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Pcolce

  • Official Full Name

    procollagen C-endopeptidase enhancer

  • Overview

    Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
  • Synonyms

    PCOLCE; procollagen C-endopeptidase enhancer; PCPE; PCPE1; PCPE-1; procollagen C-endopeptidase enhancer 1; procollagen C-proteinase enhancer 1; procollagen COOH-terminal proteinase enhancer 1; type 1 procollagen C-proteinase enhancer protein; type I procollagen COOH-terminal proteinase enhancer; procollagen, type 1, COOH-terminal proteinase enhancer;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|S
  • Myc
  • DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCOLCE-30795TH Recombinant Human PCOLCE Wheat Germ N/A 449 amino acids
Human PCOLCE-1580H Recombinant Human PCOLCE, His-tagged E.coli His 169-449aa
Human PCOLCE-372H Recombinant Human PCOLCE Mammalian Cell His
Human PCOLCE-838H Recombinant Human PCOLCE, T7-tagged E.coli T7
Human PCOLCE-6802H Recombinant Human PCOLCE protein, His & S-tagged E.coli His/S Ala315~Cys437 (Accession # Q15113)
Human PCOLCE-3375HCL Recombinant Human PCOLCE 293 Cell Lysate HEK293 N/A
Human PCOLCE-6411H Recombinant Human PCOLCE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PCOLCE-3806H Recombinant Human PCOLCE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PCOLCE-3806H-B Recombinant Human PCOLCE Protein Pre-coupled Magnetic Beads HEK293
Human PCOLCE-4819H Recombinant Human PCOLCE Protein (Ala315-Cys437), N-His tagged E.coli N-His Ala315-Cys437
Human PCOLCE-363HF Recombinant Full Length Human PCOLCE Protein In Vitro Cell Free System 449 amino acids
Mouse Pcolce-6803M Recombinant Mouse Pcolce protein, His-tagged E.coli His Cys36~Ala468 (Accession # Q61398)
Mouse Pcolce-4717M Recombinant Mouse Pcolce Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PCOLCE-4304R Recombinant Rat PCOLCE Protein Mammalian Cell His
Rat PCOLCE-3966R Recombinant Rat PCOLCE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PCOLCE-3966R-B Recombinant Rat PCOLCE Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Pcolce Related Articles
  • Pcolce Related Research Area

Pcolce involved in several pathways and played different roles in them. We selected most pathways Pcolce participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pcolce were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of collagen fibrils and other multimeric structuresABHD1;COL8A1A;COL10A1A;MMP20;COL4A6;BMP1A;COL5A3A;CTSS;BMP1B
Collagen biosynthesis and modifying enzymesCOL15A1B;COL17A1A;COL2A1;ADAMTS2;P3H2;COL28A1;PCOLCEB;COL4A3;EMID2
Collagen formationCOL1A2;COL5A1;COL16A1;CTSL1;COL8A1;LOXL3;COL17A1;COL1A1;COL4A5
Crosslinking of collagen fibrilsBMP1B;ABHD1;PCOLCE;LOXL3;LOXL4;LOX;LOXL2;TLL1;BMP1A
Extracellular matrix organizationASPN;COL8A1A;COL10A1A;COMP;COL3A1;EFEMP1;ADAM9;DAG1;FBLN2

Pcolce has several biochemical functions, for example, collagen binding, heparin binding, peptidase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Pcolce itself. We selected most functions Pcolce had, and list some proteins which have the same functions with Pcolce. You can find most of the proteins on our site.

Function Related Protein
collagen bindingC1QTNF1;HSD17B12;DDR2;MTAP1A;NID1;CD44;CTSB;SMAD4;ITGA2
heparin bindingABI3BP;HRG;RSPO4;VEGFA;COL13A1;SLIT1B;FGFR4;FGF14;APOA5
peptidase activator activityMMP14;PCOLCE2;APP;PSME4B;PCOLCE;MMP25;CLPX;CAV1;PSME4
protein bindingFPR1;FABP3;C7orf50;APOBEC3H;SH3GL3;ITGB4;ZBTB17;SERPINB1A;SETD8

Pcolce has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pcolce here. Most of them are supplied by our site. Hope this information will be useful for your research of Pcolce.

COL18A1; lm-111_human_complex; collagen_vi_human; APP; THBS1; hyaluronan; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_iv_human-3_complex

Raz, V; Sterrenburg, E; et al. Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy. BMC NEUROLOGY 13:-(2013).
Goldsmith, EC; Bradshaw, AD; et al. Cellular Mechanisms of Tissue Fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 304:C393-C402(2013).
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