WHSC1
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Official Full Name
Wolf-Hirschhorn syndrome candidate 1
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Overview
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. -
Synonyms
WHSC1; Wolf-Hirschhorn syndrome candidate 1; probable histone-lysine N-methyltransferase NSD2; MMSET; NSD2; FLJ23286; IL5 promoter REII region binding protein; KIAA1090; MGC176638; MMSET type II; Multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain protein; Multiple myeloma SET domain-containing protein; NSD 2; NSD2_HUMAN; Nuclear SET domain-containing protein 2; Protein trithorax-5; REIIBP; Trithorax/ash1 related protein 5; TRX5; TRX5 protein; WHS; Wolf Hirschhorn syndrome candidate 1; Wolf Hirschhorn syndrome candidate 1 protein; Wolf-Hirschhorn syndrome candidate 1 protein; OTTHUMP00000159146; OTTHUMP00000220792; OTTHUMP00000220796; OTTHUMP00000220798; OTTHUMP00000220830; trithorax/ash1-related protein 5; IL5 promoter REII region-binding prote;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Flag
- Flag|His
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
WHSC1 involved in several pathways and played different roles in them. We selected most pathways WHSC1 participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with WHSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | HADHAB;SUV39H1B;GLT25D1;ASH1L;ALDH2.1;HADHAA;EHMT2;SETD8;SETD2 |
| Transcriptional misregulation in cancer | HMGA2;DEFA3;LMO2;RELA;SIN3A;ERG;HIST1H3C;PDGFA;NFKB1 |
WHSC1 has several biochemical functions, for example, chromatin binding, histone methyltransferase activity (H4-K20 specific), protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WHSC1 itself. We selected most functions WHSC1 had, and list some proteins which have the same functions with WHSC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | SMARCD3;GABPA;POU2F1;KLF14;GATA2A;TSHZ3;NSBP1;CNBPA;LRWD1 |
| histone methyltransferase activity (H4-K20 specific) | SUV420H2;WHSC1;SUV420H1;NSD1 |
| protein binding | RIPK4;ASPH;INHA;MAP2K7;MAP3K3;ACVRL1;USP14;STAT2;SCNN1B |
| sequence-specific DNA binding | ARGFX;JUNBA;MEOX2;POU5F3;MAFF;ZFP161;SALL4;NKX2.5;FOXA3 |
| zinc ion binding | PHF17;RNF145B;DNLZ;ZFAND4;FTR43;RNF169;AQPEP;ANKIB1A;CSRP1A |
WHSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WHSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WHSC1.
AR; MDM2; MNDA
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