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PIAS4

  • Official Full Name

    protein inhibitor of activated STAT, 4

  • Overview

    The PIAS (protein inhibitor of activated Stat) proteins, which include PIAS1, PIAS3, PIASx, and PIASy, were originally characterized based on their interaction with the Stat family of transcription factors (1,2). PIAS1, PIAS3, and PIASx interact with and
  • Synonyms

    PIAS4; protein inhibitor of activated STAT, 4; E3 SUMO-protein ligase PIAS4; FLJ12419; Piasg; PIASY; zinc finger; MIZ type containing 6; ZMIZ6; PIAS-gamma; zinc finger, MIZ-type containing 6; protein inhibitor of activated STAT protein 4; protein inhibito;

  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • His (Fc)
  • Avi
  • N/A
  • N
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIAS4-3201HCL Recombinant Human PIAS4 293 Cell Lysate HEK293 N/A
Human PIAS4-1674H-B Recombinant Human PIAS4 Protein Pre-coupled Magnetic Beads HEK293
Human PIAS4-246H Recombinant Human PIAS4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PIAS4-1442HFL Recombinant Full Length Human PIAS4 Protein, C-Flag-tagged Mammalian cells Flag
Human PIAS4-1674H Recombinant Human PIAS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pias4-4850M Recombinant Mouse Pias4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pias4-1939M Recombinant Mouse Pias4 Protein, His-tagged E.coli N-His Val12-Leu272
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIAS4 Related Signal Pathway

PIAS4 involved in several pathways and played different roles in them. We selected most pathways PIAS4 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayIKBKB;LTB;BIRC3;GM13304;TRAF5;PLAU;NFKB2;PIDD1;TNFAIP3
Ubiquitin mediated proteolysisBIRC2;PIAS2;UBE2D2A;CUL3A;UBE2D1;CDC26;CDC16;RHOBTB1;UBE2Z
Jak-STAT signaling pathwayIFNPHI1;AOX1;IL6;IL20;IL2RB;IFNA17;LIF;JAK2A;IL28RA

PIAS4 has several biochemical functions, for example, DNA binding, SUMO ligase activity, SUMO transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS4 itself. We selected most functions PIAS4 had, and list some proteins which have the same functions with PIAS4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSP2;ZNF784;GM14482;HMGA2;ERCC2;NKX2.4B;HOXB3A;MYC;HNF1BA
SUMO ligase activityPIAS4;PIAS2;PIAS1
SUMO transferase activityPIAS3;TOPORS;SUMO1;NSMCE2;MUL1;PIAS4;CBX4;UBE2IA;SUMO3
ligase activitySHRPRBCK1R;UBE3B;TRAF6;RNF123;RANBP2;ADSSL;GLULC;RNF170;TRIM63
protein C-terminus bindingSHANK3;BLOC1S2;SDC1;ATP2A2;PDZD11;TFCP2;YAP1;PEX1;ZBTB16
protein bindingC16orf59;FEM1C;AGAP2;RORB;TCEA1;EXOC8;GEMIN8;MEA1;EIF4G1
ubiquitin protein ligase bindingDLG3;RALB;POLR2A;UBE2C;RFFL;UBE2NA;SCAMP3;CDC34A;FLJ11011L
zinc ion bindingMECR;ZCCHC10;KDM2A;ZMYM4;LHX9;RYBPA;BHMT2;TOPORS;GATA4

PIAS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS4.

PARP1; Tp53; TADA3; TP53; HTT; SUMO2; MEN1; PRMT5; XRCC6

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