OCRL

  • Official Full Name

    oculocerebrorenal syndrome of Lowe

  • Overview

    This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

  • Synonyms

    OCRL;oculocerebrorenal syndrome of Lowe;inositol polyphosphate 5-phosphatase OCRL-1;OCRL1;Lowe oculocerebrorenal syndrome protein;phosphatidylinositol polyphosphate 5-phosphatase;LOCR;NPHL2;INPP5F;OCRL-1

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • Flag
  • DDK
  • Myc

    Involved Pathway

    OCRL involved in several pathways and played different roles in them. We selected most pathways OCRL participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with OCRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism PI4KAA,MIOX,PLCB4,IPMK,ITPKC,TPI1B,IMPA1,PIP5K1AA,PIKFYVE,MINPP1B
    Phosphatidylinositol signaling system INPP5KA,CALM,PI4KA,IMPAD1,PIP5K1AB,INPP5B,CALM3B,PLCB1,ITPK1A,PIK3R1
    Metabolic pathways TPH1A,IPMK,PHOSPHO1,NADK,ALG1,MDH2,HSD17B10,TGDS,AKR1B8,PDXKB

    Protein Function

    OCRL has several biochemical functions, for example, GTPase activator activity,Rac GTPase binding,inositol phosphate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OCRL itself. We selected most functions OCRL had, and list some proteins which have the same functions with OCRL. You can find most of the proteins on our site.

    Function Related Protein
    inositol phosphate phosphatase activity CTDSPL2B,CTDSPL2A,SACM1L,NT5DC3,PTPRQ,TENC1,SACM1LB,PXYLP1,SACM1LA,SGPP2
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity INPP5B,EPM2A,INPP5E,PTPMT1,SYNJ2
    Rac GTPase binding FMNL1,CORO1C,RAB7A,ARFIP2,NCF2,SRGAP1,MAP3K11,RCC2,PAK7,ARHGEF2
    GTPase activator activity GRTP1A,AGFG1B,ARAP2,ARHGAP25,RASA1,MURC,WNT11,RGS12,ARHGAP29,NIPAL1
    protein binding LIPT2,NR2C2AP,PYCRL,TBC1D15,MYL12A,CTTNBP2NL,ARPM1,ROCK2,CORO2B,SNX2

    Interacting Protein

    OCRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OCRL here. Most of them are supplied by our site. Hope this information will be useful for your research of OCRL.

    RAB8A;RAB5A

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