NOD1
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Official Full Name
nucleotide-binding oligomerization domain containing 1 -
Overview
Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain (C -
Synonyms
NOD1;nucleotide-binding oligomerization domain containing 1;CARD4, caspase recruitment domain family, member 4;nucleotide-binding oligomerization domain-containing protein 1;CLR7.1;NLR family;CARD domain containing 1;NLRC1;nucleotide binding olig
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NOD1-1318H | Recombinant Human NOD1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| NOD1-3772HCL | Recombinant Human NOD1 293 Cell Lysate | HEK293 | Human | Non |
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| NOD1-1769H | Recombinant Human NOD1 protein, His & T7-tagged | E.coli | Human | His&T7 | Ala612~Asp826 |
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| NOD1-3895H | Recombinant Human NOD1 Protein (Ala612-Asp826), N-His tagged | E.coli | Human | His | Ala612-Asp826 |
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Involved Pathway
NOD1 involved in several pathways and played different roles in them. We selected most pathways NOD1 participated on our site, such as Activated TLR4 signalling,Cytokine Signaling in Immune system,Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | MAP2K4,ATP6V1A,ATP6V1G1,ATP6V1G2,GIT1,ATP6V0E1,MET,CDC42,IKBKB,NFKBIA |
| Interleukin-1 signaling | TNIP2,IL1RN,PELI2,PELI1,PELI3,IRAK3 |
| Immune System | CTSB,PANX1,DEFB121,CTSE,CASP2,HLA-DQB2,GBP5,TRIM5,SIGLEC11,IFI6 |
| Innate Immune System | S100A12,IRAK3,TXNIP,DUSP3,CR1,HERC5,DDX41,FAM49BA,PPAPDC1A,CLEC4D |
| Cytokine Signaling in Immune system | CISH,EIF4G2,SPTB,SPNA2,WDR83,KPNA4,IFI6,IRAK3,TRIM17,IFIT3 |
| MAP kinase activation in TLR cascade | DUSP3B,DUSP3,TNIP2 |
| Activated TLR4 signalling | DUSP7,RIPK3,AGER,ALCAMB,TANK,IRAK3,TIRAP,CHST13,S100A12,SIGIRR |
Protein Function
NOD1 has several biochemical functions, for example, ATP binding,CARD domain binding,cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by NOD1 itself. We selected most functions NOD1 had, and list some proteins which have the same functions with NOD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | NKX2,UPK1A,BLOC1S6,DAXX,DMRTB1,NADK2,CLN6,MFF,TCF3B,ADH5 |
| protein binding | NVL,CHMP1A,PIP,DCAF7,CALML3,VCPKMT,NCKAP1L,CRYBA4,FIBPB,PAPOLA |
| CARD domain binding | MAVS,RIPK2,CARD14,CARD9,C9orf89,CARD11 |
| peptidoglycan binding | PGLYRP4,PGLYRP2,RNASE7,PGLYRP1,NLRP3,TREM2,PGLYRP3,TLR2 |
| identical protein binding | DIAPH1,TNN,DRG1,ROBO2,CCL4,ADIPOQ,ACY3,PFKL,TGFB3,ZDHHC17 |
| ATP binding | UBE2D2,STK32C,PRPS1L1,ADCY6,MAPK14,CAMK1GA,CSF1RA,DYNC1LI2,MASTL,SWAP70 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | APAF1,CTSC,CARD8,CTSH,CASP1,BAD,MAPK9,RPS27L,NLRP12,BCL2L13 |
Interacting Protein
NOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOD1.
RIPK2;HSP90AA1;sspH2;a8k1f4_human;b3ktt5_human;b4dyc6_human;HSPA1A;CASP9;PSMD2;FKBP5;PTGES3;CDC37;Usp19
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References
- Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
- Xie, JS; Belosevic, M; et al. Functional characterization of receptor-interacting serine/threonine kinase 2 (RIP2) of the goldfish (Carassius auratus L.). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:76-85(2015).
