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Recombinant Human IL-12/23 p40, Fc/His-tagged

Cat.No. : p40-P1008H
Product Overview : Recombinant Human IL-12/23 p40 fused with Fc fragment of Human IgG or His tag was expressed in CHO.
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Description : Bioactive interleukin-12 p70 (IL-12p70) is a heterodimer composed of 2 subunits: p35 and p40. Although p35 is expressed in numerous cell types, p40 expression ismore restricted and determines the ability of a given cell-type to produce bioactive IL-12. However, in the cells that are capable of producing both IL-12 subunits, it is the p35 subunit, produced in much lower amounts than p40, that plays the role of a limiting factor and determines the amount of bioactive IL-12 p70 that is secreted. IL-12 p70 heterodimer is a major Th1-driving cytokine. In contrast, p40 homodimer, secreted by antigen presenting cells (APCs) in the absence of p35 production, and to a lesser extent the p40 monomer, were shown to act as antagonists of mouse and human IL-12 receptors and to inhibit IL-12–dependent immune functions in vitro andin vivo.
Source : CHO
Species : Human
Tag : Fc/His
Predicted N Terminal : IWELKKDVYV
Form : Normally 20-50mM NaAC-HAC and 100-150 mM NaCl are added, pH 5.0-6.0.
Molecular Mass : Recombinant human p40 comprises 538 and 312 amino acids of p40-Fc and p40-6His, respectively. It is about 80 kDa and 52 kDa of p40-Fc and p40-6His under reducing conditions, respectively.
Endotoxin : <1.0EU per 10 mg protein as determined by the LAL method
Purity : >95% as determined by SDS-PAGE and HPLC
Stability : Samples are stable for up to six months from date of receipt at -20 centigrade and are stable for two months at 4 centigrade.
Storage : Store it under sterile conditions at -70 centigrade upon receiving. Recommend to pack the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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