p40
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Official Full Name
HumanIL-12/23 p40
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Background
Bioactive interleukin-12 p70 (IL-12p70) is a heterodimer composed of 2 subunits: p35 and p40. Although p35 is expressed in numerous cell types, p40 expression is more restricted and determines the ability of a given cell-type to produce bioactive IL-12. However, in the cells that are capable of producing both IL-12 subunits, it is the p35 subunit, produced in much lower amounts than p40, that plays the role of a limiting factor and determines the amount of bioactive IL-12p70 that is secreted. IL-12p70 heterodimer is a major Th1-driving cytokine. In contrast, p40 homodimer, secreted by antigen presenting cells (APCs) in the absence of p35 production, and to a lesser extent the p40 monomer, were shown to act as antagonists of mouse and human IL-12 receptors and to inhibit IL-12–dependent immune functions in vitro and in vivo. -
Synonyms
p40;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Blood fluke | p40-5595B | Recombinant Blood fluke p40 protein, His-tagged | Yeast | His |
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Blood fluke | p40-3857B | Recombinant Blood fluke p40 protein, His-tagged | E.coli | His |
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Human | p40-P1008H | Recombinant Human IL-12/23 p40, Fc/His-tagged | CHO | Fc/His |
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