PGR

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PGR

Official Full Name progesterone receptor
Background This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
Synonyms PGR; progesterone receptor; PR; NR3C3; nuclear receptor subfamily 3 group C member 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PGR-106H Recombinant Human Progesterone receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
    Human PGR-182H Recombinant Human Progesterone Receptor E.coli N/A
    Human PGR-183H Recombinant Human PGR protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PGR-20H Recombinant Human PGR protein, GST-tagged Insect Cell GST
    Human PGR-228H Recombinant Human PGR, StrepII-tagged Human Cell Strep II
    Human PGR-29707TH Recombinant Human PGR E.coli N/A
    Human PGR-5861H Recombinant Human PGR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PGR-6753H Recombinant Human PGR protein, His & T7-tagged E.coli His/T7
    Mouse Pgr-4828M Recombinant Mouse Pgr Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PGR-4410R Recombinant Rat PGR Protein Mammalian Cell His
    Rat Pgr-6754R Recombinant Rat Pgr protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque PGR-3395R Recombinant Rhesus monkey PGR Protein, His-tagged Mammalian Cell His
    Chicken PGR-6814C Recombinant Chicken PGR Mammalian Cell His
    Zebrafish PGR-7617Z Recombinant Zebrafish PGR Mammalian Cell His

    PGR involved in several pathways and played different roles in them. We selected most pathways PGR participated on our site, such as Oocyte meiosis, Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oocyte meiosis YWHAG; ADCY2B; YWHABB; INSB; PPP3CA; CCNE2; PRKACBB; CALM2A; PPP2R5EA; ANAPC4
    Progesterone-mediated oocyte maturation RPS6KAL; FZR1; PGR; RPS6KA6; CDK1; PRKACG; MAPK10; MAD2L1; GNAI2; CPEB4

    PGR has several biochemical functions, for example, ATPase binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGR itself. We selected most functions PGR had, and list some proteins which have the same functions with PGR. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding PTPN3; ATP1B3; PKD2; CHMP4A; S100A1; METTL21A; NKAIN1; DRD1A; ZNHIT6; GABARAPL2
    DNA binding MED26; ZFP146; ANO9A; CR2; RARG; ZNF729; PAX4; MEF2AA; ZNF157; Trl
    RNA polymerase II core promoter proximal region sequence-specific DNA binding POU4F2; JUND; KLF5; PGR; CEBPA; MTF1; DDN; FOXD1; SOX10; CLOCK
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR1D2; NR2E3; ESR2; RXRA; NR0B1; NR6A1; NR4A2A; RORC; NR4A2; ESRRA
    enzyme binding EIF2AK3; USP22; CAV1; EGFR; MLEC; HIF1A; AKT1; DDC; CNTNAP2; ADORA2A
    protein binding HAND1; FASTKD5; WDHD1; SNRNP40; PRPF6; ACAT2; MCEE; IL17RE; RRAGB; KCND2
    receptor binding WNT7AA; LRRC4B; UTS2; NPPA; SERPINE1; SRMS; LAMA1; APOL2; LAMA2; SERPINE2
    steroid binding NR3C1; AKR1D1; FAM84B; ESRRG; PGR; HSD3B4; PAQR7; PAQR5A; PAQR7A; HSD11B2
    steroid hormone receptor activity VDRA; VDR; PAQR7A; RXRAA; NR1I2; NR2F5; ESRRA; NR1D1; OR51E2; NR1D2A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PITX3; MEF2C; MITF; MYOG; GLI3; NKX2-8; NCOA3; SRF; CEBPB; NFYC
    zinc ion binding RBM4.1; MSRB1; RNF207; LTA4H; NR1H2; KLF4; NR2F1A; PJA1; TRIML1; TCEA1

    PGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGR here. Most of them are supplied by our site. Hope this information will be useful for your research of PGR.

    CUEDC2; STAT3; SP1; r_5020_promegestone; PRMT2; JDP2; SMARCD1

    Tosovic, A; Bondeson, AG; et al. T3 levels in relation to prognostic factors in breast cancer: a population-based prospective cohort study. BMC CANCER 14:-(2014).
    Yardley, DA; Tripathy, D; et al. Long-term survivor characteristics in HER2-positive metastatic breast cancer from registHER. BRITISH JOURNAL OF CANCER 110:2756-2764(2014).

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