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PCSK5

Official Full Name

proprotein convertase subtilisin/kexin type 5
Overview

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternate splicing results in two variants encoding distinct isoforms, a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, Jan 2014]
Synonyms

PCSK5; proprotein convertase subtilisin/kexin type 5; PC5; PC6; PC6A; SPC6; subtilase; protease PC6; prohormone convertase 5; proprotein convertase 6; subtilisin/kexin-like protease PC5;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
Wheat Germ
Yeast

Tag

GST
His
SUMO
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PCSK5-122H	Recombinant Human PCSK5, His-tagged	E.coli	His		$159.5 ~~$319~~ / 25μg
Human	PCSK5-30549TH	Recombinant Human PCSK5 protein, GST-tagged	Wheat Germ	GST	804-913	Inquiry
Human	PCSK5-121H	Recombinant Human PCSK5, GST-tagged	Wheat Germ	GST		Inquiry
Human	PCSK5-3370HCL	Recombinant Human PCSK5 293 Cell Lysate	HEK293	Non		Inquiry
Human	PCSK5-4823H	Recombinant Human PCSK5 Protein (Asp115-Met454), N-His tagged	E.coli	His	Asp115-Met454	Inquiry
Mouse	PCSK5-711M	Recombinant Mouse PCSK5 Protein (117-452 aa), His-SUMO-tagged	E.coli	His&SUMO	117-452 aa	Inquiry
Mouse	PCSK5-1480M	Recombinant Mouse PCSK5 Protein (117-452 aa), His-tagged	Yeast	His	117-452 aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein

PCSK5 involved in several pathways and played different roles in them. We selected most pathways PCSK5 participated on our site, such as NGF processing, Signal Transduction, Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
NGF processing	FURINB;PCSK6;NTF7;FURINA;PCSK5
Signal Transduction	RPE65B;RHOF;DTX2;RNF41;APOA4B.2;PPY;STARD8;CCBP2;PROKR1
Signalling by NGF	KIDINS220B;PCSK6;RTN4A;DNAL4B;PCSK5;DNAL4;PRDM4;DNAL4A;RIT1

PCSK5 has several biochemical functions, for example, peptidase activity, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK5 itself. We selected most functions PCSK5 had, and list some proteins which have the same functions with PCSK5. You can find most of the proteins on our site.

Function	Related Protein
peptidase activity	DHH;PRSS40;Casp3;ADAMTS7;FAM105B;C6AST1;ADAM1B;OTUD7A;MASP2
peptide binding	GPR37L1;CALR;NPFFR1;GNRHR;PPIB;CLTA;CCKAR;AVPR2L;ADNP
protein binding	CSTF2T;DICER1;PHF1;DGAT1;YARS2;HNRNPA1;NKX2-5;OSBPL2;SNX6
serine-type endopeptidase activity	KLK2;APEH;TMPRSS11G;PRSS45;F7;ST14;TPP1;KLK9;KLK1B22

PCSK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK5.

NUFIP2; MEOX2; STK16; GLRX3; KRTAP5-9; KRTAP10-7