Recombinant Human OGG1 Protein (Met1-Gly345), C-His tagged, Animal-free, Carrier-free

• Cat.No.: OGG1-238H
• Product Overview: Recombinant Human OGG1 Protein (Met1-Gly345) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: 8-oxoguanine DNA glycosylase-1 (OGG1) is a major DNA glycosylase that plays a critical role in n base-excision repair (BER) of oxidative DNA damage to nuclear and mitochondrial DNA (mtDNA) to remove 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-OH-dG). OGG1 is a 38.8 kDa protein containing 52 amino acid it found in bacterial, archaeal and eukaryotic species. OGG1 in DNA causes G:C to T:A transversions and, therefore, it could be responsible for mutations that lead to carcinogenesis.
• Source: E. coli
• Species: Human
• Tag: C-His
• Form: Lyophilized
• Molecular Mass: The protein has a calculated MW of 39.61 kDa.
  The protein migrates as 40 kDa under reducing condition (SDS-PAGE analysis).
• Protein Length: Met1-Gly345
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: OGG1 8-oxoguanine DNA glycosylase [ Homo sapiens (human) ]
• Official Symbol: OGG1
• Synonyms: OGG1; 8-oxoguanine DNA glycosylase; N-glycosylase/DNA lyase; 8 hydroxyguanine DNA glycosylase; HMMH; HOGG1; MUTM; OGG1 type 1d; OGG1 type 1e; OGG1 type 1g; OGG1 type 1h; OGH1; AP lyase; OGG1 type 1f; 8-hydroxyguanine DNA glycosylase; DNA-apurinic or apyrimidinic site lyase
• Gene ID: 4968
• mRNA Refseq: NM_002542
• Protein Refseq: NP_002533
• MIM: 601982
• UniProt ID: O15527