pdx1
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  • Official Full Name
  • pancreatic and duodenal homeobox 1
  • Background
  • The orphan nuclear receptor, steroidogenic factor 1 (STF-1, also called Ad4BP), encoded by the NR5A1 gene, displays a high degree of homology to the Drosophila nuclear receptor fushi tarazu factor 1 and plays a fundamental role in the development and func
  • Synonyms
  • PDX1; pancreatic and duodenal homeobox 1; insulin promoter factor 1, homeodomain transcription factor , IPF1; pancreas/duodenum homeobox protein 1; IDX 1; MODY4; PDX 1; somatostatin transcription factor 1; STF 1; IPF-1; IUF-1; glucose-sensitive factor; insulin upstream factor 1; islet/duodenum homeobox-1; pancreatic-duodenal homeobox factor 1; somatostatin-transactivating factor 1; insulin promoter factor 1, homeodomain transcription factor; GSF; IPF1; IUF1; IDX-1; PDX-1; STF-1
Cat.#:PDX1-147HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDX1 protein, Arginine-tagged
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Cat.#:PDX1-29672THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PDX1
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Cat.#:PDX1-393HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDX1 Protein, His-tagged
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Cat.#:PDX1-12601MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDX1 Protein
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Cat.#:Pdx1-1573MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdx1 protein, His & GST-tagged
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Cat.#:PDX1-4362RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDX1 Protein
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Cat.#:PDX1-9011ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDX1
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Cat.#:PDX1-176HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Pancreatic And Duodenal Homeobox 1
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Cat.#:PDX1-3318HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDX1 293 Cell Lysate
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Involved Pathway

PDX1 involved in several pathways and played different roles in them. We selected most pathways PDX1 participated on our site, such as Insulin secretion, Type II diabetes mellitus, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Insulin secretion
CAMK2B; Adcy4; RYR2; KCNN3; TRPM4; FXYD2; PRKCB; PRKACB; ATP1A4; SNAP25
Type II diabetes mellitus
MAPK3; IRS4; HK1; PKM; INS2; IRS2; PDX1; HK2; TNF; SOCS3
Maturity onset diabetes of the young
SLC2A2; PKLR; NR5A2; NKX6-1; HNF4A; HES1; IAPP; RFX6; PAX6; MAFA

Protein Function

PDX1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDX1 itself. We selected most functions PDX1 had, and list some proteins which have the same functions with PDX1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein RFX1; NOBOX; CARF; NACC2; MSX2; GMEB1; MYF6; CEBPE; AKNA; ARID3B
Function chromatin binding
Related Protein SREBF1; SIRT6; NOC2L; CHAF1B; ORC1L; KLF14; MLH3; LOXL2; GATA2A; CSNK2B
Function core promoter sequence-specific DNA binding
Related Protein SIRT1; SP1; MEOX1; NR4A3; SOX9; ESR2; PPARG; REST; SOX4; NRF1
Function protein complex binding
Related Protein DLG4; PEX26; BAX; VDAC1; SIX2; TELO2; AP2A1; CDH2; NCK2; KCTD5
Function protein heterodimerization activity
Related Protein TIMELESS; SRY; HIST1H2AB; TYRO3; SMC3; SPTA1; EPAS1; HIST1H2AF; HIST2H3C; SYT16
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein FOXC1; NKX2-1; MEF2A; HNF1B; RELA; NFIX; NFATC1; SRF; TLE4; CREB1
Function transcription factor activity, sequence-specific DNA binding
Related Protein WNT5A; ZFP14; GTF3A; CREB5; ZFP382; ZNF544; HSF2; MYOG; XBP1; E2F5
Function transcription factor binding
Related Protein SUFU; TP53; PIAS1; GTF2F1; SIRT1; NR0B1; RNF4; FOXA2; MSX2; BRD7

Interacting Protein

PDX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDX1.
Dlg4; PASK; npm_alk

PDX1 Related Articles

Gilabert, M; Calvo, E; et al. Pancreatic Cancer-Induced Cachexia Is Jak2-Dependent in Mice. JOURNAL OF CELLULAR PHYSIOLOGY 229:1437-1443(2014).
Kang, R; Zhang, QH; et al. Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice. GASTROENTEROLOGY 146:1097-U338(2014).