nkx6-1
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  • Official Full Name
  • NK6 homeobox 1
  • Background
  • In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
  • Synonyms
Cat.#:NKX6-1-567HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NKX6-1 Protein, His/GST-tagged
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Cat.#:NKX6-1-5905HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NKX6-1 Protein, GST-tagged
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Cat.#:NKX6-1-600HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NKX6-1
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Cat.#:NKX6-1-10704MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NKX6-1 Protein
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Cat.#:NKX6-1-3994RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NKX6-1 Protein
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Involved Pathway

NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Maturity onset diabetes of the young
HNF1A; HNF1B; INS; IAPP; MNX1; HHEX; FOXA2; PDX1; PKLR; HES1

Protein Function

NKX6-1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein FOXQ1A; PAX2; HMGB1B; THOC1; NUCB1; ZNF784; PPARA; CCDC79; ASCL1B; HOXB4A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FOSL2; E2F4; TFE3; MAFB; ZNF486; KLF5; ZNF257; SIX5; FOXJ1; GATA1
Function chromatin binding
Related Protein FANCM; RBPJL; NCOA1; MED12; KLHDC3; HDGFRP2; CDK9; NR5A5; SUPT5H; GATA3
Function sequence-specific DNA binding
Related Protein HOXB4A; TBX3; MYOG; RXRBB; ATF5A; RORB; PAX6A; ARX; MAFGA; VRTN
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF215; FOXP2; LBX1; POU2F1B; ZNF234; NR5A2; ZFP322A; ZNF613; FOXI3B; ZSCAN23
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein TFAP2C; ZFP536; SNAI1; KLF17; ESRRA; TBX3; HSF1; GCFC2; CC2D1A; HELT

NKX6-1 Related Articles

Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).