| Official Full Name | neurofilament, light polypeptide |
| Background | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role;in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations;in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous;system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. |
| Synonyms | NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
NEFL involved in several pathways and played different roles in them. We selected most pathways NEFL participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | CYCS; MAP2K6; PRPH; GRIA2; MAP2K3; CCS; CASP9; BAD; PPP3CC; PPP3R2 |
NEFL has several biochemical functions, for example, identical protein binding, phospholipase binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFL itself. We selected most functions NEFL had, and list some proteins which have the same functions with NEFL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SMG9; COMMD1; CLDND; ADIPOR2; CLDN23; MYOM1; LYZ1; BCL2L1; DPP4; HTT |
| phospholipase binding | SERPINB1A; PDPK1; SNCA; CALM3; PRKCZ; Pla2r1; DGKQ; CALM1; PARK2; PTPN11 |
| protein C-terminus binding | VPS4B; TNNI3K; ITPR1; DLG1; FOXN3; MID1IP1; PXK; IFT52; HAND2; DLG4 |
| protein binding | HDC; VSNL1; ANXA7; GAS2L3; CARM1; SEPT3; PRL2C2; RPL27A; TCERG1; MAD2L2 |
| protein binding, bridging | DDX20; LOR; FGG; RAD50; TRIM22; CAV1; STUB1; FLRT2; ANXA1; FKBP4 |
| protein domain specific binding | MTOR; TRP63; RAN; FOXH1; HIST1H4J; HIST1H4I; NDE1; HIST1H4K; GABRR2; SP100 |
| protein heterodimerization activity | CEBPB; IKZF1; TFAP2B; ZHX1; POU5F3; ABCG1; ATF4; CENPA; BCL2A1; H2AFVA |
| structural constituent of cytoskeleton | TUBB; DMD; TUBE1; CCDC6; KRT15; NGS; EPB41L4B; SORBS2; MAPT; TUBGCP5 |
NEFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFL here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFL.
APP; PPP1R18; TERF1; MTMR2; tax; TNF; YWHAG; SCHIP1; PHLPP1; VIM; RAN; CHD3
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