NKX6-1
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Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Baculovirus
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
- Non
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | FOXA3,HNF4G,INS2,HES1,PDX1,NEUROG3,INS1,HNF4A,PAX6,INS |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | NR5A1B,SMAD2,NANOG,MAP3K7,MTF1,POU3F1,ZNF16,SPI1B,GRHL3,POU1F1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CTCF,SMAD6,RFX3,RFX5,NRF1,ZNF395,FOXA2,CREB1,SP1,GATA1 |
| DNA binding | ZBTB2,FOXI3B,LBX1,FOXE1,TFAP4,CREB3,MNX2A,ZNF324,CXXC1B,ZNF573 |
| sequence-specific DNA binding | HOXB2A,NKX6.2,NKX2.4B,NKX2.2A,DBX1,POU4F2,PRRX1A,ATF4B1,MEF2A,FOXQ1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | CUX2,ZFP536,HELT,NKX6-2,CREBBP,AEBP2,NACC2,HINFP,ATF3,ATF7 |
| chromatin binding | TRIM37,TADA2B,SOX10,FABP1,TCF3,CIC,POU5F3,SUPT5H,FOXO1,TOP2B |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
