| Description : |
This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
103.2 kDa |
| AA Sequence : |
MEPPLPVGAQPLATVEGMEMKGPLR EPCALTLAQRNGQYELIIQLHEKEQ HVQDIIPINSHFRCVQEAEETLLID IASNSGCKIRVQGDWIRERRFEIPD EEHCLKFLSAVLAAQKAQSQLLVPE QKDSSSWYQKLDTKDKPSVFSGLLG FEDNFSSMNLDKKINSQNQPTGIHR EPPPPPFSVNKMLPREKEASNKEQP KVTNTMRKLFVPNTQSGQREGLIKH ILAKREKEYVNIQTFRFFVGTWNVN GQSPDSGLEPWLNCDPNPPDIYCIG FQELDLSTEAFFYFESVKEQEWSMA VERGLHSKAKYKKVQLVRLVGMMLL IFARKDQCRYIRDIATETVGTGIMG KMGNKGGVAVRFVFHNTTFCIVNSH LAAHVEDFERRNQDYKDICARMSFV VPNQTLPQLNIMKHEVVIWLGDLNY RLGMPDANEVKSLINKKDLQRLLKF DQLNIQRTQKKAFVDFNEGEIKFIP TYKYDSKTDRWDSSGKCRVPAWCDR ILWRGTNVNQLNYRSHMELKTSDHK PVSALFHIGVKVVDERRYRKVFEDS VRIMDRMENDFLPSLELSRREFVFE NVKFRQLQKEKFQISNNGQVPCHFS FIPKLNDSQYCKPWLRAEPFEGYLE PNETVDISLDVYVSKDSVTILNSGE DKIEDILVLHLDRGKDYFLTISGNY LPSCFGTSLEALCRMKRPIREVPVT KLIDLEKSLLQMVPLDEGASERPLQ VPKEIWLLVDHLFKYACHQEDLFQT PGMQEELQQIIDCLDTSIPETIPGS NHSVAEALLIFLEALPEPVICYELY QRCLDSAYDPRICRQVISQLPRCHR NVFRYLMAFLRELLKFSEYNSVNAN MIATLFTSLLLRPPPNLMARQTPSD RQRAIQFLLGFLLGSEEDTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
