PLSCR1
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Official Full Name
Phospholipid Scramblase 1
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Overview
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. -
Synonyms
Ca(2+)-dependent phospholipid scramblase 1; PL scramblase 1; MMTRA1B; PLSCR1; Erythrocyte phospholipid scramblase; phospholipid scramblase 1; OTTHUMP00000215253; OTTHUMP00000215254; OTTHUMP00000215255; OTTHUMP00000215311; OTTHUMP00000215316;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PLSCR1 involved in several pathways and played different roles in them. We selected most pathways PLSCR1 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLSCR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | ZFP259;RALBP1;RGS16;RBB4L;WNK1;ARF4;KRT17;SH2D3C;KRT8 |
PLSCR1 has several biochemical functions, for example, CD4 receptor binding, DNA binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLSCR1 itself. We selected most functions PLSCR1 had, and list some proteins which have the same functions with PLSCR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CD4 receptor binding | LCK;SPG21;PLSCR4;PLSCR1;FYN |
| DNA binding | ZNF358;HOXB1B;UNCX;NKX2-1;GON4L;ZNF131;ONECUT1;ZNF2;SMARCC1 |
| SH3 domain binding | PTTG2;SH3BP5B;GRIK5;REPS1;MICAL1;ILK;DNM2;GPX1;ARHGAP17 |
| calcium ion binding | PLCH2;JAG1;MASP2;PLCB4;OC90;NCS1B;CPS1;DSG2.1;DOC2D |
| enzyme binding | APBA3;DAOA;LYN;LGALS9;CYP2E1;CABYR;HYAL2;NLRP1;ADORA2A |
| epidermal growth factor receptor binding | BTC;EGF;VAV3;HBEGFA;FAM83B;FER;HBEGF;SOCS5;GRB2 |
| phospholipid scramblase activity | PLSCR2;ANO7;ANO6;PLSCR3A;PLSCR3B;PLSCR4;PLSCR1;PLSCR3;ANO9 |
| protein binding | TP53INP1;CDA;LSM11;RECQL4;SUSD2;SNTB1;WAPAL;SULT1A1;MAGEB2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MYBL1;POU3F2;PAX8;ZSCAN21;OTX2;DDIT3;MYB;STK16;GRHL1 |
PLSCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLSCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLSCR1.
GLRX3; EWSR1; DAZAP2; ILF3; polg_hcvco
Research Area
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