PIM2

  • Official Full Name

    proviral integration site 2

  • Overview

    PIM-2 belongs to a family of cytoplasmic serine/threonine protein kinases that consists of two other members, PIM-1 and PIM-3. Expression of this protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is also highly expressed in human leukemic and lymphoma cell lines. The gene is also expressed in primary spermatocytes. The results suggest a role for PIM-2 in proliferating cells as well as during meiosis. PIM-2 is thought to be a mediator of p53 mediated apoptosis inhibition by interleukin 3, which supports its role in the formation of various tumors including lymphomas.
  • Synonyms

    PIM2; proviral integration site 2; serine/threonine-protein kinase pim-2; Pim-2; DXCch3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIM2-1456H Active Recombinant Human PIM2, GST-tagged Sf9 Insect Cell GST Full length
Human PIM2-193H Active Recombinant Human PIM2(2-end) Protein, N-GST-tagged E.coli GST 2-end
Human PIM2-727H Recombinant Human Pim-2 Oncogene, GST-His Sf9 Insect Cell GST
Human PIM2-29589TH Recombinant Human PIM2 N/A
Human PIM2-393H Recombinant Human Pim-2 Oncogene, GST-tagged, Active Sf9 Insect Cell GST
Human PIM2-1721H Recombinant Human PIM2, GST-tagged E.coli GST 1-311aa
Human PIM2-206H Recombinant Human PIM2, His-tagged E.coli His 1-311aa
Human PIM2-3180HCL Recombinant Human PIM2 293 Cell Lysate HEK293 N/A
Human PIM2-1681H Recombinant Human PIM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PIM2-1388HFL Recombinant Full Length Human PIM2 Protein, C-Flag-tagged Mammalian cells Flag
Human PIM2-0922H Recombinant Human PIM2 Protein (M1-P311), His tagged E.coli His M1-P311
Human PIM2-4317H Recombinant Human PIM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PIM219170H Recombinant Human PIM2 (1-311) Protein
Human PIM2-0921H Recombinant Human PIM2 Protein (M1-P311), Tag Free E.coli No tag M1-P311
Human PIM220874H Recombinant Human PIM2 (22-288) Protein
Human PIM2-1681H-B Recombinant Human PIM2 Protein Pre-coupled Magnetic Beads HEK293
Human PIM2-8178HF Active Recombinant Full Length Human PIM2 Protein, GST-tagged Insect (sf21) GST 1-311
Human PIM2-3959H Recombinant Human PIM2 Protein (Leu82-Asp292), N-His tagged E.coli N-His Leu82-Asp292
Mouse PIM2-12816M Recombinant Mouse PIM2 Protein Mammalian Cell His
Mouse Pim2-1503M Recombinant Mouse Pim2 protein, His & T7-tagged E.coli His/T7 Gly98~Cys319 (Accession # Q62070)
Mouse PIM2-6746M Recombinant Mouse PIM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pim2-4869M Recombinant Mouse Pim2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PIM2-6746M-B Recombinant Mouse PIM2 Protein Pre-coupled Magnetic Beads HEK293
Rat Pim2-1504R Recombinant Rat Pim2 protein, His & T7-tagged E.coli His/T7 Leu34~Glu292 (Accession # F1M419)
Rhesus Macaque PIM2-3437R Recombinant Rhesus monkey PIM2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIM2-3255R Recombinant Rhesus Macaque PIM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PIM2-3255R-B Recombinant Rhesus Macaque PIM2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PIM2 involved in several pathways and played different roles in them. We selected most pathways PIM2 participated on our site, such as Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acute myeloid leukemiaPIM2;TCF7;TCF7L2;PIK3R1;AKT2;HRAS;GRB2;IKBKB;ZBTB16

PIM2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM2 itself. We selected most functions PIM2 had, and list some proteins which have the same functions with PIM2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDGKE;MYO3A;RUNX2;PFKFB3;DNAH11;AKT1;DDX58;BCS1L;C9orf96
protein bindingAPIP;CDC5L;CASP7;DDX42;SELL;PKIA;SPATA24;TBX24;ALDH7A1
protein serine/threonine kinase activityMAST4;CPNE3;RPS6KB2;STK38A;PIK3CG;MAP2K2A;CSNK2A1;NEK11;SIK2A

PIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM2.

ZNF821; MDM2; IKBKG; HSP90AB1; q96bx3_human; NDUFB8; HNRNPH3; RPL21; GSK3B; ATXN1; FBXO18; NUP98; PPIL2; CCDC84; PRCC; GPKOW; TOE1; CLK4

Research Area

Related articles

Jiang, YW; Soong, TD; et al. Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma. PLOS ONE 7:-(2012).
Hallermann, C; Niermann, C; et al. New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 56:588-597(2007).
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