Recombinant Human Phosphodiesterase 11A, GST-tagged

• Cat.No.: PDE11A-441H
• Product Overview: Recombinant Human PDE11A, full length with N-terminal GST tag expressed in aBaculovirus infected Sf9 cellexpression system. MW = 131kDa.

Specification

• Cat. No.: PDE11A-441H
• Description: Dual 3",5"-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3",5"-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3",5"-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5"-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Sf9 cell.
• Purity: >80%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: PDE11A phosphodiesterase 10A [ Homo sapiens ]
• Synonyms: PDE11A; phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356; EC 3.1.4.17; EC 3.1.4.35; OTTHUMP00000205272; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cyclic nucleotide phosphodiesterase 11A; dual 3",5"-cyclic-AMP and -GMP phosphodiesterase 11A
• Gene ID: 50940
• mRNA Refseq: NM_001077196
• Protein Refseq: NP_001070664
• MIM: 604961
• UniProt ID: Q9HCR9
• Chromosome Location: 2q31.2
• Pathway: Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
• Function: 3",5"-cyclic-GMP phosphodiesterase activity; cAMP binding; cGMP binding; hydrolase activity; magnesium ion binding