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Recombinant Human PDE11A Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : PDE11A-6162H
Product Overview : PDE11A MS Standard C13 and N15-labeled recombinant protein (NP_058649) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 104.6 kDa
AA Sequence : MAASRLDFGEVETFLDRHPELFEDY LMRKGKQEMVEKWLQRHSQGQGALG PRPSLAGTSSLAHSTCRGGSSVGGG TGPNGSAHSQPLPGGGDCGGVPLSP SWAGGSRGDGNLQRRASQKELRKSF ARSKAIHVNRTYDEQVTSRAQEPLS SVRRRALLRKASSLPPTTAHILSAL LESRVNLPQYPPTAIDYKCHLKKHN ERQFFLELVKDISNDLDLTSLSYKI LIFVCLMVDADRCSLFLVEGAAAGK KTLVSKFFDVHAGTPLLPCSSTENS NEVQVPWGKGIIGYVGEHGETVNIP DAYQDRRFNDEIDKLTGYKTKSLLC MPIRSSDGEIIGVAQAINKIPEGAP FTEDDEKVMQMYLPFCGIAISNAQL FAASRKEYERSRALLEVVNDLFEEQ TDLEKIVKKIMHRAQTLLKCERCSV LLLEDIESPVVKFTKSFELMSPKCS ADAENSFKESMEKSSYSDWLINNSI AELVASTGLPVNISDAYQDPRFDAE ADQISGFHIRSVLCVPIWNSNHQII GVAQVLNRLDGKPFDDADQRLFEAF VIFCGLGINNTIMYDQVKKSWAKQS VALDVLSYHATCSKAEVDKFKAANI PLVSELAIDDIHFDDFSLDVDAMIT AALRMFMELGMVQKFKIDYETLCRW LLTVRKNYRMVLYHNWRHAFNVCQL MFAMLTTAGFQDILTEVEILAVIVG CLCHDLDHRGTNNAFQAKSGSALAQ LYGTSATLEHHHFNHAVMILQSEGH NIFANLSSKEYSDLMQLLKQSILAT DLTLYFERRTEFFELVSKGEYDWNI KNHRDIFRSMLMTACDLGAVTKPWE ISRQVAELVTSEFFEQGDRERLELK LTPSAIFDRNRKDELPRLQLEWIDS ICMPLYQALVKVNVKLKPMLDSVAT NRSKWEELHQKRLLASTASSSPASV MVAKEDRNTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : PDE11A phosphodiesterase 11A [ Homo sapiens (human) ]
Official Symbol : PDE11A
Synonyms : PDE11A; phosphodiesterase 11A; dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356;
Gene ID : 50940
mRNA Refseq : NM_016953
Protein Refseq : NP_058649
MIM : 604961
UniProt ID : Q9HCR9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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