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NEK7

  • Official Full Name

    NIMA (never in mitosis gene a)-related kinase 7

  • Overview

    NEK7 [NIMA(never in mitosis gene a)-related kinase 7] is a member of the NIMA-related serine/threonine kinase family. NEK7 has been shown localize to spindle poles and to be required for mitotic spindle formation and cytokinesis.
  • Synonyms

    NEK7; NIMA (never in mitosis gene a)-related kinase 7; serine/threonine-protein kinase Nek7; nimA-related protein kinase 7; never in mitosis A-related kinase 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEK7-174H Active Recombinant Human NEK7(2-end) Protein, N-His-tagged Sf21 His 2-end
Human NEK7-348H Recombinant Human NIMA-related kinase 7, His-tagged E.coli His
Human NEK7-661H Recombinant Human NEK7, Active E.coli N/A
Human NEK7-28259TH Recombinant Human NEK7 N/A
Human NEK7-371H Recombinant Human NEK7, GST-tagged, Active Sf9 Insect Cell GST
Human NEK7-761H Recombinant Human NEK7, His & GST tagged Insect Cell His/GST
Human NEK7-816H Recombinant Human NEK7 Mammalian Cell His
Human NEK7-654HCL Recombinant Human NEK7 cell lysate Insect Cell N/A
Human NEK7-1323H Recombinant Human NEK7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NEK7-588H Recombinant Human NEK7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NEK7-3611H Recombinant Human NEK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NEK7-7945HF Active Recombinant Full Length Human NEK7 Protein, GST-tagged Insect (sf21) GST 1-302
Human NEK7-3611H-B Recombinant Human NEK7 Protein Pre-coupled Magnetic Beads HEK293
Mouse NEK7-10577M Recombinant Mouse NEK7 Protein Mammalian Cell His
Mouse Nek7-4369M Recombinant Mouse Nek7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NEK7-6011M-B Recombinant Mouse NEK7 Protein Pre-coupled Magnetic Beads HEK293
Mouse NEK7-6011M Recombinant Mouse NEK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NEK7-3955R Recombinant Rat NEK7 Protein Mammalian Cell His
Rat NEK7-3613R-B Recombinant Rat NEK7 Protein Pre-coupled Magnetic Beads HEK293
Rat NEK7-3613R Recombinant Rat NEK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NEK7-2999R Recombinant Rhesus monkey NEK7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NEK7-2818R-B Recombinant Rhesus Macaque NEK7 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NEK7-2818R Recombinant Rhesus Macaque NEK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NEK7-1043Z Recombinant Zebrafish NEK7 Mammalian Cell His
Chicken NEK7-2922C Recombinant Chicken NEK7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEK7 Related Articles

NEK7 involved in several pathways and played different roles in them. We selected most pathways NEK7 participated on our site, such as Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of NIMA Kinases NEK9, NEK6, NEK7NEK6;NEK9;NEK7
Cell CycleTTK;HUS1;CCNE2;ARPP19A;GINS4;OIP5;SET;TERF2IP;CNEP1R1
Cell Cycle, MitoticNINL;CDK11A;HIST3H2BB;PCM1;TUBGCP2;HIST2H3C;NDEL1A;TSGA14;ZW10
M PhaseSGOL2;INCENP;NSL1;CNEP1R1;NCAPG;CTDNEP1;PDS5A;AHCTF1;KIF2A
Mitotic ProphaseCTDNEP1;NCAPD3;NEK7;CNEP1R1;GORASP2;DULLARD;CTDNEP1B;NEK6;ARPP19
Nuclear Envelope BreakdownCTDNEP1A;CTDNEP1;DULLARD;NEK7;CNEP1R1;TMEM188;CTDNEP1B;NEK6;NEK9
Nuclear Pore Complex (NPC) DisassemblyNEK7;NEK9;NEK6

NEK7 has several biochemical functions, for example, ATP binding, metal ion binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK7 itself. We selected most functions NEK7 had, and list some proteins which have the same functions with NEK7. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKCA;AK7A;DCK;ACVR1L;DDX17;TSSK1;SKIV2L;EK1;PRKACBB
metal ion bindingNRP1A;GDPD4;SCRT1;MYSM1;ZNF526;ATP11A;DMRT3A;RUFY2;PDE10A
protein serine/threonine kinase activityTTBK1;CSNK1A1;NEK9;Aatk;OXSR1B;MAP2K2A;CDK15;DCKL1B;GSK3A

NEK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK7.

NEK9; NEK6; q7ard3_yerpe; Nek9

Wang, R; Song, Y; et al. The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival. CLINICAL & TRANSLATIONAL ONCOLOGY 15:626-632(2013).
Hayward, DG; Newbatt, Y; et al. Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors of the Cell Cycle-Regulated Nek2 Kinase. JOURNAL OF BIOMOLECULAR SCREENING 15:918-927(2010).
O'Regan, L; Fry, AM; et al. The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis. MOLECULAR AND CELLULAR BIOLOGY 29:3975-3990(2009).
Belham, C; Roig, J; et al. A mitotic cascade of NIMA family kinases - Nercc1/Nek9 activates the Nek6 and Nek7 kinases. JOURNAL OF BIOLOGICAL CHEMISTRY 278:34897-34909(2003).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can you elaborate on the specific functions of NEK7 in mitosis and its contributions to spindle assembly and chromosome segregation? 04/30/2022

NEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.

In neurological disorders, what evidence links NEK7 to disease pathology, and what cellular processes in the nervous system involve NEK7 activity? 11/09/2021

NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.

In cancer research, what evidence supports the involvement of NEK7 in tumorigenesis, and are there potential therapeutic targets associated with NEK7 dysregulation? 10/08/2020

NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.

How is NEK7 expression regulated, and what are the consequences of dysregulated NEK7 in cellular homeostasis and disease states? 06/19/2019

NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.

How does NEK7 participate in the innate immune response, particularly in the activation of the NLRP3 inflammasome, and what are the implications for inflammatory diseases? 05/02/2018

NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.

Customer Reviews (3)

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Reviews
08/17/2021

    Great service, exceptional product quality

    02/13/2020

      Our lab swears by this protein. Fast shipping is a definite bonus.

      11/01/2019

        Superb quality, accompanied by excellent service.

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