Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway RAC2,NLK1,PSEN1,WNT8B,PRKCA,MAPK10,WNT7A,SKP1,WNT4A,FOSL1
    PIK-Akt signaling pathway PDPK1,FGF17,IFNA6,NFKB1,VEGFA,IFNB1,GNG2,ITGA4,HSP90B1,CREB3L2
    HTLV-I infection AKT2,ANAPC11,PIK3CB,RANBP1,RANBP3,IL1R1,HLA-G,TCF3,PIK3R1,ELK1
    Prostate Cancer PDGFA,CCNE1,GRB2,INSRR,IKBKG,ACTL6B,MDM2,PTEN,PDGFRA,GSK3B
    Colorectal cancer Casp3,RAC1,MAPK1,CYCS,CASP9,BIRC5,AXIN2,AKT1,PIK3CG,TGFBR1
    Transcriptional misregulation in cancer HIST1H3H,EYA1,TAF15,FLI1,CCNA1,SIN3A,HDAC2,MPO,MMP3,HIST2H3C2
    Basal cell carcinoma WNT7B,WNT5B,FZD8,TCF7,Fzd4,Shh,TCF7L2,GLI1,GSK3B,WNT10B
    Herpes simplex infection CSNK2A2,Ifna15,PER1A,HLA-DOA,EIF2AK2,MHC2DEB,TAP1,HLA-B,EIF2AK3,FB06F03
    Huntingtons disease NDUFA13,NDUFS8,NDUFA1,NDUFC1,BDNF,NDUFS1,COX5A,HTT,POLR2L,NDUFB10

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding OAS1B,MYO3A,SMC1A,PIK3R4,TSSK3,CKMT1B,CKMT1A,STK32A,PTK2BB,GK5
    double-stranded DNA binding HNRNPDL,SMAD2,SAFB,CSDA,GTF2H4,RAD51D,RAD51C,HNRPDL,HLF,MTERF3
    DNA binding ZBTB24,ZIM2,HIST1H2AG,SMARCB1A,ZNF565,ZFP184,HIST1H2AA,ZNF317,SIX3B,ARNTL2
    RNA polymerase II transcription factor binding GATA2A,GFI1B,SMAD4,TBX3,DHX9,KDM1A,GATA5,GSK3B,TP53,KLF4
    protein C-terminus binding TJP2,PFKM,VIM,CTGF,PDZD11,PPP2CA,DGKZ,STIP1,SNX17,COIL
    transcription factor binding TBX5,E2F4,PPP1R13BA,UBA2,SIRT1,PIAS1,KCNA3,CEBPG,LMO4,NCOA2
    damaged DNA binding RAD1,POLK,HMGB2,TP53BP1,APTX,RAD23AA,TP73,HMGB1,RAD52,XRCC6
    transcription regulatory region DNA binding ZFP161,GLI1,CEBPA,ZFP335,XRCC5,DHX36,REST,Ar,ZNF174,IKZF1
    MDM2/MDM4 family protein binding CDKN2A,RFWD3,PPARA,CDK5RAP3,CAV1,PSME3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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