NEK7
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Official Full Name
NIMA (never in mitosis gene a)-related kinase 7
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Overview
NEK7 [NIMA(never in mitosis gene a)-related kinase 7] is a member of the NIMA-related serine/threonine kinase family. NEK7 has been shown localize to spindle poles and to be required for mitotic spindle formation and cytokinesis. -
Synonyms
NEK7; NIMA (never in mitosis gene a)-related kinase 7; serine/threonine-protein kinase Nek7; nimA-related protein kinase 7; never in mitosis A-related kinase 7;
- Recombinant Proteins
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- Myc
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- Myc|DDK
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- Involved Pathway
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- Interacting Protein
- NEK7 Related Articles
NEK7 involved in several pathways and played different roles in them. We selected most pathways NEK7 participated on our site, such as Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of NIMA Kinases NEK9, NEK6, NEK7 | NEK6;NEK9;NEK7 |
Cell Cycle | TTK;HUS1;CCNE2;ARPP19A;GINS4;OIP5;SET;TERF2IP;CNEP1R1 |
Cell Cycle, Mitotic | NINL;CDK11A;HIST3H2BB;PCM1;TUBGCP2;HIST2H3C;NDEL1A;TSGA14;ZW10 |
M Phase | SGOL2;INCENP;NSL1;CNEP1R1;NCAPG;CTDNEP1;PDS5A;AHCTF1;KIF2A |
Mitotic Prophase | CTDNEP1;NCAPD3;NEK7;CNEP1R1;GORASP2;DULLARD;CTDNEP1B;NEK6;ARPP19 |
Nuclear Envelope Breakdown | CTDNEP1A;CTDNEP1;DULLARD;NEK7;CNEP1R1;TMEM188;CTDNEP1B;NEK6;NEK9 |
Nuclear Pore Complex (NPC) Disassembly | NEK7;NEK9;NEK6 |
NEK7 has several biochemical functions, for example, ATP binding, metal ion binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK7 itself. We selected most functions NEK7 had, and list some proteins which have the same functions with NEK7. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | PRKCA;AK7A;DCK;ACVR1L;DDX17;TSSK1;SKIV2L;EK1;PRKACBB |
metal ion binding | NRP1A;GDPD4;SCRT1;MYSM1;ZNF526;ATP11A;DMRT3A;RUFY2;PDE10A |
protein serine/threonine kinase activity | TTBK1;CSNK1A1;NEK9;Aatk;OXSR1B;MAP2K2A;CDK15;DCKL1B;GSK3A |
NEK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK7.
NEK9; NEK6; q7ard3_yerpe; Nek9
- Q&As
- Reviews
Q&As (5)
Ask a questionNEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.
NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.
NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.
NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.
NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.
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