Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis TRADD,TRAF2,MAPK3,HIST1H4N,SP100,DDX3X,RHOA,H2-Q10,MAD1L1,GTF2A1L
    Transcriptional misregulation in cancer HIST1H3I,WNT16,TLX1,JMJD1C,HOXA11,IGF1R,SLC45A3,ETV4,LRP2BP,PAX8
    Hepatitis C CLDN15,PPP2R2A,IFNA10,IFNB1,SOCS3,IFNA7,IFNA8,PIK3CB,MAPK12,PIK3CA
    Herpes simplex infection C5,HCFC2,MHC2DCB,HCFC1,TAP1,HLA-DOA,H2-Q10,HLA-G,IRF3,SRSF1B
    Melanoma KRAS,FGF21,IGF1,FGF6,RAF1,MAP2K2,CCND1,BRAF,PDGFD,FGF16
    HTLV-I infection WNT5B,ATF3,NFATC4,ITGB2L,NRP1,PPP3R2,Fzd4,TGFB1,IL2RG,HLA-DOB
    Measles IFNAR2,IFNA13,FAS,CD209B,Fasl,IL2RG,RAB9B,IFNA4,CD28,IFNGR2
    Central carbon metabolism in cancer PFKP,KRAS,G6PD,TP53,MTOR,NTRK3,SIRT6,MAP2K2,HK3,PDHB
    Hepatitis B PIK3CA,TGFB2,STAT2,TIRAP,STAT5B,AKT1,IFNA6,FASLG,STAT4,MYD88

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding PCCA,CYP1A1,NFKBIA,SUPT5H,CYP2C19,PARK7,RPS19BP1,SCN5A,HDAC10,EGFR
    histone deacetylase regulator activity MAPK8,TP53,NCOR1
    protein C-terminus binding HRAS,DLG1,LCK,ZBTB16,CACNA1B,PEX12,TCF4,STIP1,SIAH1A,MID1IP1
    RNA polymerase II transcription factor binding ZFPM2,MIXL1,HCLS1,TBX20,MTA2,ZGLP1,MEF2A,DHX9,GATA5,GATA1A
    damaged DNA binding BRCA1,POLD1,H2AFX,ERCC1,NEIL2,GTF2H3,NEIL1,RAD23A,RPA3,PNKP
    core promoter sequence-specific DNA binding NR1D1,MLL1,NRIP1,ZFHX3,SOX9,ATF4,CHD2,RORA,NFYA,H2AFY
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DLX5,EGR2,NCOA3,EHF,TFAP4,CARF,CEBPA,RUNX2,MIXL1,NR6A1
    protein kinase binding PRKAG1,KCNH1,RAD9A,CCND3,CCNL1B,CDC42,RACGAP1,CALM3,Cd24a,GCSAM
    ATP binding ABCD4,KIF5C,NMRK1,AK7,STYK1,MOV10B.1,SARS2,TNK2,CDK12,TRIO

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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