Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bladder cancer ERBB2,MMP9,MYC,HBEGF,TYMP,DAPK1,ARAF,CXCL8,RB1,MAP2K1
    Neurotrophin signaling pathway BDNF,MAP2K2,PIK3CB,FOXO3,NRAS,FASLG,HRAS,PSEN2,ZNF274,MAP2K1
    Cell cycle FZR1A,ORC5,OIP5,SET,NDEL1B,ARPP19A,CUL1A,RCC2,CENPW,RUVBL2
    p signaling pathway RPRM,RFWD2,PERP,STEAP3,BAXA,PTENA,PMAIP1,SIAH2L,RPRMA,CCND2A
    Non-small cell lung cancer RB1,RASSF1,ERBB2,PIK3CB,PRKCB,RXRG,PLCG1,PIK3R5,FOXO3,HRAS
    Pancreatic cancer MAP2K1,IKBKB,RAC2,TGFA,TGFB2,BRCA2,RAC1,BRAF,PLD1,RALGDS
    HTLV-I infection WNT3,IL2RB,TP53,MAP3K14,CD3G,HRAS,ATF3,BUB3,WNT4,SMAD4
    Wnt signaling pathway FBXW2,RAC3B,CAMK2B,MAPK9,WNT3A,TBL1XR1,NFATC2,PRKACAA,FZD1,NKD1
    Apoptosis TNFRSF10B,CTNNB1,AKT3A,BIRC2,IL3,MYC,PRKACG,CAPN1,IRAK3,PPP3R1B

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region DNA binding SFPQ,TFE3,BRCA1,ZFP335,BRD7,ZNF613,NKX2-1,IKZF1,TBP,NKX3
    RNA polymerase II transcription factor binding KDM1A,SPOP,TP53,GSK3B,ZFPM2,GATA3,GATA4,XBP1,MKX,ZFPM1
    ATP binding PEO1,UBE1Y1,NEK11,AK7,STK32A,FANCM,DDX46,UBE2M,DHX9,TARS2
    p53 binding STK11,TP53BP1,TP73,TRP63,TAF3,ZNF385A,SETD7,ZNF385D,TAF9,TRIM24
    protein phosphatase binding STAT6,PPP6R1,FGF19,PIK3R2,PIK3R1,TRAF3,ITPR1,PARD3,SKAP1,IRS2
    protein C-terminus binding VPS4B,PHB2,TBL1X,PPM1A,TNNI3K,DST,JAK2,VPS36,ERCC1,PICK1
    protein binding NGFRB,TNS1,ZSCAN12,TJP1,CNGA1,RDM1,F12,SLC6A20B,BBC3,EEA1
    damaged DNA binding RUVBL2,MGMT,XRCC1,DCLRE1A,BRCA1,PNKP,TRP63,RAD1,TRPC2,POLH
    MDM2/MDM4 family protein binding CAV1,PSME3,CDKN2A,CDK5RAP3,RFWD3,PPARA

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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