OGG1
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Official Full Name
8-oxoguanine DNA glycosylase
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Overview
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. -
Synonyms
OGG1; 8-oxoguanine DNA glycosylase; N-glycosylase/DNA lyase; 8 hydroxyguanine DNA glycosylase; HMMH; HOGG1; MUTM; OGG1 type 1d; OGG1 type 1e; OGG1 type 1g; OGG1 type 1h; OGH1; AP lyase; OGG1 type 1f; 8-hydroxyguanine DNA glycosylase; DNA-apurinic or apyri;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Yeast
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- OGG1 Related Articles
- OGG1 Related Research Area
OGG1 involved in several pathways and played different roles in them. We selected most pathways OGG1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with OGG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | HMGB1;OGG1;POLD2;HMGB1A;NEIL1;POLL;nth;APEX2;SMUG1 |
OGG1 has several biochemical functions, for example, 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity, DNA N-glycosylase activity, damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OGG1 itself. We selected most functions OGG1 had, and list some proteins which have the same functions with OGG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | |
| DNA N-glycosylase activity | TDG;NTHL1;NEIL3;NEIL1;OGG1;SMUG1 |
| damaged DNA binding | NEIL1;RUVBL2;TRP53;TDG;FANCG;RAD23AB;BRCA1;DCLRE1A;H2AFX |
| endonuclease activity | SMG6;EAR5;PELO;OGG1;RNASE6;CL2;ANG4;RNASE4;APEX1 |
| oxidized purine DNA binding | OGG1;RPS3 |
| oxidized purine nucleobase lesion DNA N-glycosylase activity | OGG1;RPS3 |
| protein binding | BBS12;ZNF614;ISL1;PXN;PIK3CG;LARP7;CXCL11;ANGPT2;PPIAL4A |
OGG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OGG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OGG1.
XPC; 31652240; Ogg1; SNRPF; CHGB; Hspd1
- Q&As
- Reviews
Q&As (5)
Ask a questionOGG1 protein is normally linked to HIS.
OGG1 is involved in research on diseases such as cataracts and colon cancer.
OGG1 is a DNA repair enzyme involved in base repair excision process.
OGG1 interacts with Smad7.
OGG1 knockdown exacerbates alveolar developmental block caused by hyperoxic stress.
Customer Reviews (3)
Write a reviewThe OGG1 proteins purchased from your company is suitable for ELISA.
The company provides one-stop service, from the purchase of products to the completion of experiments in one go.
The staff had a good attitude, actively communicated with me and solved many technical problems.
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