Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid cancer CDH1,TPM3,TP53,KRAS,NTRK1,RXRB,PAX8,TCF7L2,RXRG,MAP2K1
    Viral carcinogenesis YWHAH,DLG1,NFKB1,ACTN3,ACTN2,VAC14,HLA-B,PIK3CG,HIST1H2BD,GTF2E2
    Endometrial cancer PIK3CG,MAPK1,FOXO3,TCF7L2,AKT2,BAD,CTNNA3,TP53,ARAF,GSK3B
    Glioma RAF1,Pdgfa&Pdgfb,MAP2K2,TP53,NRAS,PDGFA,SOS1,SHC1,PDGFRA,MTOR
    Non-small cell lung cancer EML4,PIK3CG,TGFA,GRB2,RASSF1,NRAS,RXRB,RAF1,CASP9,ARAF
    Colorectal cancer AKT2,BIRC5,MLH1,SMAD2,BAX,PIK3CB,RAC1,TCF7,AXIN1,Casp3
    Wnt signaling pathway WNT8A,PPP3CCB,MAPK8B,WNT8B,RAC1B,PLCB3,MAPK8,RAC1,CXXC4,WNT16
    Apoptosis PANK1A,BCL2L1,HMGB2,OCLN,BAD,GZMF,GAS2,HIST1H1D,RIPK1,IKBKG
    Measles CD3E; CD3D,IFNA14,TYK2,EIF2AK2,RELA,Fasl,NFKBIA,OAS1A,SH2D1A,IFNGR1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding TP53,LOXL3A,ABHD1,DBH,SCO2,RNF7,LOXL4,AOC3,LOXL1,LOXL5B
    sequence-specific DNA binding HOXA4A,HOXB13A,HOXB6B,NKX6-1,FOXO1,PGBD1,FOXF2,CREBZF,IKZF4,POU3F3
    RNA polymerase II transcription factor binding GFI1B,XBP1,TBX20,TP53,ZFPM2,ZGLP1,GATA3,PITX2,KLF4,GSC
    protein self-association CNTN2,PROSAPIP1,TMEM43,ZFP639,ZKSCAN17,TP53,SLC9A3R1,CBR2,CTSC,TRIM32
    protein heterodimerization activity ADD2,MCL1B,NR2C2,SMC1A,SUPT3H,PEF1,H2-AA,GRIN1,H2AFB1,ALX4
    ATP binding MAPK14B,PARS2,KIF16B,PYGL,P2RX4A,UBE2KB,MCM3L,DDX19A,PDK4,MAP4K1
    ubiquitin protein ligase binding TRIM37,CCT2,RRAGA,CASP8,FBXW7,HSPA8,KDM4A,HIF1A,CUL4B,UBE2G1A
    transcription factor binding TBP,GATA2,UBE2I,PRKDC,PPID,RBL1,SOX17,GATA6,NKX2-5,HHEX
    protein C-terminus binding ATF4,PQBP1,TFCP2,CDK7,MAPRE1,MID1IP1,HSPG2,EFHC1,VGLL2,NCL

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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