PKMYT1
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Official Full Name
protein kinase, membrane associated tyrosine/threonine 1
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Overview
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
PKMYT1; protein kinase, membrane associated tyrosine/threonine 1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; membrane associated tyrosine and threonine specific cdc2 inhibitory kinase; MYT1; myt1 kinase; FLJ20093; DKFZp5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
PKMYT1 involved in several pathways and played different roles in them. We selected most pathways PKMYT1 participated on our site, such as Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKMYT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | MCM8;PCM1;APITD1;CDKN2C;NDEL1B;RAD21;CNEP1R1;CENPN;WEE2 |
| Oocyte meiosis | IGF1RA;RPS6KA2;CPEB3;FBXW11A;SPDYA;Ar;PRKACG;PPP1CC;PLCZ1 |
| Progesterone-mediated oocyte maturation | INS2;INSB;CCNB2;MAD2L1;GNAIA;GNAI2;RPS6KA1;MAPK8A;HSP90AA1.2 |
PKMYT1 has several biochemical functions, for example, ATP binding, kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKMYT1 itself. We selected most functions PKMYT1 had, and list some proteins which have the same functions with PKMYT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ENTPD2;P2RX4;STK10;EPHB3;MAK;PRKG1A;ACSL3;KIF19;ABCF2A |
| kinase activity | PKDCCA;NEK5;CDK5R1A;CCL3;CCNE1;CAMK1DB;CAMK2N1A;MAPKAPK2B;JAK2A |
| metal ion binding | RAB11FIP4;REST;TCN2;ZNF217;BHLHE22;ZNF613;RNF216;ZNF777;ATP9A |
| protein binding | MEIS1B;CAND2;KLRG1;KCNE1;EAF2;SLC7A11;LEF1;SMAD2;SIX4 |
| protein kinase activity | CAMK2G1;NEK5;PIK3C3;PRKACBB;NPR2;SOX9;MAP4K6;RPS6KA3;TAOK1 |
| protein serine/threonine kinase activity | CDK1;MAPK6;CLK1;PIM3;SNRKA;ULK4;PRPF4B;TGFBR1;ACVR2B |
PKMYT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKMYT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKMYT1.
CCNB1; CDK1; Cdk1; PPP1CA; N/A; PLK1; linkable pd173955 analogue; bosutinib; imatinib; dasatinib; TGOLN2
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, the expression levels of PKMYT1 can be indicative of the responsiveness of cancer cells to specific treatments, making it a potential predictive biomarker.
Yes, several clinical trials are investigating the efficacy of PKMYT1 inhibitors in various cancer types.
Selective PKMYT1 inhibitors aim to minimize effects on normal cells, but potential impacts on the cell cycle of non-cancerous cells are still under investigation.
Yes, understanding the individual expression levels of PKMYT1 in a patient's tumor can contribute to personalized treatment plans.
PKMYT1 regulates the cell cycle by inhibiting the activity of cyclin-dependent kinases (CDKs), particularly CDK1, which is crucial for G2/M phase transition.
Customer Reviews (3)
Write a reviewManufacturers often have a wealth of knowledge and expertise in the field of PKMYT1 protein research.
The manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of PKMYT1 protein in trials.
They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of PKMYT1 protein in their studies.
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