• Official Full Name

    neurofilament, light polypeptide

  • Overview

    Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role;in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations;in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous;system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
  • Synonyms

    NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • bovine Spinal Cord
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO|Myc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEFL-182H Recombinant human NEFL E.coli N/A
Human NEFL-13H Recombinant Human NEFL protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NEFL-12H Recombinant Human NEFL, GST-tagged Wheat Germ GST
Human NEFL-1292H Recombinant Human NEFL Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Human NEFL-26033TH Recombinant Human NEFL, His-tagged E.coli His
Human NEFL-1255H Recombinant Human NEFL, His-tagged E.coli His
Human NEFL-3884HCL Recombinant Human NEFL 293 Cell Lysate HEK293 N/A
Human NEFL-23H Recombinant Human NEFL Protein, His-tagged E.coli His
Human NEFL-2484H Recombinant Human NEFL Protein, His-tagged E.coli N-His
Human NEFL-2483H Recombinant Human NEFL Protein, His-tagged E.coli N-His
Human NEFL-7008HF Recombinant Full Length Human NEFL Protein, GST-tagged In Vitro Cell Free System GST
Human NEFL-526H Recombinant Human NEFL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NEFL-4679H Recombinant Human NEFL Protein (Met1-Asn352), N-His tagged E.coli N-His
Human NEFL-233H Recombinant Human NEFL Protein (Ser2-Asp543), N-His-SUMO tagged, Animal-free, Carrier-free E.coli N-His-SUMO
Mouse NEFL-10563M Recombinant Mouse Nefl Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Nefl-10M Recombinant Mouse Nefl protein, His-tagged E.coli His
Mouse Nefl-4363M Recombinant Mouse Nefl Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NEFL-1472M Recombinant Mouse NEFL Protein (2-543 aa), His-tagged Yeast His
Mouse Nefl-11M Recombinant Mouse Nefl protein, His-GST-tagged E.coli His/GST
Rat NEFL-3952R Recombinant Rat NEFL Protein Mammalian Cell His
Rat Nefl-5479R Recombinant Rat Nefl protein, His-tagged Yeast His
Rat NEFL-3610R Recombinant Rat NEFL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Nefl-3271R Recombinant Rat Nefl protein, His-tagged E.coli His
Rat NEFL-3610R-B Recombinant Rat NEFL Protein Pre-coupled Magnetic Beads HEK293
Bovine NEFL-181B Native bovine NEFL bovine Spinal Cord N/A
Rhesus Macaque NEFL-2996R Recombinant Rhesus monkey NEFL Protein, His-tagged Mammalian Cell His
Rhesus Macaque NEFL-2815R-B Recombinant Rhesus Macaque NEFL Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NEFL-2815R Recombinant Rhesus Macaque NEFL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig NFL-01P Native Pig NFL Protein (549 AA)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEFL Related Research Area

NEFL involved in several pathways and played different roles in them. We selected most pathways NEFL participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyotrophic lateral sclerosis (ALS)BCL2;MAP2K6;GRIN2D;BCL2L1;DAXX;TOMM40;APAF1;ALS2;CASP12

NEFL has several biochemical functions, for example, identical protein binding, phospholipase binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFL itself. We selected most functions NEFL had, and list some proteins which have the same functions with NEFL. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingATG101;BCHE;PLN;DVL1;PIP4K2C;CSNK2B;BNIP2;ROBO2;IFI16
phospholipase bindingNEFL;PDPK1;CALM1;PRKCZ;Pla2r1;SNCA;DGKQ;APOC2;PTPN11
protein C-terminus bindingCACNA1B;RAD51;VTA1;XRCC4;PEX1;HSPG2;IFT52;KCNIP3;GRIP1
protein binding, bridgingNEFL;TIRAP;FSCN2A;GATAD2A;FGG;DDX20;IVL;BCL3;CAV2
protein domain specific bindingHIST1H4F;NFE2L2;XPA;WNT1;VPS11;HNRNPM;CTBP1;MTOR;CHMP2B
protein heterodimerization activityCA;MEIS1;TOP2A;DMRT3;TGFB3;SIM2;SNX2;TRP53;TAS1R1
structural constituent of cytoskeletonTUBA4A;BICD1;TUBA1B;TUBGCP4;NGS;TUBB4B;MAPT;TUBB;SORBS2

NEFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFL here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFL.


  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the relationship between NEFL and neurofilaments? 02/26/2021

NEFL is the light chain subunit of neurofilaments, crucial for their assembly and function.

How does NEFL contribute to the stability and structure of axons? 08/01/2020

It is a major component of neurofilaments, providing stability and support to axons.

Are there known genetic mutations in NEFL associated with specific neurological conditions? 12/21/2019

Genetic mutations in NEFL have been linked to Charcot-Marie-Tooth disease and other neuropathies.

What is the primary function of NEFL in neuronal cells? 04/05/2019

NEFL plays a crucial role in maintaining the structure and function of neuronal axons.

In which cells or tissues is NEFL predominantly expressed? 12/17/2018

NEFL is predominantly expressed in neurons, particularly in the axons.

What therapeutic strategies are being explored involving NEFL for neurodegenerative diseases? 07/27/2018

Therapeutic strategies are being developed to target NEFL aggregation and dysfunction in neurodegenerative diseases.

How is NEFL implicated in neurodegenerative diseases? 05/13/2018

Abnormal accumulation of NEFL is associated with various neurodegenerative diseases.

Customer Reviews (3)

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