Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis C CLDN22,STAT1,MAPK9,AKT1,MAPK12,TRADD,BAD,IKBKB,ARAF,OAS1A
    MAPK signaling pathway FGF20,MAP4K1,GNG12,MAPK10,NTRK1,PPM1B,DDIT3,CACNB4A,TNFRSF1A,RASGRF2B
    Chronic myeloid leukemia CDK6,MECOM,RELA,PIK3CD,CBLC,MAPK1,BRAF,PTPN11,IKBKG,AKT1
    p signaling pathway PTEN,SFN,BID,GADD45AA,RRM2,CCNG2,CYCSB,BIDA,CDK1,BAX
    Endometrial cancer AXIN1,PTEN,CCND1,MLH1,PIK3R5,BRAF,MAPK3,SOS1,APC2,NRAS
    Basal cell carcinoma HHIP,GSK3B,FZD1,GLI3,WNT9A,DVL1,FZD10,TCF7,BMP2,SUFU
    Melanoma FGF13,FGF22,PDGFD,MITF,PIK3CD,FGF8,PIK3CA,FGF7,FGF20,Fgf15
    Epstein-Barr virus infection HLA-DQA1,TRAF5,GTF2B,YWHAG,HLA-DPA1,MAPK13,SFPI1,HLA-DPB1,SHFM1,PSMC4
    Pathways in cancer FGF19,NTRK1,MTOR,LAMB2,LAMA3,GNAQ,LEF1,EGLN2,ITGAV,PTEN

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding POLR3B,C1GALT1,NADK,ACVR1B,ANKMY2A,SALL3B,ZGPAT,DNMT3B,ZFP35,CDKN1A
    copper ion binding TYRP1,SLC11A2,SOD1,SNCA,HAMP,LOXL5B,LOXL2A,P2RX4,TP53,HEPH
    receptor tyrosine kinase binding Flt3l,ANGPT2A,TOB1,ZFP259,ANGPT1,TP53,SHC4,SOCS5,HYAL2,FLT3LG
    RNA polymerase II core promoter sequence-specific DNA binding ZFPM1,FOS,SP3,ZNF277,NSD1,SPI1,EGR1,TCF7L2,SOX11,MTF1
    protein binding RPSA,LSM11,BCAM,PPP2R2C,PPIE,FLT4,FAM131B,TPD52L3,ECE2,SLC35A2
    protein heterodimerization activity NFE2L2A,BCL11A,BOKB,ATF2,ATF6,ADORA1,JAM3,TGFB2,SYCP3,SOX8
    transcription factor binding PPARGC1B,RB1,KAT8,ATF7,PBX1,FOXA3,PPARG,PYDC3,E2F2,DDIT3
    transcription cofactor binding KLF4,FOXO3,CHD6
    core promoter sequence-specific DNA binding MYOCD,CRY1,ZNF750,PRMT5,GATA3,TOP1,SOHLH2,SP1,MTA1,ZFHX3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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