PEPD
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Official Full Name
peptidase D
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Overview
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PEPD; peptidase D; xaa-Pro dipeptidase; prolidase; MGC95081; Imidodipeptidase; MGC10905; Pep 4; Pep4; PEPD_HUMAN; Peptidase 4; Proline dipeptidase; X pro dipeptidase; X-Pro dipeptidase; aminoacyl-L-proline hydrolase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PEPD Related Articles
PEPD involved in several pathways and played different roles in them. We selected most pathways PEPD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PEPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
PEPD has several biochemical functions, for example, aminopeptidase activity, dipeptidase activity, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEPD itself. We selected most functions PEPD had, and list some proteins which have the same functions with PEPD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminopeptidase activity | PHEX;LTA4H;ENPEP;LAP3;DPP9;TPP2;RNPEP;TRHDE;METAP2A |
| dipeptidase activity | SCRN3;CNDP2;DPEP3;CNDP1;FOLH1;SCRN2;DPEP2;NAALAD2;SCRN1 |
| manganese ion binding | NUDT7;SLC11A2;ARG1;ABL2;TDP2B;GALNT2;ATP2C1;CDIPT;SOD2 |
| metallocarboxypeptidase activity | PEPD;CPB1;AGBL5;CPA5;CPE;CPA3;AGTPBP1;CPD;CPA4 |
| protein binding | VEGFB;DYNLT1;BLVRA;ZNF511;PKN1;RBBP4;ITPR1;AHSP;Ccl27a |
PEPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEPD here. Most of them are supplied by our site. Hope this information will be useful for your research of PEPD.
TERF1; PKM; SPP1; ATXN1; glnQ; tig; comEA; q81mj8_bacan; acnA; q8cl08_yerpe
- Q&As
- Reviews
Q&As (7)
Ask a questionPSCA is being explored for diagnostic applications, and its detection may aid in the early diagnosis of prostate cancer.
While primarily studied in the context of cancer, PSCA's role in non-cancer physiological processes is an area of ongoing research.
PSCA expression has been reported in various tissues, including the bladder, kidney, stomach, and colon.
Various therapeutic approaches targeting PSCA, including immunotherapy and small molecules, are being investigated for prostate cancer treatment.
PSCA is a cell surface glycoprotein that belongs to the Ly-6/Thy-1 family.
Yes, PSCA expression levels can vary among individuals, and its upregulation is associated with certain cancers.
Overexpression of PSCA in cancer is associated with increased proliferation, invasion, and resistance to apoptosis.
Customer Reviews (3)
Write a reviewThe product's ability to assist in data interpretation reduced the burden on our research team.
Clear and accessible protocols made it easy for all team members to contribute to our research efforts.
The product's compatibility with various instruments and techniques promoted teamwork in our interdisciplinary projects.
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