Trp53
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Official Full Name
transformation related protein 53 -
Synonyms
bbl;bfy;bhy;p44;p53;Tp53
Recombinant Proteins
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRP53-17432M | Recombinant Mouse TRP53 Protein | Mammalian Cells | Mouse | His |
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| Trp53-5632M | Recombinant Mouse Trp53 protein, His-tagged | E.coli | Mouse | His | Thr134~Asp387 |
|
| Kit-0642 | p53 Translocation Assay Kit (Cell-Based) | Non |
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| Kit-1030 | Phospho-p53 (Ser15) Translocation Assay Kit (Cell-Based) | Non |
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| Kit-1037 | p53 Nuclear Translocation Assay Kit (Cell-Based) | Non |
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| Kit-2107 | p53 Transcription Factor Activity Assay Kit | Non |
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| Trp53-2140M | Recombinant Mouse Trp53 Protein, His-tagged | E.coli | Mouse | His | Met1-Asp390 |
|
| Trp53-6671M | Recombinant Mouse Trp53 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| TRP53-9648M | Recombinant Mouse TRP53 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TRP53-9648M-B | Recombinant Mouse TRP53 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | HRAS,NOTCH2,RCAN2,AKT1,ATP1B4,PLCB3,SLC16A10,MAP2K1,PLCG1,TP53 |
| Basal cell carcinoma | APC,WNT2B,FZD7,FZD3,WNT10B,GLI2,WNT5A,SETD6,WNT3,WNT7B |
| Neurotrophin signaling pathway | CAMK2D,PIK3CB,IRS1,MAP3K5,MAP3K3,RAP1A,ATF4,SH2B2,RELA,NGFR |
| PIK-Akt signaling pathway | LAMB4,RHEB,EIF4E1B,KRAS,NRAS,TSC1,TNXB,MAP2K1,STK11,YWHAE |
| Wnt signaling pathway | PPP3R2,FZD2,WNT5B,PLCB2,WNT9A,FOSL1,NKD1,WNT11R,FZD3A,DVL1B |
| Measles | IFNA5,DOK1,IL13,CCND3,PIK3CD,CBLB,PRKCQ,TBK1,AKT1,CLEC4M |
| MAPK signaling pathway | FOS,FGF13B,MAP3K6,SOS1,FGF1B,CDC42L,MAP2K6,FGF7,GRB2,RAP1A |
| Apoptosis | BIDA,CASP6,BCL2L1,YWHAQ,PRKAR2AA,BIRC7,DCC,CASP7,PPP3R2,BNIP3LB |
| Herpes simplex infection | SRSF2B,BF2,HLA-F,IFNA13,HCFC1A,PILRA,HLA-E,PTPN11B,HLA-DMB,IRF9 |
Protein Function
Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | NHLH2,TAL1,ARID3A,HSF2,GATA2A,ZFP551,FOXC1,BARX2,NEUROD2,ATF3 |
| chromatin binding | TP73,PAX3,CHD7,C10orf119,PATZ1,KLHDC3,IFT74,TBL1Y,UPF1,TFAP2A |
| double-stranded DNA binding | TDP1,FBXO18,MTERFD1,XRCC3,SP1,PRKDC,SAFB,MTERF3,EGFR,DDX58 |
| transcription factor binding | DIP2C,AGTR2,BCL10,RBFOX2,TMEM173,PER1,GCM1,SRF,NFATC2,SP100 |
| protein phosphatase 2A binding | ARPP19,HMGCR,CTTNBP2NL,SPHK1,ENSAA,PPP2R2A,FOXO1,EIF4EBP1,PPME1,IGBP1 |
| ubiquitin protein ligase binding | ACVR1B,RNF34,FOXO1,UBE2K,WFS1,BECN1,ANKRD32,CCT2,DLG3,GPI |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | MEF2D,SIM1,FOXQ1,HIF3A,ELF5,HIF1AL,ZNF576,TFDP3,FOXA3,TFAP2A |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | STAT3,BHLHA15,NHLH1,HOXD8,GATA1,CREBBP,GRHL3,GATA6,FOXC1,CSRNP1 |
| transcription regulatory region DNA binding | MESP1,H2AFY2,CCNT1,SP1,PPARG,CDK9,TAF7,STAT3,GRHL1,XRCC6 |
Interacting Protein
Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.
lt_sv40;atp;Mdm2
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References
- Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
- Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).
