PNMT
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Official Full Name
phenylethanolamine N-methyltransferase -
Overview
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] -
Synonyms
PNMT;phenylethanolamine N-methyltransferase;PENT;PNMTase;phenylethanolamine N-methylase;noradrenaline N-methyltransferase
Recombinant Proteins
- Human
- Mouse
- Rat
- Insect Cells
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PNMT involved in several pathways and played different roles in them. We selected most pathways PNMT participated on our site, such as Tyrosine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | B3GNT2B,COX6C,PIGS,SMPD2A,ODC1,CYP3A7-CYP3AP1,TPH1B,TGDS,INPP5B,GANC |
| Tyrosine metabolism | ADH2-2,DBH,TAT,AOC3,ALDH1A3,AOX2P,ALDH3B1,GOT2B,IL4I1,ADH1 |
Protein Function
PNMT has several biochemical functions, for example, phenylethanolamine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNMT itself. We selected most functions PNMT had, and list some proteins which have the same functions with PNMT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PNMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNMT here. Most of them are supplied by our site. Hope this information will be useful for your research of PNMT.
TERF1;TERF2IP
Resources
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References
- Wu, XM; Hu, CP; et al. Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla. PLOS ONE 6:-(2011).
- Hettie, KS; Liu, X; et al. Selective Catecholamine Recognition with NeuroSensor 521: A Fluorescent Sensor for the Visualization of Norepinephrine in Fixed and Live Cells. ACS CHEMICAL NEUROSCIENCE 4:918-923(2013).
