|Official Full Name||HumanIL-12/23 p40|
|Background||Bioactive interleukin-12 p70 (IL-12p70) is a heterodimer composed of 2 subunits: p35 and p40. Although p35 is expressed in numerous cell types, p40 expression is more restricted and determines the ability of a given cell-type to produce bioactive IL-12. However, in the cells that are capable of producing both IL-12 subunits, it is the p35 subunit, produced in much lower amounts than p40, that plays the role of a limiting factor and determines the amount of bioactive IL-12p70 that is secreted. IL-12p70 heterodimer is a major Th1-driving cytokine. In contrast, p40 homodimer, secreted by antigen presenting cells (APCs) in the absence of p35 production, and to a lesser extent the p40 monomer, were shown to act as antagonists of mouse and human IL-12 receptors and to inhibit IL-12–dependent immune functions in vitro and in vivo.|
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p40 involved in several pathways and played different roles in them. We selected most pathways p40 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with p40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
p40 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by p40 itself. We selected most functions p40 had, and list some proteins which have the same functions with p40. You can find most of the proteins on our site.
p40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with p40 here. Most of them are supplied by our site. Hope this information will be useful for your research of p40.