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PCSK1N

Official Full Name

proprotein convertase subtilisin/kexin type 1 inhibitor
Overview

Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. The protein encoded by this gene appears to function as an endogenous inhibitor of proprotein convertase subtilisin/kexin type 1.
Synonyms

PCSK1N; proprotein convertase subtilisin/kexin type 1 inhibitor; proSAAS; SAAS; pro-SAAS; proprotein convertase 1 inhibitor; granin-like neuroendocrine peptide;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
Fc
Avi
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PCSK1N-2488H	Recombinant human PCSK1N, His-tagged	E.coli	His	Inquiry
Human	PCSK1N-1316HCL	Recombinant Human PCSK1N cell lysate		Non	Inquiry
Human	PCSK1N-2018HFL	Recombinant Full Length Human PCSK1N Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	PCSK1N-1621H-B	Recombinant Human PCSK1N Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	PCSK1N-1621H	Recombinant Human PCSK1N Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Human	PCSK1N-5677H	Recombinant Human PCSK1N Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK	Inquiry
Mouse	Pcsk1n-4720M	Recombinant Mouse Pcsk1n Protein, Myc/DDK-tagged	HEK293T	Myc&DDK	Inquiry
Rat	PCSK1N-4306R	Recombinant Rat PCSK1N Protein	Mammalian Cell	His	Inquiry
Rat	PCSK1N-3967R	Recombinant Rat PCSK1N Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rat	PCSK1N-3967R-B	Recombinant Rat PCSK1N Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PCSK1N involved in several pathways and played different roles in them. We selected most pathways PCSK1N participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK1N were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PCSK1N has several biochemical functions, for example, endopeptidase inhibitor activity, receptor binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK1N itself. We selected most functions PCSK1N had, and list some proteins which have the same functions with PCSK1N. You can find most of the proteins on our site.

Function	Related Protein
endopeptidase inhibitor activity	ITIH2;SPINK1;MUG2;SERPIND1;SERPINA1E;UCHL5;AHSG;RENBP;RECK
receptor binding	HMGCL;NRG1;RSPO1;PKD2;CD160;IL29;POMC;CCL17;MBL2
serine-type endopeptidase inhibitor activity	SERPINH1;SPINT1B;SERPINA1L;WFIKKN2;CCNH;TFPIA;SERPINH2;OVST;FURIN

PCSK1N has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK1N here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK1N.

RAD51

Research Area

Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).

de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).