pfdn2
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  • Official Full Name
  • prefoldin subunit 2
  • Background
  • This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
  • Synonyms
  • PFDN2; prefoldin subunit 2; prefoldin 2; OTTHUMP00000029707; PFD2
Cat.#:PFDN2-1655HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFDN2, GST-tagged
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Cat.#:PFDN2-28101THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFDN2, His-tagged
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Cat.#:PFDN2-2857HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prefoldin Subunit 2, His-tagged
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Cat.#:PFDN2-561HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFDN2, His tagged
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Cat.#:PFDN2-12659MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PFDN2 Protein
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Cat.#:PFDN2-4389RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PFDN2 Protein
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Cat.#:PFDN2-3380RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PFDN2 Protein, His-tagged
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Cat.#:PFDN2-4281ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PFDN2
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Cat.#:PFDN2-3280HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PFDN2 293 Cell Lysate
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Involved Pathway

PFDN2 involved in several pathways and played different roles in them. We selected most pathways PFDN2 participated on our site, such as Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chaperonin-mediated protein folding
FBXW9; CCT5; TUBA3D; TCP1; TUBB4A; CCT8; KIFC3; CCT3; CCT2; FBXL5
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
CCT5; CCT3; PFDN6; CCT7; VBP1; PFDN2; PFDN1; TUBA1B; CCT6A; CCT8
Metabolism of proteins
CST3; A4GNT; CBX4; WIPI1; CNIH2; ARSH; EXOC8; KLHDC3; BET1; SPON2
Prefoldin mediated transfer of substrate to CCT/TriC
PFDN1; CCT7; CCT6A; PFDN2; PFDN5; PFDN4; PFDN6; VBP1
Protein folding
NOP56; ARL2; PFDN5; FBXW9; VBP1; CCT6A; FKBP9; TBCD; PFDN2; TBCB
TNF-alpha/NF-kB Signaling Pathway
USP2; SMARCE1; KIAA1967; PEG3; DAP; MCC; TRPC4AP; SMARCB1; TNIP1; UNC5CL

Protein Function

PFDN2 has several biochemical functions, for example, protein binding, protein binding involved in protein folding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN2 itself. We selected most functions PFDN2 had, and list some proteins which have the same functions with PFDN2. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SCO1; C9orf16; CDK10; NUP62L; P2RY1; CHMP2A; PRKD2; SRI; SEPHS1; NQO2
Function protein binding involved in protein folding
Related Protein CALR; CD74; RIC3; CALR3; HSPA1A; PFDN1; CLGN; PFDN2; PDCL3; HSPA1B
Function unfolded protein binding
Related Protein DNAJA3A; PFDN5; CHAF1A; HSP90AA1; UGGT1; DNAJB1B; HSPA8; DNAJA3; GRXCR2; PFDN2

Interacting Protein

PFDN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN2.
URI1; f_hcvh; PPP1CC; RPAP3; GNB5; POLR3A; EIF1B; GTF2F2; MCC; VHL; EIF6; ARF6; Tubb4b; IKBKE

PFDN2 Related Articles

Lee, HN; Park, SH; et al. Proteomic profiling of tumor-initiating cells in HT-29 human colorectal cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 427:171-177(2012).
Horejsi, Z; Takai, H; et al. CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability. MOLECULAR CELL 39:839-850(2010).