREAST CANCER RESEARCH AND TREATMENT 148:455-462(2014).

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