PIAS3
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Official Full Name
protein inhibitor of activated STAT, 3
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Overview
This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of;transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like;modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It;directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced;transcript variants of this gene have been identified, but the full-length nature of some of these variants has not;been determined. -
Synonyms
PIAS3; protein inhibitor of activated STAT, 3; E3 SUMO-protein ligase PIAS3; FLJ14651; zinc finger; MIZ type containing 5; ZMIZ5; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- Fc
- Avi
- Non
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PIAS3-1704H | Recombinant Human PIAS3, GST-tagged | E.coli | GST | 277-628aa | |
Human | PIAS3-1245H | Recombinant Human PIAS3 protein, His & GST-tagged | E.coli | His&GST | Val11~Leu280 |
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Human | PIAS3-3202HCL | Recombinant Human PIAS3 293 Cell Lysate | HEK293 | Non |
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Mouse | PIAS3-12770M | Recombinant Mouse PIAS3 Protein | Mammalian Cell | His |
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Mouse | PIAS3-6719M-B | Recombinant Mouse PIAS3 Protein Pre-coupled Magnetic Beads | HEK293 |
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Mouse | PIAS3-6719M | Recombinant Mouse PIAS3 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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Rat | PIAS3-4443R | Recombinant Rat PIAS3 Protein | Mammalian Cell | His |
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Rat | PIAS3-4103R-B | Recombinant Rat PIAS3 Protein Pre-coupled Magnetic Beads | HEK293 |
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Rat | PIAS3-4103R | Recombinant Rat PIAS3 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- PIAS3 Related Signal Pathway
PIAS3 involved in several pathways and played different roles in them. We selected most pathways PIAS3 participated on our site, such as Androgen receptor signaling pathway, C-MYB transcription factor network, Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Androgen receptor signaling pathway | RAD9A;SMAD3B;KAT7;RNF14;CTNNB2;CREBBP;PATZ1;CARM1;RAD54L2 |
C-MYB transcription factor network | MYB;ADORA2B;PTCRA;TRIM28;CLTA;PPID;LECT2;CREBBP;PRTN3 |
Coregulation of Androgen receptor activity | PA2G4;TCF4;CTDSP2;MAK;CMTM2;ZMIZ1;SVIL;TMF1;KDM1A |
DNA Repair | YY1A;COPS6;COPS3;RAD9;COPS8;KIAA0101;EME2;PARP2;ASCC1 |
Formation of Incision Complex in GG-NER | DDB1;PARP2;CHD1L;RNF111;DDB2;PIAS3;CETN2;USP45 |
Global Genome Nucleotide Excision Repair (GG-NER) | USP45;CHD1L;COPS7A;COPS4;INO80E;INO80C;NFRKB;YY1A;ACTL6A |
IL6-mediated signaling events | PIAS3;LMO4;CRP;JUNB |
Interferon type I | PIAS3;GNB2L1 |
PIAS3 has several biochemical functions, for example, SUMO transferase activity, enzyme binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS3 itself. We selected most functions PIAS3 had, and list some proteins which have the same functions with PIAS3. You can find most of the proteins on our site.
Function | Related Protein |
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SUMO transferase activity | CBX4;NSMCE2;UBE2IB;UBE2I;SUMO3;SUMO1;TOPORS;PIAS4;SUMO4 |
enzyme binding | MARCH6;EHHADH;MTA1;UBE2I;RAD9A;CABYR;RCOR3;AXIN1;UGT1A6A |
ligase activity | TRIM24;UBE2KA;RNF152;MYLIP;TRIM17;NSMCE2;TRIM33;RNF170;RNF126 |
potassium channel regulator activity | LRRC26;KCNIP1;SGK2A;KCNE1;ANK2;SUMO1;AMIGO1;KCNS3;PIAS3 |
protein C-terminus binding | STIP1;PEX26;DLG3;ERCC2;VPS4B;DAB2;DLG1;MAP3K7;PDZD11 |
protein N-terminus binding | TARBP2;STX5;SCT;GTF2H3;DAXX;EXOC5;PEX19;PARP1;ALOX5AP |
protein binding | GDNF;TFAM;RBMY1F;HPCAL4;ARIH1;GFER;CRB3;KLF15;GAD2 |
zinc ion binding | ZADH2;ZDHHC11;CPA4;MEP1A;CA8;HRG;LMO4A;ADAM21;NR5A1A |
PIAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS3.
MBD1; UBE2I; HNRNPK; GFI1; PRPF40A; SKIL; GLUL; UBA1; STAT3; yscQ; GEMIN4; PPP1CA; PSMC1; SATB1; CREM; SREBF2; q5ni67_fratt
Research Area
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