Recombinant Human NEK7 protein(1-302aa), His-SUMO-tagged

• Cat.No.: NEK7-6161H
• Product Overview: Recombinant Human NEK7 protein(Q8TDX7)(1-302aa), fused with N-terminal His and SUMO tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: N-His-SUMO
• Protein length: 1-302aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 47.5 kDa
• AASequence: MDEQSQGMQGPPVPQFQPQKALRPD MGYNTLANFRIEKKIGRGQFSEVYR AACLLDGVPVALKKVQIFDLMDAKA RADCIKEIDLLKQLNHPNVIKYYAS FIEDNELNIVLELADAGDLSRMIKH FKKQKRLIPERTVWKYFVQLCSALE HMHSRRVMHRDIKPANVFITATGVV KLGDLGLGRFFSSKTTAAHSLVGTP YYMSPERIHENGYNFKSDIWSLGCL LYEMAALQSPFYGDKMNLYSLCKKI EQCDYPPLPSDHYSEELRQLVNMCI NPDPEKRPDVTYVYDVAKRMHACTA SS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: NEK7 NIMA (never in mitosis gene a)-related kinase 7 [ Homo sapiens ]
• Official Symbol: NEK7
• Synonyms: NEK7; NIMA (never in mitosis gene a)-related kinase 7; serine/threonine-protein kinase Nek7; nimA-related protein kinase 7; never in mitosis A-related kinase 7
• Gene ID: 140609
• mRNA Refseq: NM_133494
• Protein Refseq: NP_598001
• MIM: 606848
• UniProt ID: Q8TDX7

Reviews

08/17/2021

Great service, exceptional product quality

02/13/2020

Our lab swears by this protein. Fast shipping is a definite bonus.

11/01/2019

Superb quality, accompanied by excellent service.

Q&As

Can you elaborate on the specific functions of NEK7 in mitosis and its contributions to spindle assembly and chromosome segregation?

NEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.

In neurological disorders, what evidence links NEK7 to disease pathology, and what cellular processes in the nervous system involve NEK7 activity?

NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.

In cancer research, what evidence supports the involvement of NEK7 in tumorigenesis, and are there potential therapeutic targets associated with NEK7 dysregulation?

NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.

How is NEK7 expression regulated, and what are the consequences of dysregulated NEK7 in cellular homeostasis and disease states?

NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.

How does NEK7 participate in the innate immune response, particularly in the activation of the NLRP3 inflammasome, and what are the implications for inflammatory diseases?

NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.