NKX6-1
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Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Baculovirus
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
- Non
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | FOXA2,FOXA3,BHLHA15,RFX6,PAX6,INS2,ONECUT1,INS1,NEUROD1,HNF1A |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | FOXD4L1,ZNF215,HMX3,NCOR1,MEOX1,HOXA3A,SIX1A,NR6A1A,PPARAA,ATF4 |
| DNA binding | TAF13,ZNF23,THAP4,ZSCAN18,CLOCK,UBP1,TOP1,ZBED6,PBX1,ZFP580 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFIL3,NKX6-2,BCL11AB,BATF3,NFIL3-2,PYDC3,SPI1,CC2D1B,ZFP746,CC2D1A |
| transcription factor activity, sequence-specific DNA binding | ASCL1B,TFE3,RREB1,SCAND3,AHR1A,GLI4,TEF,ZFP11,POU2F1,MYNN |
| chromatin binding | ATAD2B,PRMT6,SVEP1,MECP2,SIN3B,MED1,CHAF1B,CCDC111,PRIMPOL,HMGB3B |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | GCM1,FOXL2,TCF3,SIX4,NFIA,ESR1,RFX3,ISL1,BSX,NRF1 |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
