NKX6-1
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Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | MAFA,IAPP,PAX4,INS,PDX1,HNF1B,ONECUT1,FOXA2,HNF4G,NKX6 |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ARNT2,TTC4,ZNF134,GTF3A,ALX1,SMAD5,RORCB,NR2F1B,MLXIPL,ARNTL1B |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | SREBF2,ATF7,SPI1,NKX6-2,MXD1,NFATC4,PROX1A,OVOL1,REST,NR2E1 |
| sequence-specific DNA binding | FOXP1B,IRX6A,POU5F1,PBX2,SOX7,NKX3.3,ATF6B,ZNF238,CREB5,FOXO4 |
| chromatin binding | GM606,POU4F2,ZGLP1,PRKCB,HINFP,DNMT3A,POLR2B,STAT5B,EP300,MB21D2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | EBF1,EN1,MITFA,NEUROG3,JUND,ZNF148,TCF4,ELF1,ELK1,CTCFL |
| DNA binding | HMGB3B,FOXD1,THAP10,ZFP41,ZFPM2,TBX22,TNFAIP3,ZFP28,ISL2,FOXA |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
