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PIAS3

  • Official Full Name

    protein inhibitor of activated STAT, 3

  • Overview

    This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of;transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like;modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It;directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced;transcript variants of this gene have been identified, but the full-length nature of some of these variants has not;been determined.
  • Synonyms

    PIAS3; protein inhibitor of activated STAT, 3; E3 SUMO-protein ligase PIAS3; FLJ14651; zinc finger; MIZ type containing 5; ZMIZ5; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIAS3-1704H Recombinant Human PIAS3, GST-tagged E.coli GST 277-628aa
Human PIAS3-1245H Recombinant Human PIAS3 protein, His & GST-tagged E.coli His/GST Val11~Leu280 (Accession # Q9Y6X2)
Human PIAS3-3202HCL Recombinant Human PIAS3 293 Cell Lysate HEK293 N/A
Mouse PIAS3-12770M Recombinant Mouse PIAS3 Protein Mammalian Cell His
Mouse PIAS3-6719M-B Recombinant Mouse PIAS3 Protein Pre-coupled Magnetic Beads HEK293
Mouse PIAS3-6719M Recombinant Mouse PIAS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIAS3-4443R Recombinant Rat PIAS3 Protein Mammalian Cell His
Rat PIAS3-4103R-B Recombinant Rat PIAS3 Protein Pre-coupled Magnetic Beads HEK293
Rat PIAS3-4103R Recombinant Rat PIAS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIAS3 Related Research Area
  • PIAS3 Related Signal Pathway

PIAS3 involved in several pathways and played different roles in them. We selected most pathways PIAS3 participated on our site, such as Androgen receptor signaling pathway, C-MYB transcription factor network, Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Androgen receptor signaling pathwayDAXX;NR2C2;PSMC3IP;PNRC1;SMARCE1;DSTN;TGFB1I1;ZMIZ1;HTATIP
C-MYB transcription factor networkMYF6;TOM1;SMARCA2;ADORA2B;PPID;SLC25A3;PTCRA;CDK6;YEATS4
Coregulation of Androgen receptor activitySNURF;KDM3A;NRIP1;CMTM2;SVIL;PIAS3;TGFB1I1;CMTM2A;CTDSP2
DNA RepairCLSPN;RAD1;UIMC1;YY1;BRE;DDB2;RAD9;CHEK2;EYA3
Formation of Incision Complex in GG-NERDDB2;USP45;PIAS3;CETN2;PARP2;RNF111;CHD1L;DDB1
Global Genome Nucleotide Excision Repair (GG-NER)COPS5;INO80C;COPS3;DDB2;USP45;COPS4;PARP2;NFRKB;COPS7A
IL6-mediated signaling eventsLMO4;PIAS3;CRP;JUNB
Interferon type IGNB2L1;PIAS3

PIAS3 has several biochemical functions, for example, SUMO transferase activity, enzyme binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS3 itself. We selected most functions PIAS3 had, and list some proteins which have the same functions with PIAS3. You can find most of the proteins on our site.

Function Related Protein
SUMO transferase activityUBE2I;UBE2IB;PIAS3;SUMO4;UBE2IA;NSMCE2;TOPORS;PIAS4;SUMO1
enzyme bindingSLC18A1;CCDC99;Slc4a2;HYAL2;GNB2L1;PCBP2;UGT1A6A;ARRB2;NOTCH1
ligase activityTRIM58;GLULC;RNF4;AMFR;RNF13;PCXB;RNF149;PARK2;MKRN1
potassium channel regulator activityKCNE2;KCNAB2;SGK2A;KCNAB3;KCNMB4;SGK2B;KCNMB1;DLG1;SGK3
protein C-terminus bindingSNTG1;PDZD11;CDC20;YWHAQ;PPP2CB;CAV3;DST;SAE1;IFT52
protein N-terminus bindingNCOR2;ERCC3;PEX19;TP53;MYO7A;VPS25;HESX1;NCOA1;DAXX
protein bindingABCB1;CUTC;EXOSC10;DUSP7;SCP2;PLOD3;AP2M1;CBLL1;FLII
zinc ion bindingRNF2;PRICKLE1B;PPARAA;MMP17;ZDHHC20A;ZCWPW2;LIMK1;PDLIM4;PHF10

PIAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS3.

MBD1; UBE2I; HNRNPK; GFI1; PRPF40A; SKIL; GLUL; UBA1; STAT3; yscQ; GEMIN4; PPP1CA; PSMC1; SATB1; CREM; SREBF2; q5ni67_fratt

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