Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway PFKFB2,ITGB3,NOTCH3,ACTG1,AKT2,PFKP,ATP1B3,PIK3R5,PIK3R2,MED17
    Apoptosis PPP3R2,IRAK3,TNFRSF1A,CDK5RAP2,PRKACB,PIK3CD,NFKB1,MYD88,Gzmg,CASP2
    Prostate Cancer SPRY1,TGFA,IGF1,INS,HSP90AB1,Ar,MAP2K2,HRAS,SOS1,PDGFB
    Glioma CALM2,KRAS,CALM1,MDM2,CAMK2D,MTOR,HRAS,ARAF,TGFA,GRB2
    Chronic myeloid leukemia PIK3R1,CDK6,PIK3R2,CTBP1,RELA,PIK3R5,BAD,SOS1,MAP2K1,TGFB1
    p signaling pathway GADD45AA,CASP9,RCHY1,SFN,RRM2B,CDK1,CCND2,CCNG2,TSC2,THBS1
    Proteoglycans in cancer PIK3CA,RRAS2,PLAUR,PLAU,ITGAV,FZD5,PDPK1,PRKACA,PPP1CC,HOXD10
    Amyotrophic lateral sclerosis (ALS) NEFH,BID,GRIN2C,DAXX,GRIN2D,PPP3CB,GRIN2A,CYCS,BAD,GRIN2B
    Small cell lung cancer PIK3R5,NFKB1,PTEN,RARB,NFKBIA,TRAF5,CCNE1,NOS2,ITGA3,SKP2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein N-terminus binding ZWINT,EIF3E,KCNB1,STXBP1,KCNQ2,NPAT,ERCC2,SMARCC1,KCNIP2,HAX1
    core promoter sequence-specific DNA binding KLF10,PDX1,PRMT5,ZFP750,SOHLH1,NFYA,CRY1,MLL1,SOHLH2,PROX1
    transcription cofactor binding FOXO3,CHD6,KLF4
    protein C-terminus binding CORO1A,PPP2CB,BLOC1S2,PIAS4,ERCC2,SIAH1A,YWHAQ,ID1,SCLT1,STIP1
    protein self-association CCL5,SLC9A3R1,PABPN1,ZKSCAN17,PCSK9,AGXT,PROSAPIP1,CBR2,S100A7A,CCDC88C
    damaged DNA binding POLD1,H2AFX,ERCC3,TP73,XPA,GTF2H3,RAD23B,TRPC2,TP53,XRCC5
    transcription regulatory region DNA binding THRA,OVOL2,ZNF567,ZNF335,MTERFD3,NKX2-1,TP53,FOXC2,HNF1A,TAF9
    enzyme binding SLC27A2,CCDC99,GBP1,PRKDC,ERN1,PIAS3,PGR,CALU,NCOA1,PICK1
    double-stranded DNA binding DDX11,KIN,MEN1,RAD51L1,HMGB3,APTX,KLF6,CTNNB1,HMGB1,SMAD2

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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