Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway LASS2,FCER1G,MAPK3,ROCK1,PIK3CA,KRAS,PRKCG,TRAF2,PPP2CA,FYN
    Hepatitis C BRAF,CLDN9,RNASEL,PPARA,OAS1B,TP53,TRAF6,TRAF2,GSK3B,CLDN23
    Huntingtons disease NDUFB2,COX7B2,DNALC1,SP1,NDUFB6,ATP5F1,POLR2B,NDUFB1,ATP5H,MT-ATP6
    Basal cell carcinoma FZD7,DVL3,STK36,GSK3B,WNT2B,AXIN1,WNT9B,WNT6,FZD10,FZD8
    Central carbon metabolism in cancer SLC2A1,PFKL,PDK1,PKM,FGFR3,PGAM2,RET,MTOR,PDGFRB,LDHA
    Hepatitis B BAD,CASP10,RAF1,IFNA5,TNF,VDAC3,Casp3,TP53,IRF3,IFNA8
    Wnt signaling pathway WNT10B,FBXW11A,PPP3CCB,CUL1B,RHOAC,FZD5,PRKACAB,FZD9,WNT11R,WNT2B
    Neurotrophin signaling pathway PRKCD,NGF,MAP2K1,IRAK4,BDNF,RELA,GSK3B,MAPK3,TP73,MAPK12
    Bladder cancer MAPK3,CDK4,HRAS,TYMP,MMP1,MMP1A,EGF,E2F2,MMP9,RPS6KA5

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity HIST2H2BE,ATF4,HYPM,LIMK2,NPAS4,HIST1H2AI,SEPHS1,HER1,IKZF4,HIST1H3D
    transcription cofactor binding KLF4,FOXO3,CHD6
    DNA binding HER8A,MXD3,ASXL2,KLF12,SSRP1,RAG2,KAT6B,TFAP2C,ZFP354B,ZFP521
    RNA polymerase II transcription factor activity, sequence-specific DNA binding MED1,RUNX2,AHR2,TFDP2,ZNF446,SIM2,TFDP1B,SOX8A,FOXJ1B,FOXB1
    protease binding ADAMTSL4,TRIP4,FN1,FLOT2,CSTA,BCL2,MALT1,SERPINA5,POLG,SRI
    ATP binding DDX6,UBE2F,CDK9,MAP2K5,PANK1,EK1,KIF16B,TAOK2,TESK1,RYK
    protein self-association BCL10,CCDC88C,ZKSCAN17,SHANK3,ABCD3,CCL5,CNTN2,ZSWIM2,NKX3,NKX3-1
    chromatin binding HDGFRP2,MEN1,RELA,TCF7L1B,EP300,HDAC7,NOC2L,MSL1,FOSL2,SP3
    p53 binding CHD8,GATA1,STK11,ZNF385A,MAPKAPK5,TP53RK,TRIM29,TP73,KDM1A,BRD4

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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