Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Central carbon metabolism in cancer FGFR1,PIK3R5,SLC7A5,FLT3,AKT1,PIK3CG,SLC2A2,RET,IDH1,HIF1A
    Transcriptional misregulation in cancer TGFBR2,PLAT,ATM,CCNA1,NTRK1,MEIS1,RUNX2,SSX2,H3F3C,ERG
    Endometrial cancer PIK3CB,AKT1,GSK3B,MAPK3,PIK3CA,TP53,PIK3CD,PIK3R3,MAPK1,CTNNA3
    Thyroid cancer RXRB,RXRG,NCOA4,TFG,RXRA,MAPK3,TP53,TPM3,NTRK1,NRAS
    Bladder cancer RASSF1,TP53,ARAF,HRAS,MMP2,MMP1,THBS1,DAPK1,MMP1A,VEGFA
    Chronic myeloid leukemia MECOM,PTPN11,KRAS,NRAS,CRKL,CBLC,PIK3CD,RELA,MAPK1,RAF1
    Proteoglycans in cancer MAP2K2,SDC1,PDPK1,MET,FZD1,PPP1CC,FZD3,PTCH1,RPS6,IGF1R
    Viral carcinogenesis PKM,HDAC10,HIST1H2BM,HIST1H4D,HIST1H2BA,KAT2B,SRC,ACTN2,GTF2E1,TRADD
    Amyotrophic lateral sclerosis (ALS) TNFRSF1A,GRIN1,GRIN2B,PPP3CB,DAXX,Casp3,GRIN2D,BAD,GRIA2,NEFH

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein self-association ZSWIM2,ABCD3,SVIP,TP53,SLC9A3R1,AGTR1A,TRIM32,S100A7A,TMEM190,ZKSCAN17
    RNA polymerase II transcription factor binding ID4,TBX20,CREBBP,CHST13,ZFPM1,DHX9,ANKRD1,SFPI1,GATA1A,NFATC1
    double-stranded DNA binding DDX58,CGGBP1,ERCC5,FBXO18,FEV,MTERFD1,MTERF,NTHL1,CTNNB1,NEIL3
    protein C-terminus binding YWHAQ,EP300,CITED1,NCF2,FBLN1,TBL1X,CACNA1B,HPCAL4,TFCP2,MYO1C
    metal ion binding EXOG,ZDHHC18B,CSRP1B,ZNF174,ZNF75A,ZMYND15,AMHR2,TRIM109,ZNF701,PPM1G
    p53 binding RFFL,RNF20,NTRK3,DUSP26,USP10,AAAS,SIRT1,PTTG1IP,TAF9,KDM1A
    ATP binding PEX1,MAP3K1,ABCB10,DYNC1H1,STK36,PRKACG,ABCA8,HSP90AA1.1,IQCA1,CAMK2B
    transcription cofactor binding CHD6,FOXO3,KLF4
    DNA binding HELZ2,PROX1B,ZFP276,HUWE1,FOXJ1B,ZC3H3,RPS15,UNCX,DMC1,RFX8

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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