PDE11A
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Official Full Name
phosphodiesterase 11A
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Background
The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PDE11A; phosphodiesterase 11A; dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356;
- Involved Pathway
- Protein Function
- Interacting Protein
- PDE11A Related Articles
PDE11A involved in several pathways and played different roles in them. We selected most pathways PDE11A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | HPRT1;POLE;PDE6D;POLE3;POLR2A;GMPR;PRPS1B;POLR3B;POLR2EB |
PDE11A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE11A itself. We selected most functions PDE11A had, and list some proteins which have the same functions with PDE11A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-GMP phosphodiesterase activity | PDE6B;PDE6H;PDE6G;PDE6C;PDE5A;PDE11A;PDE9A;PDE6A;PDE10A |
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE5AB;PDE9A;PDE3B;PDE5A;PDE11A;PDE8A;PDE10A;PDE4D;PDE8B |
| cAMP binding | RAPGEF3;HCN2;CNGA4;HCN4;PRKAR2B;PRKAR1B;PDE10A;RAPGEF4;PDE3A |
| cGMP binding | PRKG2;PDE2A;PDE5A;PRKG1A;PDE10A;CNGA4;CNGA2;PRKG1;PDE6G |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | TDP2B;PDE2A;USB1;PDE11A;PDE10A |
| cyclic-nucleotide phosphodiesterase activity | PDE2A;PDE11A;USB1;TDP2B |
| metal ion binding | RBM26;MAP3K4;TNKS2;FTR43;SNAI1A;CCC2;ZNF19;ZNF684;SGSH |
PDE11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE11A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE11A.
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