PDE12
-
Official Full Name
phosphodiesterase 12 -
Overview
Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP -
Synonyms
PDE12;phosphodiesterase 12;2,5-phosphodiesterase 12;2 PDE;2 phosphodiesterase;DKFZp667B1218;2-PDE;2-phosphodiesterase
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- His
- GST
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PDE12 involved in several pathways and played different roles in them. We selected most pathways PDE12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PDE12 has several biochemical functions, for example, metal ion binding,poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE12 itself. We selected most functions PDE12 had, and list some proteins which have the same functions with PDE12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF664,ZFP458,PGCP,LMO7A,MAT2AB,CYP4T8,MTMR4,RPAP2,CNOT4B,PDE1C |
| poly(A)-specific ribonuclease activity | CNOT8,PAN2,CNOT6,TOE1,CNOT6L,CNOT7,PARN |
Interacting Protein
PDE12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE12.
UBL4A;BAG6;SGTB;VWA9;SORT1;Rhoa;SIRT4
Resources
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References
- Braun, J; Kiltz, U; et al. Emerging drugs for the treatment of axial and peripheral spondyloarthritis. EXPERT OPINION ON EMERGING DRUGS 20:1-14(2015).
- Felquer, MLA; Soriano, ER; et al. New treatment paradigms in psoriatic arthritis: an update on new therapeutics approved by the US Food and Drug Administration. CURRENT OPINION IN RHEUMATOLOGY 27:99-106(2015).
