• Official Full Name

    HumanIL-12/23 p40

  • Background

    Bioactive interleukin-12 p70 (IL-12p70) is a heterodimer composed of 2 subunits: p35 and p40. Although p35 is expressed in numerous cell types, p40 expression is more restricted and determines the ability of a given cell-type to produce bioactive IL-12. However, in the cells that are capable of producing both IL-12 subunits, it is the p35 subunit, produced in much lower amounts than p40, that plays the role of a limiting factor and determines the amount of bioactive IL-12p70 that is secreted. IL-12p70 heterodimer is a major Th1-driving cytokine. In contrast, p40 homodimer, secreted by antigen presenting cells (APCs) in the absence of p35 production, and to a lesser extent the p40 monomer, were shown to act as antagonists of mouse and human IL-12 receptors and to inhibit IL-12–dependent immune functions in vitro and in vivo.
  • Synonyms

    • Type:
    • Recombinant Proteins
    • Species :
    • Blood fluke
    • Human
    • Source :
    • CHO
    • E.coli
    • Yeast
    • Tag :
    • Fc|His
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Blood fluke p40-5595B Recombinant Blood fluke p40 protein, His-tagged Yeast His
    Blood fluke p40-3857B Recombinant Blood fluke p40 protein, His-tagged E.coli His
    Human p40-P1008H Recombinant Human IL-12/23 p40, Fc/His-tagged CHO Fc/His
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