PDE11A

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PDE11A

Official Full Name phosphodiesterase 11A
Background The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms PDE11A; phosphodiesterase 11A; dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE11A-3354HCL Recombinant Human PDE11A 293 Cell Lysate HEK293 N/A
    Human PDE11A-441H Recombinant Human Phosphodiesterase 11A, GST-tagged Sf9 Insect Cell GST
    Human PDE11A-6162H Recombinant Human PDE11A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse PDE11A-12545M Recombinant Mouse PDE11A Protein Mammalian Cell His
    Mouse Pde11a-4740M Recombinant Mouse Pde11a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PDE11A-4325R Recombinant Rat PDE11A Protein Mammalian Cell His
    Kit-1824 PDE11A Assay Kit N/A

    PDE11A involved in several pathways and played different roles in them. We selected most pathways PDE11A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism IMPDH1; PNP; PRIM2; NT5C2B; AMPD2; AK3; NME3; ADCY1B; POLR3C; PRIM1

    PDE11A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE11A itself. We selected most functions PDE11A had, and list some proteins which have the same functions with PDE11A. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-GMP phosphodiesterase activity PDE5A; PDE11A; PDE6G; PDE9A; PDE6B; PDE6A; PDE6H; PDE10A; PDE6C
    3,5-cyclic-nucleotide phosphodiesterase activity PDE6D; PDE4D; PDE3B; PDE9A; PDE10A; PDE11A; PDE8A; PDE8B; PDE5AB; PDE5A
    cAMP binding PDE4D; CNGA2; RAPGEF3; PDE10A; PRKAR1B; BVES; CNGA4; PRKAR1A; PDE4A; POPDC2
    cGMP binding PDE2A; PDE6H; PRKG1A; PDE6C; PRKG2; CNGA2; CNGA5; PDE10A; PDE6G; PDE11A
    cGMP-stimulated cyclic-nucleotide phosphodiesterase activity TDP2B; USB1; PDE2A; PDE11A; PDE10A
    cyclic-nucleotide phosphodiesterase activity PDE2A; USB1; TDP2B; PDE11A
    metal ion binding ARHGEF38; SP5; CYB561D1; TMPPE; ATP13A; RNF220A; SEMG2; ZNF454; TRIM35-34; ZNF428

    PDE11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE11A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE11A.

    Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
    Tadjine, M; Lampron, A; et al. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). CLINICAL ENDOCRINOLOGY 69:367-373(2008).

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