PDE11A involved in several pathways and played different roles in them. We selected most pathways PDE11A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
ADCY1B; GC2; NME3; TWISTNB; PDE2A; ADCY1A; POLR2E; URAD; PAPSS2B; POLE |
PDE11A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE11A itself. We selected most functions PDE11A had, and list some proteins which have the same functions with PDE11A. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-GMP phosphodiesterase activity |
PDE11A; PDE6C; PDE9A; PDE6B; PDE6H; PDE10A; PDE5A; PDE6G; PDE6A |
| 3,5-cyclic-nucleotide phosphodiesterase activity |
PDE5AB; PDE5A; PDE11A; PDE10A; PDE9A; PDE4D; PDE8B; PDE3B; PDE6D; PDE8A |
| cAMP binding |
PDE4B; CNMPD1; POPDC2; BVES; PDE4D; PDE3A; PDE10A; PDE11A; CNGA2; PRKAR2B |
| cGMP binding |
CNGA3; PRKG2; PDE5A; CNGA2; PDE6H; PDE11A; CNGA1; CNGA4; CNGA5; PDE2A |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity |
PDE11A; PDE10A; PDE2A; TDP2B; USB1 |
| cyclic-nucleotide phosphodiesterase activity |
PDE2A; TDP2B; USB1; PDE11A |
| metal ion binding |
BCL11BA; TRIM27; FBXO30B; INPP5B; ATP8B5; PRKCHB; HINFP; GNAL; ZNF584; ZFP276 |
PDE11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE11A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE11A.
Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Tadjine, M; Lampron, A; et al. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). CLINICAL ENDOCRINOLOGY 69:367-373(2008).
