Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Melanoma PIK3R2,MAPK1,KRAS,MET,FGF2,FGF1,FGF7,PIK3CG,MAPK3,CDH1
    Thyroid hormone signaling pathway NCOR1,PIK3R2,MED12,PIK3CD,PLCB3,GATA4,MDM2,SLCO1C1,ATP1A4,FOXO1
    Chronic myeloid leukemia TGFBR1,GAB2,NFKBIA,NFKB1,MAPK1,SMAD3,CCND1,HDAC2,HRAS,SOS1
    Hepatitis C IFNA13,IRF9,RXRA,PPARA,OAS2,OSTN,OAS1,MAPK1,PIK3CD,IRF1
    Pancreatic cancer CASP9,RB1,PIK3CD,KRAS,PIK3CG,ARHGEF6,IKBKG,BRCA2,RAF1,MAPK1
    Neurotrophin signaling pathway CALML3,CAMK2B,NRAS,CALM3,CALML5,MAPK13,IRAK1,NFKBIB,PSEN2,IRAK4
    Hepatitis B CREB3L3,Ifna15,TNF,RAF1,Ifna11,CCNE2,EGR3,PIK3R3,IFNA13,IFNA5
    Measles DDX58,SLAMF1,IFNB1,NFKB1,IFNA1,RELA,STAT5B,TP73,IFNA12,IL1B
    Prostate Cancer CPN1,INS,IGF1R,LEF1,INSRR,PIK3CG,EP300,CCNE1,MAP2K2,BAD

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding STAT4,KAT2B,E4F1,ATF2,PKNOX2,CREB3L3,SUV39H1,ELF5,CGGBP1,BARHL2
    chromatin binding CUX1,SIX1,ELK1,TP63,ASH1L,CREBBP,HMGB1A,POLG,BRD3,PHF13
    enzyme binding DYM,PRMT1,CAT,TOP2B,PRKCE,NCOA1,HSPA5,YWHAH,LDB1,ZFP36
    DNA binding SCML1,ZNF576,TLR8,RORC,ZBTB5,ZNF454,HOXD10A,POU3F3A,GM14477,NKX2-3
    protein phosphatase 2A binding GRIN3A,STRN,SMG7,RPS6KB1,PPP2R4,ARPP19,CPD,PPME1,TP53,EIF4EBP1
    RNA polymerase II transcription factor binding ATF4,MKX,GATA6,GATA2A,TOX2,GATA2B,TRPS1,GATA4,TP53,GATA1
    core promoter sequence-specific DNA binding NR1D2,NRIP1,NR4A3,TOP1,RORA,MEOX1,TP53,SOHLH1,ZNF750,REST
    protein self-association RYR2,PABPN1,AGXT,CTSC,VAMP2,ZKSCAN17,TRIM32,ABCD3,SLC9A3R1,CBR2
    RNA polymerase II transcription factor activity, sequence-specific DNA binding OVOL1,NHLH2,FOXJ1A,FOXE1,FOXN1,BMPR1A,FOXP3A,ETV6,TP53,SP3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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