Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-small cell lung cancer FHIT,PRKCA,BRAF,MAP2K1,AKT2,NRAS,CCND1,SOS1,RASSF1,PIK3R5
    Central carbon metabolism in cancer NRAS,PIK3R3,NTRK1,PIK3CA,IDH1,MAPK1,MAP2K2,KIT,HK3,PDGFRB
    Bladder cancer CXCL8,CDH1,MAPK1,RAF1,CDK4,RASSF1,THBS1,MDM2,VEGFA,UPK3A
    Sphingolipid signaling pathway MAPK9,RAC3,PLD1,PLCB3,PPP2R2A,SPTLC3,TRADD,TP53,FCER1A,NSMAF
    Viral carcinogenesis KAT2A,ATP6V0D1,UBR4,CDC42,PIK3R3,LYN,RHOA,HIST1H2BL,MAPK1,PIK3CD
    Hepatitis C TNFRSF1A,RAF1,IRF7,PIK3CD,NFKB1,TRAF2,IFNA5,CLDN18,OSTN,PIK3R2
    MicroRNAs in cancer RASSF1,CYP24A1,SOS1,MARCKS,ZFPM2,PRKCG,MET,KRAS,RHOA,NOTCH3
    PIK-Akt signaling pathway SGK1,PTK2,SGK3,RPS6,IFNA5,TEK,PPP2R2B,Fasl,IFNB1,MAPK1
    Pathways in cancer WNT9A,LAMB2,WNT7B,GNG5,RXRG,FGF1,FGF20,ITGA2B,MLH1,AGTR1A

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding MDM2,EHMT1,BANP,ZFP346,TRP63,EP300,AXIN1,SMARCA4,MSX1,ZNF385B
    receptor tyrosine kinase binding FLT3LG,SHC4,ANGPT2A,ANGPT4,PTPN1,NRG1,PLCG1,PTPN2,LRP4,PIK3R2
    transcription factor activity, sequence-specific DNA binding TFDP1B,HOXB8B,MYT1LA,RARG,CITED1,GATAD2A,ETV5B,NR1I3,TCF4,SIM1
    enzyme binding APBA3,BCR,CDC20,CPSF1,SIRT3,ZNHIT6,SRC,PPARG,BCL10,RPA2
    protein phosphatase binding RPA3,AP3B1,TRAF3,CDH2,PIK3R2,PPARG,ERBB2,SNX3,FLT4,EGFR
    double-stranded DNA binding PNKP,KLF6,RAD51D,SP8B,ZNF638,NTHL1,HMGB2,MEN1,CTNNB1,HES2
    protein heterodimerization activity INHBA,TCF12,HIST1H3C,UGT1A9,HIST1H3H,BNIP3,NPAS4,BTBD11,HIST1H4L,GAD2
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GATA2B,MAFG,ATF1,NR1I3,REST,FOXF1,MAFBA,PAX9,CSRNP1,MAFBB
    protein self-association PROSAPIP1,EPB49,AGTR1A,CNTN2,DYRK1A,MDH2,DVL2,RYR2,ACHE,AXIN1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *