PLD2
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Official Full Name
phospholipase D2 -
Overview
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PLD2;phospholipase D2;choline phosphatase 2;EC 3.1.4.4;hPLD 2;hPLD2;mPLD2;Phosphatidylcholine hydrolyzing phospholipase D2;Phosphatidylcholine-hydrolyzing phospholipase D2;PhospholipaseD2;PLD 2;PLD1C;Pldc;rPLD2;OTTHUMP00000115984
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- Yeast
- Baculovirus
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
PLD2 involved in several pathways and played different roles in them. We selected most pathways PLD2 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | PIK3R5,PPAP2A,PDGFA,SP1,PDGFRA,PIK3CD,KRAS,DGKE,PIP5K1A,PPAP2C |
| Ether lipid metabolism | PPAP2CB,PLA2G2D,ENPP6,GAL3ST1,PAFAH1B1A,PLA2G12A,PLA2G4C,PAFAH1B1B,PLB1,PPAP2A |
| GnRH signaling pathway | GRB2A,MAPK14A,CALM1A,CAMK2G1,PRKCD,GNRH1,CACNA1SB,GNRHR,MAPK13,MAPK12A |
| Sphingolipid signaling pathway | LASS5,PIK3CG,CERS5,SGPP2,PRKCB,PPP2R2D,RAC2,S1PR2,NRAS,SPTLC1 |
| Ras signaling pathway | PIK3R2,RRAS,PLA2G4A,KIT,PIK3R1,TEK,SHC2,KLK1B4,RAC1,ANGPT1 |
| Metabolic pathways | CYP2P9,AMD1,ATP6V1C1B,ANPEP,CKMT1B,UGT8,PTGS2,SPR,POLR3D,IDO1 |
| Endocytosis | WIPF1A,CHMP5B,ARF6A,EHD1A,RAB5C,SMAP2,TGFBR1,PARD6GB,ARRB1,EHD4 |
| Fc gamma R-mediated phagocytosis | VASP,DOCK2,SPHK1,PIP5K1A,ASAP3,PLA2G4F,HCK,PPAP2B,PIK3R2,MYO10 |
| cAMP signaling pathway | RHOA,NFKBIA,NFATC1,ROCK1,ATP2B4,PDE4B,GNAS,GRIN2C,VIPR2,GRIN3A |
Protein Function
PLD2 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity,phosphatidylinositol binding,phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD2 itself. We selected most functions PLD2 had, and list some proteins which have the same functions with PLD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BEND3,MIER1,CXADR,GTPBP4,TDRD7,HSFX1,RBCK1,SERPINA1,DDI1,CC10 |
| phosphatidylinositol binding | TULP4A,SNX16,SNX5,ESYT2,SNX9B,SNX9,SNX1B,SNX27A,SNX9A,SNX18A |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | PLD1,NAPEPLD,PLD4,PLD3 |
| phospholipase D activity | PLD1A,PLD3,PLD4,PLD1,GPLD1,HMOX1 |
Interacting Protein
PLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD2.
grb2_cerae_protein;GRB2;sos_chlae_protein;CFL1;ptpn1_cerae_protein;FTSJ1;CFTR
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References
- Voss, KE; Bollag, RJ; et al. Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders. ARCHIVES OF DERMATOLOGICAL RESEARCH 303:591-600(2011).
- Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).
