NKX6-1
-
Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Baculovirus
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
- Non
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | RFX6,HNF4G,INS1,HES1,PAX4,FOXA3,PKLR,HNF1A,MAFA,PAX6 |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TLX1,NEUROD1,JDP2,NKX2,ELF3,ZNF257,PRDM1,SFPI1,PAXBP1,TFE3A |
| DNA binding | HOXD12A,MSGN1,NR5A2,EBF3A,MECP2,PHTF2,TBPL2,DBX1B,ZFP74,HOXD4A |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ATF3,CC2D1A,NFIL3-4,FOXO1,KCNIP3,NR2C1,SNAI1,OVOL1,NKX6-2,AEBP2 |
| chromatin binding | BRD2,PRKAA1,NKX6,CCNT1,CHAF1B,ATAD2,LRWD1,RERE,ING2,BAHCC1 |
| transcription factor activity, sequence-specific DNA binding | GLI4,SUPT6H,NEUROD1,HEYL,ZBTB11,FOXQ1A,CBL,MYCA,ZNF354B,CSDA |
| sequence-specific DNA binding | ZNF394,MAFBA,HOXB2,ZFP536,DMRT3A,TBX5A,HOXB4,LHX1B,FOXD1,NR5A2 |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
Resources
Related Services
Related Products
References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
