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OSMR

  • Official Full Name

    oncostatin M receptor

  • Overview

    This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    OSMR; oncostatin M receptor; oncostatin-M-specific receptor subunit beta; OSMRB; MGC140467; MGC150626; MGC150627; MGC75127; Oncostatin M specific receptor subunit beta; Oncostatin M-specific receptor, beta; IL-31RB; IL-31R-beta; IL-31R subunit beta; IL-31 receptor subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit; PLCA1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OSMR-542H Active Recombinant Human OSMR Mammalian cells N/A Glu28-Ser739
Human OSMR-1759H Recombinant Human OSMR protein, His & T7-tagged E.coli His/T7 Gly513~Tyr760 (Accession # Q99650)
Human OSMR-2318H Recombinant Human OSMR protein, His-tagged HEK293 His Met1-Met740
Human OSMR-2520HCL Recombinant Human OSMR cell lysate Human Cell N/A
Human CAB11590RH Rabbit Monoclonal Antibody to Human Oncostatin M Receptor Rabbit N/A
Human OSMR-3753H Recombinant Human OSMR Protein (Glu28-Ser739), C-His tagged E.coli C-His Glu28-Ser739
Human OSMR-454H Recombinant Human OSMR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human OSMR-5863H Recombinant Human OSMR protein, His&Myc-tagged E.coli His&Myc 762-979aa
Human OSMR-1240H Recombinant Human OSMR protein, His-tagged HEK293 His Glu28-Ser739
Human OSMR-5289H Recombinant Human OSMR Protein (Glu28-Ser739), C-His tagged Mammalian cells C-His Glu28-Ser739
Human OSMR-4469H-B Recombinant Human OSMR Protein Pre-coupled Magnetic Beads HEK293
Human OSMR-4469H Recombinant Human OSMR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human OSMR-0599H Recombinant Human OSMR protein, His-tagged HEK293 His Glu28-Met740
Human OSMR-5290H Recombinant Human OSMR Protein (Met1-Met740), C-His tagged Mammalian cells C-His Met1-Met740
Human OSMR-5291H Recombinant Human OSMR Protein (Glu28-Glu342), N-His tagged E.coli N-His Glu28-Glu342
Mouse Osmr-1016M Active Recombinant Mouse Osmr Protein, Fc Chimera Mammalian cells Fc
Mouse Osmr-1760M Recombinant Mouse Osmr protein, His & GST-tagged E.coli His/GST Trp410~Gly652 (Accession # O70458)
Mouse Osmr-5187M Recombinant Mouse Osmr, His tagged Human Cell His
Mouse OSMR-1789MCL Recombinant Mouse OSMR cell lysate Human Cell N/A
Mouse Osmr-98M Recombinant Mouse Osmr Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Osmr-98M-B Recombinant Mouse Osmr Protein Pre-coupled Magnetic Beads HEK293
Rat Osmr-1761R Recombinant Rat Osmr protein, His & T7-tagged E.coli His/T7 His503~Gly749 (Accession # Q65Z14)
Rat OSMR-4209R Recombinant Rat OSMR Protein Mammalian Cell His
Rat OSMR-3871R-B Recombinant Rat OSMR Protein Pre-coupled Magnetic Beads HEK293
Rat OSMR-3871R Recombinant Rat OSMR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus OSMR-1297C Recombinant Cynomolgus OSMR protein, His-tagged HEK293 His Glu 28 - Ser 737
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • OSMR Related Articles
  • OSMR Related Research Area

OSMR involved in several pathways and played different roles in them. We selected most pathways OSMR participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSMR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCcl9;IL6;FIGF;Ifna11;LEP;IL1RAP;INHBA;IL12B;TNFRSF9A
PIK-Akt signaling pathwayIl6ra;MAP2K2;OSMR;ITGB5;COL6A5;PRLR;HSP90AA1;IFNA2;FGFR4
Jak-STAT signaling pathwaySTAM2;MTOR;IL11;IFNA7;FHL1B;IL3RA;LEPB;AKT2;EPO

OSMR has several biochemical functions, for example, growth factor binding, contributes_to oncostatin-M receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OSMR itself. We selected most functions OSMR had, and list some proteins which have the same functions with OSMR. You can find most of the proteins on our site.

Function Related Protein
growth factor bindingTEK;FLT4;FGFBP2;HTRA1B;REG3B;NRP1;ACVR2A;RPL37;LIFR
contributes_to oncostatin-M receptor activityOSMR;IL6ST;LIFR

OSMR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSMR here. Most of them are supplied by our site. Hope this information will be useful for your research of OSMR.

ERBB2; GAPDH; q5nfj2_fratt; BAG3; Bmpr1a

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).
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