NKX6-1
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Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Baculovirus
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
- Non
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | RFX6,HNF4G,FOXA3,PAX6,HNF1B,ONECUT1,PAX4,HHEX,INS2,PDX1 |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | PAX2A,THAP6,OLIG2,SRY,BEND5,MTF1,RBFOX3,HIF1AL,TTC5,SOX2 |
| sequence-specific DNA binding | ERF,FOXN3,ELF2A,DBX1,TFAP2B,FOXN1,GATA5,UNCX4.1,HLF,MEOX2 |
| transcription factor activity, sequence-specific DNA binding | MYCB,DLX3,BACH2,ZFP2,RXRAA,ZNF621,ZSCAN4,NKX2-5,ZIM3,NR6A1B |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZBTB20,NFATC4,TBX3,GZF1,HES1,PPARA,YY1,REST,PROX2,MXD1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | BSX,PDX1,FOXJ2,MED8,FOXA2,TFAP2E,ELF1,SOX10,MTF1,NRF1 |
| chromatin binding | PRIMPOL,RUNX2,PLAC8,HDGF2,BAHCC1,HCFC1,KIAA0101,ARID5A,POLR2B,EZH2 |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
