Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Central carbon metabolism in cancer GLS,C12orf5,AKT1,PDHB,PIK3CG,FGFR2,HK2,HK1,PDHA1,ERBB2
    Transcriptional misregulation in cancer RUNX1T1,HIST1H3G,FLI1,SUPT3H,RUNX1,HIST1H3A,FCGR1,PLAT,SSX2,MMP9
    Cell cycle CENPO,CEP290,CLIP1,MLF1IP,CEP152,DULLARD,PCM1,STIL,CCND3,YWHAQA
    HTLV-I infection TBP,PPP3CB,H2-Q10,MAPK8,ATM,XPO1,SLC25A31,WNT3,WNT2B,XBP1
    Neurotrophin signaling pathway MAPK10,TRAF6,CAMK2D,FOXO3,ARHGDIA,MAP3K5,AKT2,IRAK1,Fasl,CAMK2B
    Pathways in cancer MSH6,FGF16,LAMA4,HDAC1,CASP9,Casp3,PIK3CG,PLEKHG5,Fzd4,WNT10B
    Apoptosis CASP6,GZMF,IKBKG,CDKN2A,TNFRSF10A,IKBKB,PPP3R2,PANK1A,AKT2,PIK3CG
    Small cell lung cancer CCND1,ITGAV,ITGA2B,LAMA5,CKS2,MAX,PTK2,ITGA6,LAMC2,LAMA3
    Prostate Cancer INS2,FOXA1,CCNE1,ARID1A,PDGFRB,MAP4K1,PDGFD,PTEN,PDPK1,CREB3L1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding SERPINB1A,LOXL1,AOC1,LOXL3,HEPHL1,CP,GPC1,COMMD1,ATOX1,LOXL5A
    protein phosphatase binding ERBB2,DRD1A,VRK3,PPP6R1,LCK,KCNN4,PPP6R3,MET,PPP1R3G,PPARG
    RNA polymerase II core promoter sequence-specific DNA binding SOX8,FOS,GBX2,MAZ,RBPJ,MTF1,EGR1,RUVBL2,SOX3,MITF
    protein heterodimerization activity HIST1H3F,CXCL13,HIST1H2BI,UGT1A4,ITGB1,UBA2,SOS1,MAPK6,IRAK2,ITGA3
    protease binding CAST,INS1,THAP5,PYCARD,TNF,KIT,ITGB3,CD28,TIMP3,CCDC71L
    ATP binding PRPS1,UBE2D2,UBE2E3,MASTL,KLHL8,CSNK1DB,SWAP70,RFK,PLK5,ABCB4
    RNA polymerase II transcription factor binding GSC,TBX6,MEF2A,WWP2,MTA2,ZFPM2,ZFPM2A,TRPS1,SPOP,ID4
    MDM2/MDM4 family protein binding PSME3,PPARA,CDK5RAP3,RFWD3,CAV1,CDKN2A
    transcription factor binding ZEB1,CEBPG,NFATC2,SRY,PBX2,FOXA3,HEYL,PIAS1,MAPK1,EPN1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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