NEFL Protein


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Official Full Name neurofilament, light polypeptide
Background Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role;in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations;in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous;system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Synonyms NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • bovine Spinal Cord
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • Myc/DDK
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NEFL-1255H Recombinant Human NEFL, His-tagged E.coli His
    Human NEFL-1292H Recombinant Human NEFL Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    Human NEFL-12H Recombinant Human NEFL, GST-tagged Wheat Germ GST
    Human NEFL-13H Recombinant Human NEFL protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human NEFL-182H Recombinant human NEFL E.coli N/A
    Human NEFL-26033TH Recombinant Human NEFL, His-tagged E.coli His
    Mouse NEFL-10563M Recombinant Mouse Nefl Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Nefl-10M Recombinant Mouse Nefl protein, His-tagged E.coli His
    Rat NEFL-3952R Recombinant Rat NEFL Protein Mammalian Cell His
    Rhesus Macaque NEFL-2996R Recombinant Rhesus monkey NEFL Protein, His-tagged Mammalian Cell His
    Human NEFL-3884HCL Recombinant Human NEFL 293 Cell Lysate HEK293 N/A
    Human NEFL-2483H Recombinant Human NEFL Protein, His-tagged E.coli N-His
    Human NEFL-2484H Recombinant Human NEFL Protein, His-tagged E.coli N-His
    Rat Nefl-3271R Recombinant Rat Nefl protein, His-tagged E.coli His
    Rat Nefl-5479R Recombinant Rat Nefl protein, His-tagged Yeast His
    Human NEFL-23H Recombinant Human NEFL Protein, His-tagged E.coli His
    Human NEFL-526H Recombinant Human NEFL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse NEFL-1472M Recombinant Mouse NEFL Protein (2-543 aa), His-tagged Yeast His
    Mouse Nefl-4363M Recombinant Mouse Nefl Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Bovine NEFL-181B Native bovine NEFL bovine Spinal Cord N/A

    NEFL involved in several pathways and played different roles in them. We selected most pathways NEFL participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyotrophic lateral sclerosis (ALS) GRIA1; GRIN2C; APAF1; DAXX; PPP3CA; SLC1A2; MAPK14; CCS; MAPK11; TNFRSF1A

    NEFL has several biochemical functions, for example, identical protein binding, phospholipase binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFL itself. We selected most functions NEFL had, and list some proteins which have the same functions with NEFL. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding MCPH1; FHL2; LYZ; SH2B2; SOD1; COIL; EID3; NELL2; PDGFB; BAX
    phospholipase binding CALM1; WAS; ARHGAP6; LMNB1; PARK2; PTPN11; SELE; SERPINB1A; CALM; CALM3
    protein C-terminus binding FOXN3; DLG3; PRKAA1; AGO2; EFHC1; PIAS4; MID1IP1; PDZD3; VPS4A; NPAT
    protein binding MMP15; LNX2; WFIKKN1; USP34; ICAM3; SUN2; NONO; TATDN1; PPP1R37; NLGN3
    protein binding, bridging ANK2; FGG; SH2D1B; BCL3; ANXA1; IVL; TCAP; TJP2; PPP2R3A; FSCN2A
    protein domain specific binding GABRR1; STRN4; RCC2; RARA; TJP2; FOXA3; CHMP2B; TNFAIP1; TUBA1A; HIST1H4N
    protein heterodimerization activity CHRNB4; CHRAC1; BTBD11A; RRAGD; GABPA; MAFA; ANO2; TAP1; HIST2H3C; HIST1H2BI
    structural constituent of cytoskeleton MAPT; ACTR3; TUBA1B; SPTB; TUBA8; TUBG1; TUBA4A; CYLC2; TUBB5; YEATS4

    NEFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFL here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFL.


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