NOD1

Official Full Name

nucleotide-binding oligomerization domain containing 1
Overview

Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain (C
Synonyms

NOD1; nucleotide-binding oligomerization domain containing 1; CARD4, caspase recruitment domain family, member 4; nucleotide-binding oligomerization domain-containing protein 1; CLR7.1; NLR family; CARD domain containing 1; NLRC1; nucleotide binding olig;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NOD1-1318H	Recombinant Human NOD1 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	NOD1-3772HCL	Recombinant Human NOD1 293 Cell Lysate	HEK293	Non		Inquiry
Human	NOD1-1769H	Recombinant Human NOD1 protein, His & T7-tagged	E.coli	His&T7	Ala612~Asp826	Inquiry
Human	NOD1-3895H	Recombinant Human NOD1 Protein (Ala612-Asp826), N-His tagged	E.coli	His	Ala612-Asp826	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

NOD1 involved in several pathways and played different roles in them. We selected most pathways NOD1 participated on our site, such as Activated TLR4 signalling, Cytokine Signaling in Immune system, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activated TLR4 signalling	AGER;S100A12;UBE2V1;NOD1;DUSP7;CREB1B;RIPK3;SIGIRR;DUSP4
Cytokine Signaling in Immune system	SPRED1;SPTA1;NUPL2;DUSP10;SPRED3;GBP4;TRIM38;NRG2A;KBTBD7
Epithelial cell signaling in Helicobacter pylori infection	ATP6V0B;ATP6V1A;ATP6V1D;MAP2K4;ATP6V1H;ATP6V0D2;ATP6V1G2;F11R;ATP6V1B1
Immune System	HERC5;RCA2.1;TREX1;Siglece;TRIM3;DEFB129;EIF4G2;CD207;IFIT8
Innate Immune System	ABI2;DEFB103A;ART1;NLRP4C;CHST13;PELI2;POLR3H;CRP;DEFB129
Interleukin-1 signaling	IL1RN;IRAK3;TNIP2;PELI1;PELI2;PELI3;NOD1
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
MAP kinase activation in TLR cascade	DUSP3;NOD1;TNIP2;DUSP3B

NOD1 has several biochemical functions, for example, ATP binding, CARD domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by NOD1 itself. We selected most functions NOD1 had, and list some proteins which have the same functions with NOD1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MLH3;ABL2;CSNK1G3;PRPS1L1;XRCC2;DNAJA3B;MYO1H;CDK18;NPR1
CARD domain binding	CARD14;RIPK2;CARD11;CARD9;MAVS;NOD1;C9orf89
cysteine-type endopeptidase activator activity involved in apoptotic process	CARD8;BCL2L13;NOD1;PYCARD;CTSH;GNB2L1;MAPK9;APAF1;NLRP1
identical protein binding	STK10;ERBB3;MAP3K11;CLDN7;PPPDE2;CCL4;EWSR1;UBE2G2;PFKM
peptidoglycan binding	NOD1;TREM2;PGLYRP3;NLRP3;TLR2;PGLYRP2;PGLYRP4;PGLYRP1;RNASE7
protein binding	POGZ;WDFY3;PROM1;GLDN;DYNLRB1;AGT;TEX19.1;SHC1;BCL2L2
protein homodimerization activity	UGT1A7;SYNDIG1;RPL7;NFKB1;C9orf142;DCK;TPD52L2;XCL1;NRBP1

NOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOD1.

RIPK2; HSP90AA1; sspH2; a8k1f4_human; b3ktt5_human; b4dyc6_human; HSPA1A; CASP9; PSMD2; FKBP5; PTGES3; CDC37; Usp19

Research Area

Post-translational Modification of NFkB/IkB

NOD-like Receptors and the Inflammasome

Adaptor Proteins

Adaptor Proteins in the Akt Pathway

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).

Xie, JS; Belosevic, M; et al. Functional characterization of receptor-interacting serine/threonine kinase 2 (RIP2) of the goldfish (Carassius auratus L.). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:76-85(2015).