ncstn
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  • Official Full Name
  • nicastrin
  • Background
  • This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
  • Synonyms
  • NCSTN; nicastrin; ATAG1874; anterior pharynx-defective 2;
Cat.#:NCSTN-469HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NCSTN Protein, MYC/DDK-tagged
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Cat.#:NCSTN-1217HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCSTN, His-tagged
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Cat.#:NCSTN-2316HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NCSTN, His tagged
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Cat.#:Ncstn-7406MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ncstn, His tagged
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Cat.#:Ncstn-8687MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ncstn, Fc tagged
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Cat.#:NCSTN-3925RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NCSTN Protein
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Cat.#:Ncstn-7993RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ncstn protein, His & T7-tagged
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Cat.#:NCSTN-2962RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NCSTN Protein, His-tagged
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Cat.#:NCSTN-1231CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NCSTN
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Cat.#:NCSTN-1946ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NCSTN
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Cat.#:NCSTN-2528HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NCSTN cell lysate
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Cat.#:NCSTN-1380MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse NCSTN cell lysate
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NCSTN Related Articles

Filipovic, A; Lombardo, Y; et al. Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells. BREAST CANCER RESEARCH AND TREATMENT 148:455-462(2014).